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GP glycoprotein [ Orthomarburgvirus marburgense ]

Gene ID: 920945, updated on 18-Aug-2023

Summary

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Gene symbol
GP
Gene description
glycoprotein
Locus tag
MARV_gp4
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Orthomarburgvirus marburgense (isolate: Marburg virus/H.sapiens-tc/KEN/1980/Mt. Elgon-Musoke)
Lineage
Viruses; Riboviria; Orthornavirae; Negarnaviricota; Haploviricotina; Monjiviricetes; Mononegavirales; Filoviridae; Orthomarburgvirus
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Genomic context

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Sequence:
NC_001608.3 (5825..8670)

NC_001608.3Genomic Context describing neighboring genes Neighboring gene polymerase complex protein Neighboring gene matrix protein Neighboring gene minor nucleoprotein Neighboring gene matrix protein Neighboring gene RNA-dependent RNA polymerase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001608.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Live attenuated recombinant vaccine protects nonhuman primates against Ebola and Marburg viruses. Jones SM, et al. Nat Med, 2005 Jul. PMID 15937495
  2. Carbohydrate structure of Marburg virus glycoprotein. Geyer H, et al. Glycobiology, 1992 Aug. PMID 1421752, Free PMC Article
  3. Glycosylation and oligomerization of the spike protein of Marburg virus. Feldmann H, et al. Virology, 1991 May. PMID 2024471, Free PMC Article
  4. Marburg virus gene 4 encodes the virion membrane protein, a type I transmembrane glycoprotein. Will C, et al. J Virol, 1993 Mar. PMID 8437211, Free PMC Article
  5. Marburg virus vaccines: comparing classical and new approaches. Hevey M, et al. Vaccine, 2001 Nov 12. PMID 11672925

See all (40) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Here the authors show that ectopic expression of Marburg virus GP activated the IRE1-XBP1 axis of unfolded protein response.
    Title: Marburg virus regulates the IRE1/XBP1-dependent unfolded protein response to ensure efficient viral replication.
  2. Study presents the 3.6 A crystal structure of Marburg virus (strain Ravn) GP in complex with a cross-reactive antibody, MR78, from a human survivor, and a lower resolution structure of the antibody bound to Ebola virus(strain Zaire) GP.
    Title: Structural basis for Marburg virus neutralization by a cross-reactive human antibody.
  3. These results suggest that the transmembrane domains of filoviral GPs contribute to tetherin antagonism but are not the sole determinants.
    Title: Analysis of determinants in filovirus glycoproteins required for tetherin antagonism.
  4. These data demonstrate that Marburg virus GP possesses the potential to evade antibody mediated immune pressure due to extraordinary structural flexibility and variability.
    Title: Novel mutations in Marburg virus glycoprotein associated with viral evasion from antibody mediated immune pressure.
  5. These data show that the transmembrane domain of GP is critical for the mixing of VP40 and GP in multivesicular bodies and incorporation of GP into the viral envelope.
    Title: Role of the transmembrane domain of marburg virus surface protein GP in assembly of the viral envelope.
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General gene information

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Homology

General protein information

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Preferred Names
glycoprotein
YP_001531156.1
  • fusion; receptor binding

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001608.3 Reference assembly

    Range
    5825..8670
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. YP_001531156.1 glycoprotein [Orthomarburgvirus marburgense]

    See identical proteins and their annotated locations for YP_001531156.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P35253, Q38L42, Q6T6U0
    UniProtKB/TrEMBL
    G9HWE5
    Conserved Domains (2) summary
    cd09850
    Location:558 → 630
    Ebola-like_HR1-HR2; heptad repeat 1-heptad repeat 2 region of the transmembrane subunit of Filoviridae viruses, Ebola virus and Marburg virus, and related domains
    pfam01611
    Location:1 → 375
    Filo_glycop; Filovirus glycoprotein
Protein Accession Links
GenPept Link UniProtKB Link
ABA87127.1

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