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MYADM myeloid associated differentiation marker [ Homo sapiens (human) ]

Gene ID: 91663, updated on 5-Mar-2024

Summary

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Official Symbol
MYADMprovided by HGNC
Official Full Name
myeloid associated differentiation markerprovided by HGNC
Primary source
HGNC:HGNC:7544
See related
Ensembl:ENSG00000179820 MIM:609959; AllianceGenome:HGNC:7544
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SB135
Summary
Involved in several processes, including negative regulation of heterotypic cell-cell adhesion; negative regulation of macromolecule metabolic process; and negative regulation of protein kinase C signaling. Located in several cellular components, including cortical actin cytoskeleton; membrane raft; and ruffle. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in lung (RPKM 50.4), gall bladder (RPKM 50.0) and 25 other tissues See more
Orthologs
mouse all
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Genomic context

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Location:
19q13.42
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (53865628..53876435)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (56945407..56956143)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (54368882..54379689)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:54295400-54295900 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:54295901-54296401 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:54300296-54300796 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:54301378-54301878 Neighboring gene microRNA 373 Neighboring gene NLR family pyrin domain containing 12 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:54332809-54333578 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:54334349-54335116 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:54335887-54336656 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:54337427-54338194 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr19:54339735-54340504 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:54342811-54343580 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:54343581-54344348 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:54361270-54361770 Neighboring gene MYADM antisense RNA 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:54369942-54370917 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:54372027-54372940 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:54372941-54373854 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:54385903-54386454 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:54395841-54396380 Neighboring gene protein kinase C gamma Neighboring gene Sharpr-MPRA regulatory region 4174 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:54410617-54411158 Neighboring gene calcium voltage-gated channel auxiliary subunit gamma 7 Neighboring gene MPRA-validated peak3551 silencer

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Membrane protein hMYADM preferentially expressed in myeloid cells is up-regulated during differentiation of stem cells and myeloid leukemia cells. Wang Q, et al. Life Sci, 2007 Jan 9. PMID 17097684
  2. Cloning of human myeloid-associated differentiation marker (MYADM) gene whose expression was up-regulated in NB4 cells induced by all-trans retinoic acid. Cui W, et al. Mol Biol Rep, 2001. PMID 12075932
  3. Myeloid-associated differentiation marker is a novel SP-A-associated transmembrane protein whose expression on airway epithelial cells correlates with asthma severity. Dy ABC, et al. Sci Rep, 2021 Dec 3. PMID 34862427, Free PMC Article
  4. miR-182-3p/Myadm contribute to pulmonary artery hypertension vascular remodeling via a KLF4/p21-dependent mechanism. Sun L, et al. Theranostics, 2020. PMID 32373233, Free PMC Article
  5. Isolation of MYADM, a novel hematopoietic-associated marker gene expressed in multipotent progenitor cells and up-regulated during myeloid differentiation. Pettersson M, et al. J Leukoc Biol, 2000 Mar. PMID 10733104

See all (42) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Myeloid-associated differentiation marker is an essential host factor for human parechovirus PeV-A3 entry.
    Title: Myeloid-associated differentiation marker is an essential host factor for human parechovirus PeV-A3 entry.
  2. Myeloid-associated differentiation marker is a novel SP-A-associated transmembrane protein whose expression on airway epithelial cells correlates with asthma severity.
    Title: Myeloid-associated differentiation marker is a novel SP-A-associated transmembrane protein whose expression on airway epithelial cells correlates with asthma severity.
  3. miR-182-3p/Myadm contribute to pulmonary artery hypertension vascular remodeling via a KLF4/p21-dependent mechanism.
    Title: miR-182-3p/Myadm contribute to pulmonary artery hypertension vascular remodeling via a KLF4/p21-dependent mechanism.
  4. MYADM gene expression is significantly associated with long-term changes in Blood Pressure, providing a link between gene expression and Blood Pressure.
    Title: Transcriptome-Wide Analysis Identifies Novel Associations With Blood Pressure.
  5. MYADM controls endothelial barrier function through ERM-dependent regulation of ICAM-1 expression.
    Title: MYADM controls endothelial barrier function through ERM-dependent regulation of ICAM-1 expression.
  6. Myeloid-associated differentiation marker (MYADM) regulates Rac1 targeting to ordered membranes required for cell spreading and migration.
    Title: MYADM regulates Rac1 targeting to ordered membranes required for cell spreading and migration.
  7. Cloning and characterization of human MYADM gene whose expression was up-regulated in NB4 cells induced by all-trans retinoic acid.
    Title: Cloning of human myeloid-associated differentiation marker (MYADM) gene whose expression was up-regulated in NB4 cells induced by all-trans retinoic acid.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • AC008440.10

