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FCMR Fc mu receptor [ Homo sapiens (human) ]

Gene ID: 9214, updated on 3-Apr-2024

Summary

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Official Symbol
FCMRprovided by HGNC
Official Full Name
Fc mu receptorprovided by HGNC
Primary source
HGNC:HGNC:14315
See related
Ensembl:ENSG00000162894 MIM:606015; AllianceGenome:HGNC:14315
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TOSO; FAIM3; FcmuR; IgM FcR
Summary
Fc receptors specifically bind to the Fc region of immunoglobulins (Igs) to mediate the unique functions of each Ig class. FAIM3 encodes an Fc receptor for IgM (see MIM 147020) (Kubagawa et al., 2009 [PubMed 19858324]; Shima et al., 2010 [PubMed 20042454]).[supplied by OMIM, Jul 2010]
Expression
Biased expression in lymph node (RPKM 59.4), spleen (RPKM 52.0) and 6 other tissues See more
Orthologs
mouse all
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Genomic context

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See FCMR in Genome Data Viewer
Location:
1q32.1
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (206903317..206923196, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (206167622..206187486, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (207076662..207095286, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene interleukin 20 Neighboring gene uncharacterized LOC105372879 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:207063449-207064648 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2426 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr1:207078063-207079262 Neighboring gene interleukin 24 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1768 Neighboring gene negCOR silencer S10 Neighboring gene ribosomal protein L13a pseudogene 8 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2427 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2428 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2429 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2430 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2431 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2432 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2433 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2434 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:207103683-207104183 Neighboring gene polymeric immunoglobulin receptor Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1769 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:207134913-207136112 Neighboring gene Fc alpha and mu receptor

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Mapping of the binding site for FcμR in human IgM-Fc. Nyamboya RA, et al. Biochim Biophys Acta Proteins Proteom, 2020 Jan. PMID 31449905, Free PMC Article
  2. Toso, a functional IgM receptor, is regulated by IL-2 in T and NK cells. Murakami Y, et al. J Immunol, 2012 Jul 15. PMID 22675200, Free PMC Article
  3. TOSO, the Fcmicro receptor, is highly expressed on chronic lymphocytic leukemia B cells, internalizes upon IgM binding, shuttles to the lysosome, and is downregulated in response to TLR activation. Vire B, et al. J Immunol, 2011 Oct 15. PMID 21908732, Free PMC Article
  4. Enhanced levels of both the membrane-bound and soluble forms of IgM Fc receptor (FcμR) in patients with chronic lymphocytic leukemia. Li FJ, et al. Blood, 2011 Nov 3. PMID 21908424, Free PMC Article
  5. [Expression and prognostic significance of TOSO in CD19+ B cells from Chinese CLL patients]. Yu Z, et al. Zhonghua Yi Xue Za Zhi, 2011 May 31. PMID 21756805

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Differences between Human and Mouse IgM Fc Receptor (FcmicroR).
    Title: Differences between Human and Mouse IgM Fc Receptor (FcµR).
  2. TOSO interacts with SYK and enhances BCR pathway activation in chronic lymphocytic leukemia.
    Title: TOSO interacts with SYK and enhances BCR pathway activation in chronic lymphocytic leukemia.
  3. TGIF2 promotes cervical cancer metastasis by negatively regulating FCMR.
    Title: TGIF2 promotes cervical cancer metastasis by negatively regulating FCMR.
  4. We conclude that glutamine at position 510 in Cmu4 is critical for IgM binding to FcmuR. This will facilitate discrimination between the distinct effects of FcmuR interactions with soluble IgM and with the IgM BCR.
    Title: Mapping of the binding site for FcμR in human IgM-Fc.
  5. Overexpression of TOSO gene is associated with chronic lymphocytic leukemia.
    Title: Overexpression of Fc mu receptor (FCMR, TOSO) gene in chronic lymphocytic leukemia patients.
  6. Toso/FcmuR is an IgM receptor capable of activating signaling molecules and whose expression alone is not inherently antiapoptotic.
    Title: Toso, a functional IgM receptor, is regulated by IL-2 in T and NK cells.
  7. Overexpression of TOSO in chronic lymphocytic leukemia is associated with disease progression.
    Title: [Expression and prognostic significance of TOSO in CD19+ B cells from Chinese CLL patients].
  8. Enhanced levels of both membrane-bound and soluble forms of FcmuR in CLL patients.
    Title: Enhanced levels of both the membrane-bound and soluble forms of IgM Fc receptor (FcμR) in patients with chronic lymphocytic leukemia.
  9. TOSO/FAIM3 may play a role in immune surveillance and contribute to B cell activation
    Title: TOSO, the Fcmicro receptor, is highly expressed on chronic lymphocytic leukemia B cells, internalizes upon IgM binding, shuttles to the lysosome, and is downregulated in response to TLR activation.
  10. we demonstrate that the immune specific cell surface molecule Toso exhibits antiapoptotic effects on death receptor signaling by a novel regulatory mechanism involving the adaptor kinase RIP1
    Title: Toso regulates the balance between apoptotic and nonapoptotic death receptor signaling by facilitating RIP1 ubiquitination.
Submit: New GeneRIF Correction See all GeneRIFs (19)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables IgM binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables high-affinity IgM receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables polymeric immunoglobulin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transmembrane signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in Fc receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in Fc receptor-mediated immune complex endocytosis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cellular defense response TAS
Traceable Author Statement
more info
 PubMed 
involved_in humoral immune response mediated by circulating immunoglobulin ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in immunoglobulin transcytosis in epithelial cells ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of apoptotic process TAS
Traceable Author Statement
more info
 PubMed 
involved_in regulation of B cell receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in early endosome membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in lysosomal membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in trans-Golgi network membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
immunoglobulin mu Fc receptor; fas apoptotic inhibitory molecule 3
Names
Fas apoptotic inhibitory molecule 3
Fc fragment of IgM receptor
IgM Fc fragment receptor
IgM Fc receptor
regulator of Fas-induced apoptosis Toso

