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CD163 CD163 molecule [ Homo sapiens (human) ]

Gene ID: 9332, updated on 23-Apr-2024

Summary

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Official Symbol
CD163provided by HGNC
Official Full Name
CD163 moleculeprovided by HGNC
Primary source
HGNC:HGNC:1631
See related
Ensembl:ENSG00000177575 MIM:605545; AllianceGenome:HGNC:1631
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
M130; MM130; SCARI1
Summary
The protein encoded by this gene is a member of the scavenger receptor cysteine-rich (SRCR) superfamily, and is exclusively expressed in monocytes and macrophages. It functions as an acute phase-regulated receptor involved in the clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages, and may thereby protect tissues from free hemoglobin-mediated oxidative damage. This protein may also function as an innate immune sensor for bacteria and inducer of local inflammation. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]
Expression
Broad expression in appendix (RPKM 85.9), spleen (RPKM 66.5) and 18 other tissues See more
Orthologs
all
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Genomic context

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Location:
12p13.31
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (7470811..7503777, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (7484506..7517489, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (7623407..7656373, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene CD163 molecule like 1 Neighboring gene uncharacterized LOC101927882 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr12:7521391-7522590 Neighboring gene M-phase phosphoprotein 8 pseudogene Neighboring gene uncharacterized LOC124902870 Neighboring gene NANOG hESC enhancer GRCh37_chr12:7650144-7650645 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_30893 Neighboring gene MPRA-validated peak1556 silencer Neighboring gene glyceraldehyde 3 phosphate dehydrogenase pseudogene 31 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr12:7736568-7737767 Neighboring gene Sharpr-MPRA regulatory region 13430 Neighboring gene NIFK pseudogene 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Soluble CD163 is a predictor of fibrosis and hepatocellular carcinoma development in nonalcoholic steatohepatitis. Kawanaka M, et al. BMC Gastroenterol, 2023 May 10. PMID 37165352, Free PMC Article
  2. The clinical utility of CD163 in viral diseases. Yap YJ, et al. Clin Chim Acta, 2023 Feb 15. PMID 36740088
  3. Higher Soluble CD163 in Blood Is Associated With Significant Depression Symptoms in Men With HIV. Anderson AM, et al. J Acquir Immune Defic Syndr, 2022 Nov 1. PMID 35969468, Free PMC Article
  4. Urinary CD163 is a marker of active kidney disease in childhood-onset lupus nephritis. Inthavong H, et al. Rheumatology (Oxford), 2023 Mar 1. PMID 35961024, Free PMC Article
  5. Interstitial lung disease progression in patients with anti-aminoacyl transfer-RNA-synthetase autoantibodies is characterized by higher levels of sCD163. Ramos-Martínez E, et al. Immunol Lett, 2022 Aug. PMID 35728747

See all (303) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CD163 as a Potential Biomarker-associated Immune Inflammation in Diabetes Mellitus: A Systematic Review and Bioinformatics Analysis.
    Title: CD163 as a Potential Biomarker-associated Immune Inflammation in Diabetes Mellitus: A Systematic Review and Bioinformatics Analysis.
  2. Differential expression of Semaphorin-7A /CD163-positive macrophages in large artery and cardiogenic stroke.
    Title: Differential expression of Semaphorin-7A /CD163-positive macrophages in large artery and cardiogenic stroke.
  3. The relationship between high ratios of CD4/FOXP3 and CD8/CD163 and the improved survivability of metastatic triple-negative breast cancer patients: a multicenter cohort study.
    Title: The relationship between high ratios of CD4/FOXP3 and CD8/CD163 and the improved survivability of metastatic triple-negative breast cancer patients: a multicenter cohort study.
  4. Clinical Utility of Soluble CD163 and its Diagnostic and Prognostic Value in a Variety of Neurological Disorders.
    Title: Clinical Utility of Soluble CD163 and its Diagnostic and Prognostic Value in a Variety of Neurological Disorders.
  5. Circulating soluble CD163 as a potential biomarker of diabetes complications.
    Title: Circulating soluble CD163 as a potential biomarker of diabetes complications.
  6. Prognostic role of the innate immune signature CD163 and "eat me" signal calreticulin in clear cell renal cell carcinoma.
    Title: Prognostic role of the innate immune signature CD163 and "eat me" signal calreticulin in clear cell renal cell carcinoma.
  7. Soluble CD163 is a predictor of fibrosis and hepatocellular carcinoma development in nonalcoholic steatohepatitis.
    Title: Soluble CD163 is a predictor of fibrosis and hepatocellular carcinoma development in nonalcoholic steatohepatitis.
  8. The clinical utility of CD163 in viral diseases.
    Title: The clinical utility of CD163 in viral diseases.
  9. Urinary CD163 is a marker of active kidney disease in childhood-onset lupus nephritis.
    Title: Urinary CD163 is a marker of active kidney disease in childhood-onset lupus nephritis.
  10. Bone marrow expression of CD68/CD163 macrophages, IL-17 and FOXP3 cells in aplastic anemia and their relation to prognosis.
    Title: Bone marrow expression of CD68/CD163 macrophages, IL-17 and FOXP3 cells in aplastic anemia and their relation to prognosis.
Submit: New GeneRIF Correction See all GeneRIFs (262)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study of hematological and biochemical traits in a Japanese population.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Replication interactions