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
NOT involved_in cell-cell junction maintenance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in establishment of endothelial barrier IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in membrane raft organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of actin filament polymerization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of heterotypic cell-cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of heterotypic cell-cell adhesion IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of protein kinase C signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of substrate adhesion-dependent cell spreading IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein localization to plasma membrane raft IMP
Inferred from Mutant Phenotype
more info
 PubMed 
NOT involved_in regulation of cell-substrate adhesion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cell-cell junction IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cell-cell junction IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cortical actin cytoskeleton IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane raft IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in ruffle IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
myeloid-associated differentiation marker
Names
myeloid upregulated protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001020818.2 → NP_001018654.1  myeloid-associated differentiation marker

    See identical proteins and their annotated locations for NP_001018654.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 6. All twelve variants encode the same protein.
    Source sequence(s)
    AC008440, AF087882, HY124929
    Consensus CDS
    CCDS12866.1
    UniProtKB/Swiss-Prot
    B2RE58, Q542Z1, Q7Z507, Q8N9R4, Q96CS6, Q96S97, Q96SK9
    UniProtKB/TrEMBL
    B4DG42, E9PBN6
    Related
    ENSP00000375648.2, ENST00000391768.2
    Conserved Domains (1) summary
    pfam01284
    Location:168 → 312
    MARVEL; Membrane-associating domain

  2. NM_001020819.3 → NP_001018655.1  myeloid-associated differentiation marker

    See identical proteins and their annotated locations for NP_001018655.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 6. All twelve variants encode the same protein.
    Source sequence(s)
    AC008440, AF087882, DA027466
    Consensus CDS
    CCDS12866.1
    UniProtKB/Swiss-Prot
    B2RE58, Q542Z1, Q7Z507, Q8N9R4, Q96CS6, Q96S97, Q96SK9
    UniProtKB/TrEMBL
    B4DG42, E9PBN6
    Related
    ENSP00000375651.1, ENST00000391771.1
    Conserved Domains (1) summary
    pfam01284
    Location:168 → 312
    MARVEL; Membrane-associating domain

  3. NM_001020820.3 → NP_001018656.1  myeloid-associated differentiation marker

    See identical proteins and their annotated locations for NP_001018656.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 6. All twelve variants encode the same protein.
    Source sequence(s)
    AC008440, AF087882, BX393859, DC379591
    Consensus CDS
    CCDS12866.1
    UniProtKB/Swiss-Prot
    B2RE58, Q542Z1, Q7Z507, Q8N9R4, Q96CS6, Q96S97, Q96SK9
    UniProtKB/TrEMBL
    B4DG42, E9PBN6
    Related
    ENSP00000398269.2, ENST00000421337.6
    Conserved Domains (1) summary
    pfam01284
    Location:168 → 312
    MARVEL; Membrane-associating domain

  4. NM_001020821.2 → NP_001018657.1  myeloid-associated differentiation marker

    See identical proteins and their annotated locations for NP_001018657.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 6. All twelve variants encode the same protein.
    Source sequence(s)
    AC008440, AF087882, HY124929
    Consensus CDS
    CCDS12866.1
    UniProtKB/Swiss-Prot
    B2RE58, Q542Z1, Q7Z507, Q8N9R4, Q96CS6, Q96S97, Q96SK9
    UniProtKB/TrEMBL
    B4DG42, E9PBN6
    Related
    ENSP00000375649.2, ENST00000391769.2
    Conserved Domains (1) summary
    pfam01284
    Location:168 → 312
    MARVEL; Membrane-associating domain

  5. NM_001290188.2 → NP_001277117.1  myeloid-associated differentiation marker

    See identical proteins and their annotated locations for NP_001277117.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR compared to variant 6. All twelve variants encode the same protein.
    Source sequence(s)
    AC008440, AF087882, DC379591
    Consensus CDS
    CCDS12866.1
    UniProtKB/Swiss-Prot
    B2RE58, Q542Z1, Q7Z507, Q8N9R4, Q96CS6, Q96S97, Q96SK9
    UniProtKB/TrEMBL
    B4DG42, E9PBN6
    Conserved Domains (1) summary
    pfam01284
    Location:168 → 312
    MARVEL; Membrane-associating domain

  6. NM_001290189.1 → NP_001277118.1  myeloid-associated differentiation marker

    See identical proteins and their annotated locations for NP_001277118.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) represents the longest transcript. All twelve variants encode the same protein.
    Source sequence(s)
    AC008440, AF087882, DB448983, HY124929
    Consensus CDS
    CCDS12866.1
    UniProtKB/Swiss-Prot
    B2RE58, Q542Z1, Q7Z507, Q8N9R4, Q96CS6, Q96S97, Q96SK9
    UniProtKB/TrEMBL
    B4DG42, E9PBN6
    Conserved Domains (1) summary
    pfam01284
    Location:168 → 312
    MARVEL; Membrane-associating domain

