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DYRK1B dual specificity tyrosine phosphorylation regulated kinase 1B [ Homo sapiens (human) ]

Gene ID: 9149, updated on 3-Apr-2024

Summary

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Official Symbol
DYRK1Bprovided by HGNC
Official Full Name
dual specificity tyrosine phosphorylation regulated kinase 1Bprovided by HGNC
Primary source
HGNC:HGNC:3092
See related
Ensembl:ENSG00000105204 MIM:604556; AllianceGenome:HGNC:3092
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MIRK; AOMS3
Summary
This gene encodes a member of a family of nuclear-localized protein kinases. The encoded protein participates in the regulation of the cell cycle. Expression of this gene may be altered in tumor cells, and mutations in this gene were found to cause abdominal obesity-metabolic syndrome 3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]
Expression
Broad expression in testis (RPKM 21.5), prostate (RPKM 4.7) and 23 other tissues See more
Orthologs
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Genomic context

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Location:
19q13.2
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (39825350..39834162, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (42630272..42639084, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (40315990..40324802, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene leucine twenty homeobox Neighboring gene uncharacterized LOC124904719 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:40314468-40315454 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:40315455-40316439 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10613 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10614 Neighboring gene microRNA 6719 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:40335824-40336564 Neighboring gene fibrillarin Neighboring gene MED14-independent group 3 enhancer GRCh37_chr19:40357069-40358268 Neighboring gene Fc gamma binding protein Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:40376357-40376858 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:40433231-40433732

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Study of DYRK1B gene expression and its association with metabolic syndrome in a small cohort of Egyptians. Mohamed YA, et al. Mol Biol Rep, 2021 Jul. PMID 34291393
  2. Screen identifies DYRK1B network as mediator of transcription repression on damaged chromatin. Dong C, et al. Proc Natl Acad Sci U S A, 2020 Jul 21. PMID 32611815, Free PMC Article
  3. DYRK1B mutations associated with metabolic syndrome impair the chaperone-dependent maturation of the kinase domain. Abu Jhaisha S, et al. Sci Rep, 2017 Jul 25. PMID 28743892, Free PMC Article
  4. Dyrk1B overexpression is associated with breast cancer growth and a poor prognosis. Chen Y, et al. Hum Pathol, 2017 Aug. PMID 28554575
  5. Mirk/dyrk1B kinase is upregulated following inhibition of mTOR. Deng X, et al. Carcinogenesis, 2014 Sep. PMID 24590896, Free PMC Article

See all (73) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Pathogenic, Total Loss-of-Function DYRK1B Variants Cause Monogenic Obesity Associated With Type 2 Diabetes.
    Title: Pathogenic, Total Loss-of-Function DYRK1B Variants Cause Monogenic Obesity Associated With Type 2 Diabetes.
  2. Targeting the survival kinase DYRK1B: A novel approach to overcome radiotherapy-related treatment resistance.
    Title: Targeting the survival kinase DYRK1B: A novel approach to overcome radiotherapy-related treatment resistance.
  3. Analysis of DYRK1B, PPARG, and CEBPB Expression Patterns in Adipose-Derived Stem Cells from Patients Carrying DYRK1B R102C and Healthy Individuals During Adipogenesis.
    Title: Analysis of DYRK1B, PPARG, and CEBPB Expression Patterns in Adipose-Derived Stem Cells from Patients Carrying DYRK1B R102C and Healthy Individuals During Adipogenesis.
  4. DYRK1B-STAT3 Drives Cardiac Hypertrophy and Heart Failure by Impairing Mitochondrial Bioenergetics.
    Title: DYRK1B-STAT3 Drives Cardiac Hypertrophy and Heart Failure by Impairing Mitochondrial Bioenergetics.
  5. Differential maturation and chaperone dependence of the paralogous protein kinases DYRK1A and DYRK1B.
    Title: Differential maturation and chaperone dependence of the paralogous protein kinases DYRK1A and DYRK1B.
  6. Suppression of DYRK1A/B Drives Endoplasmic Reticulum Stress-mediated Autophagic Cell Death Through Metabolic Reprogramming in Colorectal Cancer Cells.
    Title: Suppression of DYRK1A/B Drives Endoplasmic Reticulum Stress-mediated Autophagic Cell Death Through Metabolic Reprogramming in Colorectal Cancer Cells.
  7. Study of DYRK1B gene expression and its association with metabolic syndrome in a small cohort of Egyptians.
    Title: Study of DYRK1B gene expression and its association with metabolic syndrome in a small cohort of Egyptians.
  8. Screen identifies DYRK1B network as mediator of transcription repression on damaged chromatin.
    Title: Screen identifies DYRK1B network as mediator of transcription repression on damaged chromatin.
  9. Proline Hydroxylation Primes Protein Kinases for Autophosphorylation and Activation.
    Title: Proline Hydroxylation Primes Protein Kinases for Autophosphorylation and Activation.
  10. Human cytomegalovirus(HCMV) modulates cellular dual specificity tyrosine phosphorylation regulated kinase 1B (DYRK1B) during placental replication which may have implications for congenital HCMV pathogenesis and represent promising antiviral targets.
    Title: Human cytomegalovirus utilises cellular dual-specificity tyrosine phosphorylation-regulated kinases during placental replication.
Submit: New GeneRIF Correction See all GeneRIFs (33)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Abdominal obesity-metabolic syndrome 3
MedGen: C4014361 OMIM: 615812 GeneReviews: Not available
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Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine/tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables transcription coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transcription coactivator activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
  
involved_in adipose tissue development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in myoblast fusion IEA
Inferred from Electronic Annotation
more info
  
involved_in peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in peptidyl-threonine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in chromosome IDA
Inferred from Direct Assay
more info
  