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001142473.2 → NP_001135945.1  immunoglobulin mu Fc receptor isoform b

    See identical proteins and their annotated locations for NP_001135945.1

    Status: VALIDATED

    Source sequence(s)
    AA769146, AI524407, BC006401, BP305798, BP338035, CB158779, DA971987
    Consensus CDS
    CCDS44304.1
    UniProtKB/TrEMBL
    B7Z497
    Related
    ENSP00000404136.2, ENST00000442471.4

  2. NM_001193338.2 → NP_001180267.1  immunoglobulin mu Fc receptor isoform c precursor

    See identical proteins and their annotated locations for NP_001180267.1

    Status: VALIDATED

    Source sequence(s)
    AC098935, AI524407, BC006401, HM480394
    Consensus CDS
    CCDS53467.1
    UniProtKB/Swiss-Prot
    O60667
    Related
    ENSP00000485739.1, ENST00000628511.2
    Conserved Domains (2) summary
    cd05716
    Location:24 → 121
    Ig_pIgR; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR)
    smart00410
    Location:25 → 122
    IG_like; Immunoglobulin like

  3. NM_001405862.1 → NP_001392791.1  immunoglobulin mu Fc receptor isoform d

    Status: VALIDATED

    Source sequence(s)
    AC098935

  4. NM_001405863.1 → NP_001392792.1  immunoglobulin mu Fc receptor isoform d

    Status: VALIDATED

    Source sequence(s)
    AC098935

  5. NM_001405864.1 → NP_001392793.1  immunoglobulin mu Fc receptor isoform e precursor

    Status: VALIDATED

    Source sequence(s)
    AC098935

  6. NM_001405865.1 → NP_001392794.1  immunoglobulin mu Fc receptor isoform e precursor

    Status: VALIDATED

    Source sequence(s)
    AC098935

  7. NM_001405866.1 → NP_001392795.1  immunoglobulin mu Fc receptor isoform f precursor

    Status: VALIDATED

    Source sequence(s)
    AC098935

  8. NM_001405867.1 → NP_001392796.1  immunoglobulin mu Fc receptor isoform g precursor

    Status: VALIDATED

    Source sequence(s)
    AC098935

  9. NM_001405868.1 → NP_001392797.1  immunoglobulin mu Fc receptor isoform g precursor

    Status: VALIDATED

    Source sequence(s)
    AC098935

  10. NM_001405871.1 → NP_001392800.1  immunoglobulin mu Fc receptor isoform a precursor

    Status: VALIDATED

    Source sequence(s)
    AC098935
    UniProtKB/Swiss-Prot
    A8K7J2, B7Z6Z0, D9MWM3, O60667

  11. NM_001405886.1 → NP_001392815.1  immunoglobulin mu Fc receptor isoform h

    Status: VALIDATED

    Source sequence(s)
    AC098935

  12. NM_001405887.1 → NP_001392816.1  immunoglobulin mu Fc receptor isoform b

    Status: VALIDATED

    Source sequence(s)
    AC098935

  13. NM_001405888.1 → NP_001392817.1  immunoglobulin mu Fc receptor isoform j

    Status: VALIDATED

    Source sequence(s)
    AC098935

  14. NM_001405889.1 → NP_001392818.1  immunoglobulin mu Fc receptor isoform k precursor

    Status: VALIDATED

    Source sequence(s)
    AC098935

  15. NM_001405890.1 → NP_001392819.1  immunoglobulin mu Fc receptor isoform l

    Status: VALIDATED

    Source sequence(s)
    AC098935

  16. NM_001405891.1 → NP_001392820.1  immunoglobulin mu Fc receptor isoform m

    Status: VALIDATED

    Source sequence(s)
    AC098935

  17. NM_001405892.1 → NP_001392821.1  immunoglobulin mu Fc receptor isoform n precursor

    Status: VALIDATED

    Source sequence(s)
    AC098935

  18. NM_005449.5 → NP_005440.1  immunoglobulin mu Fc receptor isoform a precursor

    See identical proteins and their annotated locations for NP_005440.1

    Status: VALIDATED

    Source sequence(s)
    AA769146, AI524407, BC006401, BP338035, CB158779
    Consensus CDS
    CCDS1473.1
    UniProtKB/Swiss-Prot
    A8K7J2, B7Z6Z0, D9MWM3, O60667
    Related
    ENSP00000356058.3, ENST00000367091.8
    Conserved Domains (2) summary
    cd05716
    Location:24 → 121
    Ig_pIgR; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR)
    smart00410
    Location:25 → 122
    IG_like; Immunoglobulin like

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    206903317..206923196 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047434331.1 → XP_047290287.1  fas apoptotic inhibitory molecule 3 isoform X1

  2. XM_047434334.1 → XP_047290290.1  fas apoptotic inhibitory molecule 3 isoform X2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    206167622..206187486 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054339614.1 → XP_054195589.1  fas apoptotic inhibitory molecule 3 isoform X1

  2. XM_054339615.1 → XP_054195590.1  fas apoptotic inhibitory molecule 3 isoform X2

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001142472.1: Suppressed sequence

    Description
    NM_001142472.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O60667.1 GenPept UniProtKB/Swiss-Prot:O60667

Gene LinkOut

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