  7. NM_001290190.2 → NP_001277119.1  myeloid-associated differentiation marker

    See identical proteins and their annotated locations for NP_001277119.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) differs in the 5' UTR compared to variant 6. All twelve variants encode the same protein.
    Source sequence(s)
    AC008440, AF087882, DA677314
    Consensus CDS
    CCDS12866.1
    UniProtKB/Swiss-Prot
    B2RE58, Q542Z1, Q7Z507, Q8N9R4, Q96CS6, Q96S97, Q96SK9
    UniProtKB/TrEMBL
    B4DG42, E9PBN6
    Conserved Domains (1) summary
    pfam01284
    Location:168 → 312
    MARVEL; Membrane-associating domain

  8. NM_001290191.2 → NP_001277120.1  myeloid-associated differentiation marker

    See identical proteins and their annotated locations for NP_001277120.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9) differs in the 5' UTR compared to variant 6. All twelve variants encode the same protein.
    Source sequence(s)
    AC008440, AF087882, DA472260
    Consensus CDS
    CCDS12866.1
    UniProtKB/Swiss-Prot
    B2RE58, Q542Z1, Q7Z507, Q8N9R4, Q96CS6, Q96S97, Q96SK9
    UniProtKB/TrEMBL
    B4DG42, E9PBN6
    Conserved Domains (1) summary
    pfam01284
    Location:168 → 312
    MARVEL; Membrane-associating domain

  9. NM_001290192.2 → NP_001277121.1  myeloid-associated differentiation marker

    See identical proteins and their annotated locations for NP_001277121.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (10) differs in the 5' UTR compared to variant 6. All twelve variants encode the same protein.
    Source sequence(s)
    AC008440, AF087882, BQ716724, DA948116
    Consensus CDS
    CCDS12866.1
    UniProtKB/Swiss-Prot
    B2RE58, Q542Z1, Q7Z507, Q8N9R4, Q96CS6, Q96S97, Q96SK9
    UniProtKB/TrEMBL
    B4DG42, E9PBN6
    Conserved Domains (1) summary
    pfam01284
    Location:168 → 312
    MARVEL; Membrane-associating domain

  10. NM_001290193.2 → NP_001277122.1  myeloid-associated differentiation marker

    See identical proteins and their annotated locations for NP_001277122.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (11) differs in the 5' UTR compared to variant 6. All twelve variants encode the same protein.
    Source sequence(s)
    AC008440, AF087882, BQ430033
    Consensus CDS
    CCDS12866.1
    UniProtKB/Swiss-Prot
    B2RE58, Q542Z1, Q7Z507, Q8N9R4, Q96CS6, Q96S97, Q96SK9
    UniProtKB/TrEMBL
    B4DG42, E9PBN6
    Conserved Domains (1) summary
    pfam01284
    Location:168 → 312
    MARVEL; Membrane-associating domain

  11. NM_001290194.2 → NP_001277123.1  myeloid-associated differentiation marker

    See identical proteins and their annotated locations for NP_001277123.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (12) differs in the 5' UTR compared to variant 6. All twelve variants encode the same protein.
    Source sequence(s)
    AC008440, AF087882, AL524210, DA948116
    Consensus CDS
    CCDS12866.1
    UniProtKB/Swiss-Prot
    B2RE58, Q542Z1, Q7Z507, Q8N9R4, Q96CS6, Q96S97, Q96SK9
    UniProtKB/TrEMBL
    B4DG42, E9PBN6
    Related
    ENSP00000416919.1, ENST00000439000.5
    Conserved Domains (1) summary
    pfam01284
    Location:168 → 312
    MARVEL; Membrane-associating domain

  12. NM_138373.5 → NP_612382.1  myeloid-associated differentiation marker

    See identical proteins and their annotated locations for NP_612382.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 6. All twelve variants encode the same protein.
    Source sequence(s)
    AC008440, AF087882, DA948116
    Consensus CDS
    CCDS12866.1
    UniProtKB/Swiss-Prot
    B2RE58, Q542Z1, Q7Z507, Q8N9R4, Q96CS6, Q96S97, Q96SK9
    UniProtKB/TrEMBL
    B4DG42, E9PBN6
    Related
    ENSP00000375650.4, ENST00000391770.9
    Conserved Domains (1) summary
    pfam01284
    Location:168 → 312
    MARVEL; Membrane-associating domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    53865628..53876435
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    56945407..56956143
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96S97.2 GenPept UniProtKB/Swiss-Prot:Q96S97

Gene LinkOut

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