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
dual specificity tyrosine-phosphorylation-regulated kinase 1B
Names
dual specificity tyrosine-(Y)-phosphorylation regulated kinase 1B
minibrain-related kinase
mirk protein kinase
NP_004705.1
NP_006474.1
NP_006475.1
XP_005259455.1
XP_047295623.1
XP_047295624.1
XP_047295625.1
XP_054178558.1
XP_054178559.1
XP_054178560.1
XP_054178561.1
XP_054187621.1
XP_054187622.1
XP_054187623.1
XP_054187624.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_034145.1 RefSeqGene

    Range
    5072..13884
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_004714.3 → NP_004705.1  dual specificity tyrosine-phosphorylation-regulated kinase 1B isoform p69

    See identical proteins and their annotated locations for NP_004705.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1, also known as 'a') represents the longest transcript and encodes the longest isoform (p69, also known as isoform a).
    Source sequence(s)
    Y17999
    Consensus CDS
    CCDS12543.1
    UniProtKB/Swiss-Prot
    O75258, O75788, O75789, Q9Y463
    UniProtKB/TrEMBL
    B3KQI0
    Related
    ENSP00000312789.4, ENST00000323039.10
    Conserved Domains (1) summary
    cd14226
    Location:97 → 436
    PKc_DYRK1; Catalytic domain of the protein kinase, Dual-specificity tYrosine-phosphorylated and -Regulated Kinase 1

  2. NM_006483.3 → NP_006474.1  dual specificity tyrosine-phosphorylation-regulated kinase 1B isoform p65

    See identical proteins and their annotated locations for NP_006474.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2, also known as 'b') uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The encoded isoform (p65, also known as isoform b) is shorter than isoform p69.
    Source sequence(s)
    BI964831, Y17999
    Consensus CDS
    CCDS46075.1
    UniProtKB/TrEMBL
    B3KQI0
    Related
    ENSP00000403182.1, ENST00000430012.6
    Conserved Domains (1) summary
    cd14226
    Location:97 → 396
    PKc_DYRK1; Catalytic domain of the protein kinase, Dual-specificity tYrosine-phosphorylated and -Regulated Kinase 1

  3. NM_006484.3 → NP_006475.1  dual specificity tyrosine-phosphorylation-regulated kinase 1B isoform p66

    See identical proteins and their annotated locations for NP_006475.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3, also known as 'c') lacks an alternate in-frame segment in the 3' coding region, compared to variant 1. The encoded isoform (p66, also known as isoform c) is shorter than isoform p69.
    Source sequence(s)
    BI964831, Y17999
    Consensus CDS
    CCDS12544.1
    UniProtKB/TrEMBL
    B3KQI0
    Related
    ENSP00000221803.4, ENST00000348817.7
    Conserved Domains (1) summary
    cd14226
    Location:97 → 408
    PKc_DYRK1; Catalytic domain of the protein kinase, Dual-specificity tYrosine-phosphorylated and -Regulated Kinase 1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    39825350..39834162 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047439669.1 → XP_047295625.1  dual specificity tyrosine-phosphorylation-regulated kinase 1B isoform X3

  2. XM_047439668.1 → XP_047295624.1  dual specificity tyrosine-phosphorylation-regulated kinase 1B isoform X2

  3. XM_047439667.1 → XP_047295623.1  dual specificity tyrosine-phosphorylation-regulated kinase 1B isoform X1

    UniProtKB/TrEMBL
    A0A9H4CVU7
    Related
    ENSP00000469863.2, ENST00000593685.5

  4. XM_005259398.5 → XP_005259455.1  dual specificity tyrosine-phosphorylation-regulated kinase 1B isoform X4

    See identical proteins and their annotated locations for XP_005259455.1

    UniProtKB/Swiss-Prot
    O75258, O75788, O75789, Q9Y463
    UniProtKB/TrEMBL
    B3KQI0
    Conserved Domains (1) summary
    cd14226
    Location:97 → 436
    PKc_DYRK1; Catalytic domain of the protein kinase, Dual-specificity tYrosine-phosphorylated and -Regulated Kinase 1

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_009646206.1 Reference GRCh38.p14 PATCHES

    Range
    85226..94038 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054331646.1 → XP_054187621.1  dual specificity tyrosine-phosphorylation-regulated kinase 1B isoform X1

    UniProtKB/TrEMBL
    A0A9H4CVU7

  2. XM_054331647.1 → XP_054187622.1  dual specificity tyrosine-phosphorylation-regulated kinase 1B isoform X2

  3. XM_054331648.1 → XP_054187623.1  dual specificity tyrosine-phosphorylation-regulated kinase 1B isoform X3

  4. XM_054331649.1 → XP_054187624.1  dual specificity tyrosine-phosphorylation-regulated kinase 1B isoform X4

    UniProtKB/Swiss-Prot
    O75258, O75788, O75789, Q9Y463

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    42630272..42639084 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054322583.1 → XP_054178558.1  dual specificity tyrosine-phosphorylation-regulated kinase 1B isoform X1

    UniProtKB/TrEMBL
    A0A9H4CVU7

  2. XM_054322584.1 → XP_054178559.1  dual specificity tyrosine-phosphorylation-regulated kinase 1B isoform X2

  3. XM_054322585.1 → XP_054178560.1  dual specificity tyrosine-phosphorylation-regulated kinase 1B isoform X3

  4. XM_054322586.1 → XP_054178561.1  dual specificity tyrosine-phosphorylation-regulated kinase 1B isoform X4

    UniProtKB/Swiss-Prot
    O75258, O75788, O75789, Q9Y463
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Y463.1 GenPept UniProtKB/Swiss-Prot:Q9Y463

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