Interaction Pubs
HIV-1 infected patient clinical samples exhibit an upregulation of CXCL10 and soluble CD163, which correlates with viral load PubMed
Knockdown of CD163 molecule by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Nef nef HIV-1 Nef downregulates CD163 expression in M2-type macrophages PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables scaffold protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables scavenger receptor activity NAS
Non-traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in acute-phase response IEA
Inferred from Electronic Annotation
more info
  
involved_in vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in endocytic vesicle membrane TAS
Traceable Author Statement
more info
  
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in external side of plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular region TAS
Traceable Author Statement
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
scavenger receptor cysteine-rich type 1 protein M130
Names
hemoglobin scavenger receptor
macrophage-associated antigen

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029826.1 RefSeqGene

    Range
    5042..38008
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001370145.1 → NP_001357074.1  scavenger receptor cysteine-rich type 1 protein M130 isoform b precursor

    Status: REVIEWED

    Source sequence(s)
    AC131206
    Consensus CDS
    CCDS53742.1
    UniProtKB/TrEMBL
    F5GZZ9
    Conserved Domains (1) summary
    smart00202
    Location:719 → 819
    SR; Scavenger receptor Cys-rich

  2. NM_001370146.1 → NP_001357075.1  scavenger receptor cysteine-rich type 1 protein M130 isoform c precursor

    Status: REVIEWED

    Source sequence(s)
    AC131206
    UniProtKB/TrEMBL
    F5GZZ9
    Conserved Domains (1) summary
    smart00202
    Location:719 → 819
    SR; Scavenger receptor Cys-rich

  3. NM_004244.6 → NP_004235.4  scavenger receptor cysteine-rich type 1 protein M130 isoform a precursor

    See identical proteins and their annotated locations for NP_004235.4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1), also known as long tail variant 1, represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AC131206, AI129762, BC051281, DA619387, DB291765
    Consensus CDS
    CCDS8578.1
    UniProtKB/Swiss-Prot
    C9JIG2, Q07898, Q07899, Q07900, Q07901, Q2VLH7, Q86VB7
    UniProtKB/TrEMBL
    F5GZZ9
    Related
    ENSP00000352071.4, ENST00000359156.8
    Conserved Domains (2) summary
    smart00202
    Location:719 → 819
    SR; Scavenger receptor Cys-rich
    pfam00530
    Location:724 → 819
    SRCR; Scavenger receptor cysteine-rich domain

  4. NM_203416.4 → NP_981961.2  scavenger receptor cysteine-rich type 1 protein M130 isoform b precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2), also known as short tail variant, uses an alternate splice site in the 3' coding region compared to variant 1. This results in a novel 3' coding region and 3' UTR, compared to variant 1. It encodes isoform b which is shorter, and has a distinct C-terminus, compared to isoform a.
    Source sequence(s)
    AC131206, AI129762, BC051281, DA619387, DB291765, DQ058615
    Consensus CDS
    CCDS53742.1
    UniProtKB/TrEMBL
    F5GZZ9
    Related
    ENSP00000403885.2, ENST00000432237.3
    Conserved Domains (1) summary
    smart00202
    Location:719 → 819
    SR; Scavenger receptor Cys-rich

RNA

  1. NR_163255.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC131206

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    7470811..7503777 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024449278.2 → XP_024305046.1  scavenger receptor cysteine-rich type 1 protein M130 isoform X2

    UniProtKB/TrEMBL
    C9JHR8, F5GZZ9
    Related
    ENSP00000379863.3, ENST00000396620.7
    Conserved Domains (1) summary
    smart00202
    Location:752 → 852
    SR; Scavenger receptor Cys-rich

  2. XM_047429895.1 → XP_047285851.1  scavenger receptor cysteine-rich type 1 protein M130 isoform X1

    Related
    ENST00000537044.1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    7484506..7517489 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054373862.1 → XP_054229837.1  scavenger receptor cysteine-rich type 1 protein M130 isoform X2

  2. XM_054373861.1 → XP_054229836.1  scavenger receptor cysteine-rich type 1 protein M130 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q86VB7.2 GenPept UniProtKB/Swiss-Prot:Q86VB7

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