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ZNF461 zinc finger protein 461 [ Homo sapiens (human) ]

Gene ID: 92283, updated on 5-Mar-2024

Summary

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Official Symbol
ZNF461provided by HGNC
Official Full Name
zinc finger protein 461provided by HGNC
Primary source
HGNC:HGNC:21629
See related
Ensembl:ENSG00000197808 MIM:608640; AllianceGenome:HGNC:21629
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GIOT1; HZF28; GIOT-1
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis (RPKM 1.8), thyroid (RPKM 1.6) and 25 other tissues See more
Orthologs
all
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Genomic context

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See ZNF461 in Genome Data Viewer
Location:
19q13.12
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (36636618..36666837, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (39311920..39342122, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (37127520..37157739, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 529 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14527 Neighboring gene ZNF529 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14528 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10549 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14529 Neighboring gene zinc finger protein 382 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14530 Neighboring gene zinc finger protein 567 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14531 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10550 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:37178931-37179570 Neighboring gene ZNF567 divergent transcript Neighboring gene zinc finger protein 850 Neighboring gene Sharpr-MPRA regulatory region 9870 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14532

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Characterization of two novel KRAB-domain-containing zinc finger genes, ZNF460 and ZNF461, on human chromosome 19q13.1-->q13.4. Dai J, et al. Cytogenet Genome Res, 2003. PMID 15004467
  2. Cloning and characterization of gonadotropin-inducible ovarian transcription factors (GIOT1 and -2) that are novel members of the (Cys)(2)-(His)(2)-type zinc finger protein family. Mizutani T, et al. Mol Endocrinol, 2001 Oct. PMID 11579202
  3. Cloning and characterization of granulosa cell high-mobility group (HMG)-box protein-1, a novel HMG-box transcriptional regulator strongly expressed in rat ovarian granulosa cells. Kajitani T, et al. Endocrinology, 2004 May. PMID 14764631
  4. Isolation of cDNA clones for 42 different Krüppel-related zinc finger proteins expressed in the human monoblast cell line U-937. Abrink M, et al. DNA Cell Biol, 1995 Feb. PMID 7865130
  5. Estrogen-regulated feedback loop limits the efficacy of estrogen receptor-targeted breast cancer therapy. Xiao T, et al. Proc Natl Acad Sci U S A, 2018 Jul 31. PMID 29987050, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Molecular cloning and tissue distribution of ZNF461.
    Title: Characterization of two novel KRAB-domain-containing zinc finger genes, ZNF460 and ZNF461, on human chromosome 19q13.1-->q13.4.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC33911

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 461
Names
gonadotropin-inducible ovary transcription repressor 1
zinc finger protein 28

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001297623.3 → NP_001284552.1  zinc finger protein 461 isoform 2

    See identical proteins and their annotated locations for NP_001284552.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. It encodes isoform 2, which lacks an internal segment and is shorter, compared to isoform 1.
    Source sequence(s)
    AB021641, AC074138, AK299370
    Consensus CDS
    CCDS74348.1
    UniProtKB/TrEMBL
    B4DRP8
    Related
    ENSP00000353515.4, ENST00000360357.8
    Conserved Domains (4) summary
    smart00349
    Location:6 → 66
    KRAB; krueppel associated box
    COG5048
    Location:289 → 492
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:420 → 440
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:264 → 289
    zf-H2C2_2; Zinc-finger double domain

  2. NM_001322821.2 → NP_001309750.1  zinc finger protein 461 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC074138
    Conserved Domains (5) summary
    smart00349
    Location:2 → 60
    KRAB; krueppel associated box
    COG5048
    Location:306 → 509
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:437 → 457
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:2 → 39
    KRAB; KRAB box
    pfam13465
    Location:449 → 472
    zf-H2C2_2; Zinc-finger double domain

  3. NM_001322823.2 → NP_001309752.1  zinc finger protein 461 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC074138, BX649031, DC339675
    Conserved Domains (4) summary
    COG5048
    Location:281 → 484
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:412 → 432
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:256 → 281
    zf-H2C2_2; Zinc-finger double domain
    cl02581
    Location:15 → 35
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box

  4. NM_001322825.2 → NP_001309754.1  zinc finger protein 461 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC074138
    Conserved Domains (4) summary
    COG5048
    Location:281 → 484
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:412 → 432
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:256 → 281
    zf-H2C2_2; Zinc-finger double domain
    cl02581
    Location:15 → 35
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box

  5. NM_001322826.2 → NP_001309755.1  zinc finger protein 461 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC074138
    Conserved Domains (4) summary
    COG5048
    Location:258 → 461
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:389 → 409
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:233 → 258
    zf-H2C2_2; Zinc-finger double domain
    cl02581
    Location:15 → 35
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box

  6. NM_001322827.2 → NP_001309756.1  zinc finger protein 461 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC074138
    Conserved Domains (4) summary
    COG5048
    Location:258 → 461
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:389 → 409
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:233 → 258
    zf-H2C2_2; Zinc-finger double domain
    cl02581
    Location:15 → 35
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box

  7. NM_001322828.2 → NP_001309757.1  zinc finger protein 461 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC074138, DC308305, DC339675
    Conserved Domains (3) summary
    COG5048
    Location:224 → 427
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:355 → 375
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:199 → 224
    zf-H2C2_2; Zinc-finger double domain

  8. NM_153257.5 → NP_694989.2  zinc finger protein 461 isoform 1

    See identical proteins and their annotated locations for NP_694989.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AB021641, AC074138, AK299370, AY329493
    Consensus CDS
    CCDS54257.1
    UniProtKB/Swiss-Prot
    A8K9W9, Q6VSF7, Q8TAF7, Q9ULZ8
    Related
    ENSP00000467931.1, ENST00000588268.6
    Conserved Domains (4) summary
    smart00349
    Location:6 → 66
    KRAB; krueppel associated box
    COG5048
    Location:312 → 515
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:443 → 463
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:287 → 312
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    36636618..36666837 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011527486.3 → XP_011525788.1  zinc finger protein 461 isoform X1

    See identical proteins and their annotated locations for XP_011525788.1

    UniProtKB/Swiss-Prot
    Q8TAF7
    Conserved Domains (2) summary
    COG5048
    Location:200 → 388
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:316 → 336
    ZF_C2H2; C2H2 Zn finger [structural motif]

  2. XM_047439680.1 → XP_047295636.1  zinc finger protein 461 isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    39311920..39342122 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054322609.1 → XP_054178584.1  zinc finger protein 461 isoform X1

  2. XM_054322610.1 → XP_054178585.1  zinc finger protein 461 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8TAF7.2 GenPept UniProtKB/Swiss-Prot:Q8TAF7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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