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PPIG peptidylprolyl isomerase G [ Homo sapiens (human) ]

Gene ID: 9360, updated on 3-Apr-2024

Summary

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Official Symbol
PPIGprovided by HGNC
Official Full Name
peptidylprolyl isomerase Gprovided by HGNC
Primary source
HGNC:HGNC:14650
See related
Ensembl:ENSG00000138398 MIM:606093; AllianceGenome:HGNC:14650
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CYP; SRCyp; SCAF10; CARS-Cyp
Summary
Enables cyclosporin A binding activity and peptidyl-prolyl cis-trans isomerase activity. Involved in protein peptidyl-prolyl isomerization. Located in cytosol and nuclear speck. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thyroid (RPKM 12.9), endometrium (RPKM 11.6) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
2q31.1
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (169584351..169641406)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (170060945..170118571)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (170440861..170497916)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene kelch like family member 41 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:170393950-170394098 Neighboring gene FAST kinase domains 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:170429982-170430584 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16741 Neighboring gene MPRA-validated peak3919 silencer Neighboring gene CYFIP related Rac1 interactor B pseudogene Neighboring gene cilia and flagella associated protein 210 Neighboring gene PHOSPHO2-KLHL23 readthrough Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16742 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12082 Neighboring gene phosphatase, orphan 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Over-expression of SR-cyclophilin, an interaction partner of nuclear pinin, releases SR family splicing factors from nuclear speckles. Lin CL, et al. Biochem Biophys Res Commun, 2004 Aug 27. PMID 15358154
  2. RS cyclophilins: identification of an NK-TR1-related cyclophilin. Nestel FP, et al. Gene, 1996 Nov 21. PMID 8973360
  3. Splicing factors differentially expressed in psoriasis alter mRNA maturation of disease-associated EDA+ fibronectin. Szlavicz E, et al. Mol Cell Biochem, 2017 Dec. PMID 28589370
  4. Zebularine upregulates expression of CYP genes through inhibition of DNMT1 and PKR in HepG2 cells. Nakamura K, et al. Sci Rep, 2017 Jan 23. PMID 28112215, Free PMC Article
  5. The human nuclear SRcyp is a cell cycle-regulated cyclophilin. Dubourg B, et al. J Biol Chem, 2004 May 21. PMID 15016823

See all (72) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The finding that zebularine upregulates CYP gene expression through DNMT1 and PKR modulation sheds light on the mechanisms controlling hepatocyte function and thus may aid in the development of new in-vitro systems using high-functioning hepatocytes
    Title: Zebularine upregulates expression of CYP genes through inhibition of DNMT1 and PKR in HepG2 cells.
  2. results indicate that LUC7L3, PPIG, and SFRS18 are not only implicated in EDA+ fibronectin formation, but also that they could possess multiple roles in psoriasis-associated molecular abnormalities.
    Title: Splicing factors differentially expressed in psoriasis alter mRNA maturation of disease-associated EDA+ fibronectin.
  3. Observational study of gene-disease association. (HuGE Navigator)
    Title: A common variant in DRD3 receptor is associated with autism spectrum disorder.
  4. Results show that SR-cyclophilin interacts and colocalizes with nuclear pinin, a SR-related protein involved in pre-mRNA splicing.
    Title: Over-expression of SR-cyclophilin, an interaction partner of nuclear pinin, releases SR family splicing factors from nuclear speckles.
  5. human nuclear SRcyp is a cell cycle-regulated cyclophilin
    Title: The human nuclear SRcyp is a cell cycle-regulated cyclophilin.
Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Tat tat Expression of HIV-1 Tat downregulates the abundance of peptidylprolyl isomerase G (PPIG, cyclophilin G) in the nucleoli of Jurkat T-cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC133241

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables cyclosporin A binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cyclosporin A binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables peptidyl-prolyl cis-trans isomerase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables peptidyl-prolyl cis-trans isomerase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in RNA splicing TAS
Traceable Author Statement
more info
 PubMed 
involved_in protein folding IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein peptidyl-prolyl isomerization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein peptidyl-prolyl isomerization IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nuclear matrix IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear speck IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
peptidyl-prolyl cis-trans isomerase G
Names
CARS-cyclophilin
CASP10
Clk-associating RS-cyclophilin
PPIase G
SR-cyclophilin
SR-cyp
SR-related CTD-associated factor 10
cyclophilin G
peptidyl-prolyl isomerase G (cyclophilin G)
rotamase G
NP_004783.2
XP_005247023.1
XP_005247024.1
XP_016860791.1
XP_054200604.1
XP_054200605.1
XP_054200606.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_004792.3 → NP_004783.2  peptidyl-prolyl cis-trans isomerase G

    See identical proteins and their annotated locations for NP_004783.2

    Status: VALIDATED

    Source sequence(s)
    AC016772, BG615922, CA418130, X99717
    Consensus CDS
    CCDS2235.1
    UniProtKB/Swiss-Prot
    D3DPC5, D3DPC6, O00706, Q13427, Q53R40, Q53SN4, Q96DG9
    UniProtKB/TrEMBL
    A0A7I2V5Q5
    Related
    ENSP00000260970.3, ENST00000260970.8
    Conserved Domains (2) summary
    PTZ00121
    Location:392 → 752
    PTZ00121; MAEBL; Provisional
    cl00197
    Location:8 → 175
    cyclophilin; cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the immunosuppressive drug ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    169584351..169641406
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005246967.2 → XP_005247024.1  peptidyl-prolyl cis-trans isomerase G isoform X1

    See identical proteins and their annotated locations for XP_005247024.1

    UniProtKB/Swiss-Prot
    D3DPC5, D3DPC6, O00706, Q13427, Q53R40, Q53SN4, Q96DG9
    UniProtKB/TrEMBL
    A0A7I2V5Q5
    Related
    ENSP00000503525.1, ENST00000676756.1
    Conserved Domains (2) summary
    PTZ00121
    Location:392 → 752
    PTZ00121; MAEBL; Provisional
    cl00197
    Location:8 → 175
    cyclophilin; cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the immunosuppressive drug ...

  2. XM_017005302.3 → XP_016860791.1  peptidyl-prolyl cis-trans isomerase G isoform X2

  3. XM_005246966.3 → XP_005247023.1  peptidyl-prolyl cis-trans isomerase G isoform X1

    See identical proteins and their annotated locations for XP_005247023.1

    UniProtKB/Swiss-Prot
    D3DPC5, D3DPC6, O00706, Q13427, Q53R40, Q53SN4, Q96DG9
    UniProtKB/TrEMBL
    A0A7I2V5Q5
    Related
    ENSP00000503136.1, ENST00000678499.1
    Conserved Domains (2) summary
    PTZ00121
    Location:392 → 752
    PTZ00121; MAEBL; Provisional
    cl00197
    Location:8 → 175
    cyclophilin; cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the immunosuppressive drug ...

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    170060945..170118571
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054344630.1 → XP_054200605.1  peptidyl-prolyl cis-trans isomerase G isoform X1

  2. XM_054344631.1 → XP_054200606.1  peptidyl-prolyl cis-trans isomerase G isoform X2

  3. XM_054344629.1 → XP_054200604.1  peptidyl-prolyl cis-trans isomerase G isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q13427.2 GenPept UniProtKB/Swiss-Prot:Q13427

Gene LinkOut

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