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NOLC1 nucleolar and coiled-body phosphoprotein 1 [ Homo sapiens (human) ]

Gene ID: 9221, updated on 7-Apr-2024

Summary

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Official Symbol
NOLC1provided by HGNC
Official Full Name
nucleolar and coiled-body phosphoprotein 1provided by HGNC
Primary source
HGNC:HGNC:15608
See related
Ensembl:ENSG00000166197 MIM:602394; AllianceGenome:HGNC:15608
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
P130; Srp40; NOPP130; NOPP140; NS5ATP13
Summary
Enables protein heterodimerization activity and protein-macromolecule adaptor activity. Involved in neural crest cell development; neural crest formation; and regulation of translation. Located in fibrillar center. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in brain (RPKM 23.0), thyroid (RPKM 22.8) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
10q24.32
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (102152389..102163870)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (103037369..103048850)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (103912146..103923627)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2738 Neighboring gene HPS6 biogenesis of lysosomal organelles complex 2 subunit 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:103867277-103867778 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr10:103870016-103871215 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2739 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2740 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2741 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2742 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:103876901-103877603 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:103877604-103878305 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2744 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2745 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:103880011-103880762 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:103880763-103881514 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:103881515-103882264 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:103887116-103887946 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3922 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2748 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2749 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2750 Neighboring gene LIM domain binding 1 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr10:103897995-103899194 Neighboring gene PPARG related coactivator 1 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr10:103911632-103912831 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2751 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:103989615-103989783 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2752 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2753 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2754 Neighboring gene ELOVL fatty acid elongase 3 Neighboring gene paired like homeodomain 3 Neighboring gene golgi brefeldin A resistant guanine nucleotide exchange factor 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. NOLC1 knockdown suppresses prostate cancer progressions by reducing AKT phosphorylation and β-catenin accumulation. Kim W, et al. Biochem Biophys Res Commun, 2022 Dec 20. PMID 36265288
  2. Nopp140-mediated concentration of telomerase in Cajal bodies regulates telomere length. Bizarro J, et al. Mol Biol Cell, 2019 Dec 15. PMID 31664887, Free PMC Article
  3. Identification and validation of NOLC1 as a potential target for enhancing sensitivity in multidrug resistant non-small cell lung cancer cells. Huang H, et al. Cell Mol Biol Lett, 2018. PMID 30505321, Free PMC Article
  4. Methylation of nucleolar and coiled-body phosphoprotein 1 is associated with the mechanism of tumorigenesis in hepatocellular carcinoma. Duan X, et al. Oncol Rep, 2013 Nov. PMID 23970161
  5. Structural disorder and local order of hNopp140. Tantos A, et al. Biochim Biophys Acta, 2013 Jan. PMID 22906532

See all (176) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. T7 phage display reveals NOLC1 as a GM3 binding partner in human breast cancer MCF-7 cells.
    Title: T7 phage display reveals NOLC1 as a GM3 binding partner in human breast cancer MCF-7 cells.
  2. High expression of NOLC1 as an independent prognostic factor for survival in patients with colorectal cancer.
    Title: High expression of NOLC1 as an independent prognostic factor for survival in patients with colorectal cancer.
  3. Roles of NOLC1 in cancers and viral infection.
    Title: Roles of NOLC1 in cancers and viral infection.
  4. NOLC1 knockdown suppresses prostate cancer progressions by reducing AKT phosphorylation and beta-catenin accumulation.
    Title: NOLC1 knockdown suppresses prostate cancer progressions by reducing AKT phosphorylation and β-catenin accumulation.
  5. Pten-NOLC1 fusion promotes cancers involving MET and EGFR signalings.
    Title: Pten-NOLC1 fusion promotes cancers involving MET and EGFR signalings.
  6. This study suggests that the dynamic distribution of telomerase between Cajal bodies and nucleoplasm uniquely impacts telomere length maintenance and identifies Nopp140 as a novel player in telomere biology.
    Title: Nopp140-mediated concentration of telomerase in Cajal bodies regulates telomere length.
  7. Nucleolar TRF2 attenuated nucleolus stress-induced hepatocellular carcinoma cell-cycle arrest by altering rRNA synthesis via interaction with NOLC1.
    Title: Nucleolar TRF2 attenuated nucleolus stress-induced HCC cell-cycle arrest by altering rRNA synthesis.
  8. Identification and validation of NOLC1 might be a promising therapeutic strategy for the management of multidrug resistance of non-small cell lung cancer patients.
    Title: Identification and validation of NOLC1 as a potential target for enhancing sensitivity in multidrug resistant non-small cell lung cancer cells.
  9. In this study, the disordered feature of Nopp140 and the effect of CK2alpha on the structure of Nopp140 were examined using single-molecule fluorescence resonance energy transfer (smFRET) and electron paramagnetic resonance (EPR).
    Title: Biophysical characterization of the structural change of Nopp140, an intrinsically disordered protein, in the interaction with CK2α.
  10. D120 and R195 of H5N1 influenza virus NS1 were crucial for the binding to host NOLC1.
    Title: Identification of NS1 domains of avian H5N1 influenza virus which influence the interaction with the NOLC1 protein.
Submit: New GeneRIF Correction See all GeneRIFs (27)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
matrix gag HIV-1 MA is identified to have a physical interaction with nucleolar and coiled-body phosphoprotein 1 (NOLC1) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA0035

