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CD8B2 CD8B family member 2 [ Homo sapiens (human) ]

Gene ID: 927, updated on 17-Sep-2024

Summary

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Official Symbol
CD8B2provided by HGNC
Official Full Name
CD8B family member 2provided by HGNC
Primary source
HGNC:HGNC:1708
See related
Ensembl:ENSG00000254126 AllianceGenome:HGNC:1708
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CD8BP
Summary
Predicted to enable MHC class I protein binding activity and coreceptor activity. Predicted to be involved in adaptive immune response and regulation of immune response. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Predicted to be active in cell surface. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See CD8B2 in Genome Data Viewer
Location:
2q12.2
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (106487364..106544297)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (106948808..107005766)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (107103820..107160753)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene plasminogen like A (pseudogene) Neighboring gene RANBP2 like and GRIP domain containing 3 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:107056244-107056460 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:107060799-107061300 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:107084140-107084332 Neighboring gene anaphase-promoting complex subunit 1-like Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:107118971-107119470 Neighboring gene uncharacterized LOC124907863 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:107206419-107206639 Neighboring gene eukaryotic translation elongation factor 1 alpha 1 pseudogene 12

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Chromosomal mapping of the second human CD8B gene locus. Zhang XL, et al. Immunogenetics, 1996. PMID 8575821
  2. Duplication of the CD8 beta-chain gene as a marker of the man-gorilla-chimpanzee clade. Delarbre C, et al. Proc Natl Acad Sci U S A, 1993 Aug 1. PMID 8346216, Free PMC Article
  3. Transcriptional diversity at the duplicated human CD8 beta loci. DiSanto JP, et al. Eur J Immunol, 1993 Feb. PMID 8436166
  4. Recent duplication of the two human CD8 beta-chain genes. Nakayama K, et al. J Immunol, 1992 Mar 15. PMID 1541829
  5. Sequence and evolution of the human T-cell antigen receptor beta-chain genes. Tunnacliffe A, et al. Proc Natl Acad Sci U S A, 1985 Aug. PMID 3860845, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables MHC class I protein binding IEA
Inferred from Electronic Annotation
more info
  
enables coreceptor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in adaptive immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of immune response IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cell surface IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
T-cell surface glycoprotein CD8 beta-2 chain
Names
CD8 antigen, beta polypeptide pseudogene
CD8b molecule pseudogene
CD8b pseudogene
CD8b2 molecule
putative T-cell surface glycoprotein CD8 beta-2 chain

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001349727.2 → NP_001336656.1  T-cell surface glycoprotein CD8 beta-2 chain isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AC108868, CA867855, HY085838
    Consensus CDS
    CCDS86870.1
    UniProtKB/Swiss-Prot
    A0A2R8Y7N9, A6NJW9
    UniProtKB/TrEMBL
    E9PD41
    Related
    ENSP00000496416.1, ENST00000643224.2
    Conserved Domains (1) summary
    cd07700
    Location:29 → 134
    IgV_CD8_beta; Immunoglobulin (Ig) like domain of CD8 beta chain

  2. NM_001368307.2 → NP_001355236.1  T-cell surface glycoprotein CD8 beta-2 chain isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC108868
    Consensus CDS
    CCDS92827.1
    UniProtKB/TrEMBL
    A0A2R8Y6U7, B4E0F8, E7EPH5
    Related
    ENSP00000495575.1, ENST00000416057.2
    Conserved Domains (1) summary
    cd07700
    Location:29 → 134
    IgV_CD8_beta; Immunoglobulin (Ig) like domain of CD8 beta chain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    106487364..106544297
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024453217.2 → XP_024308985.1  T-cell surface glycoprotein CD8 beta-2 chain isoform X1

    UniProtKB/TrEMBL
    B4E0F8, E7EPH5, E9PD41
    Conserved Domains (1) summary
    cd07700
    Location:29 → 134
    IgV_CD8_beta; Immunoglobulin (Ig) like domain of CD8 beta chain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    106948808..107005766
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NG_002423.4: Suppressed sequence

    Description
    NG_002423.4: This RefSeq was removed because it is now thought this locus is transcribed.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A6NJW9.3 GenPept UniProtKB/Swiss-Prot:A6NJW9

Gene LinkOut

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Chemical Information
Molecular Biology Databases
Research Materials