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA binding HDA PubMed 
enables molecular function inhibitor activity EXP
Inferred from Experiment
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein heterodimerization activity IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-macromolecule adaptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in mitotic cell cycle TAS
Traceable Author Statement
more info
 PubMed 
involved_in neural crest cell development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in neural crest formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nucleolus organization IEA
Inferred from Electronic Annotation
more info
  
involved_in rRNA processing TAS
Traceable Author Statement
more info
 PubMed 
involved_in regulation of translation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in Cajal body IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in fibrillar center IDA
Inferred from Direct Assay
more info
  
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
nucleolar and coiled-body phosphoprotein 1
Names
140 kDa nucleolar phosphoprotein
HCV NS5A trans-regulated protein 13
HCV NS5A-transactivated protein 13
hepatitis C virus NS5A-transactivated protein 13
nucleolar 130 kDa protein
nucleolar and coiled-body phosphprotein 1
nucleolar phosphoprotein p130
nucleolar protein p130

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001284388.2 → NP_001271317.1  nucleolar and coiled-body phosphoprotein 1 isoform 1

    See identical proteins and their annotated locations for NP_001271317.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AK314363, AL520884, D21262, DA588285
    Consensus CDS
    CCDS65926.1
    UniProtKB/TrEMBL
    A0A0A0MRM9
    Related
    ENSP00000359024.5, ENST00000370007.5
    Conserved Domains (1) summary
    pfam05022
    Location:634 → 700
    SRP40_C; SRP40, C-terminal domain

  2. NM_001284389.2 → NP_001271318.1  nucleolar and coiled-body phosphoprotein 1 isoform 3

    See identical proteins and their annotated locations for NP_001271318.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses two alternate in-frame splice sites in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform 3), compared to isoform 1.
    Source sequence(s)
    AL520884, BC001883, D21262, DA588285
    Consensus CDS
    CCDS65925.1
    UniProtKB/TrEMBL
    B2RAU8
    Related
    ENSP00000475080.1, ENST00000488254.6
    Conserved Domains (1) summary
    pfam05022
    Location:625 → 691
    SRP40_C; SRP40, C-terminal domain

  3. NM_004741.5 → NP_004732.2  nucleolar and coiled-body phosphoprotein 1 isoform 2

    See identical proteins and their annotated locations for NP_004732.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AK314363, AL520884, BC006769
    Consensus CDS
    CCDS7530.1
    UniProtKB/Swiss-Prot
    Q14978, Q15030, Q5VV70, Q9BUV3
    UniProtKB/TrEMBL
    B2RAU8
    Related
    ENSP00000474710.2, ENST00000605788.6
    Conserved Domains (1) summary
    pfam05022
    Location:624 → 690
    SRP40_C; SRP40, C-terminal domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    102152389..102163870
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005270273.3 → XP_005270330.1  nucleolar and coiled-body phosphoprotein 1 isoform X1

    UniProtKB/TrEMBL
    A0A0A0MRM9
    Conserved Domains (1) summary
    pfam05022
    Location:635 → 701
    SRP40_C; SRP40, C-terminal domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    103037369..103048850
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054367144.1 → XP_054223119.1  nucleolar and coiled-body phosphoprotein 1 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q14978.2 GenPept UniProtKB/Swiss-Prot:Q14978

Gene LinkOut

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