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POLY polyprotein;truncated polyprotein NS1 prime [ West Nile virus ]

Gene ID: 912267, updated on 18-Aug-2023

Summary

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Gene symbol
POLY
Gene description
polyprotein;truncated polyprotein NS1 prime
Locus tag
WNVgp1
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
West Nile virus (strain: 956)
Lineage
Viruses; Riboviria; Flaviviridae; Flavivirus
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Genomic context

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Location:
clone: 33/G8; 34/F6
Sequence:
NC_001563.2 (97..10389)

NC_001563.2Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001563.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The two-component NS2B-NS3 proteinase represses DNA unwinding activity of the West Nile virus NS3 helicase. Chernov AV, et al. J Biol Chem, 2008 Jun 20. PMID 18442976, Free PMC Article
  2. Sequence analysis of the viral core protein and the membrane-associated proteins V1 and NV2 of the flavivirus West Nile virus and of the genome sequence for these proteins. Castle E, et al. Virology, 1985 Sep. PMID 2992152
  3. Primary structure of the West Nile flavivirus genome region coding for all nonstructural proteins. Castle E, et al. Virology, 1986 Feb. PMID 3753811
  4. Sequence analysis of the membrane protein V3 of the flavivirus West Nile virus and of its gene. Wengler G, et al. Virology, 1985 Dec. PMID 3855247
  5. An infectious clone of the West Nile flavivirus. Yamshchikov VF, et al. Virology, 2001 Mar 15. PMID 11277701

See all (44) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Amino acid 159 of the envelope protein affects viral replication and T-cell infiltration by West Nile virus in intracranial infection.
    Title: Amino acid 159 of the envelope protein affects viral replication and T-cell infiltration by West Nile virus in intracranial infection.
  2. This study thus shows for the first time that nuclear localization sequence-dependent trafficking into the nucleus during infection of Kunjin virus NS5 is critical for viral replication.
    Title: Nucleocytoplasmic shuttling of the West Nile virus RNA-dependent RNA polymerase NS5 is critical to infection.
  3. This study portrayed the non-structural function of C protein that helped the flavivirus to nullify the antiviral activity of hSec3p by accelerating its degradation and facilitating efficient binding of elongation factor 1alpha with flaviviral RNA genome.
    Title: West Nile virus and dengue virus capsid protein negates the antiviral activity of human Sec3 protein through the proteasome pathway.
  4. evidence of the intrinsic flexibility and conformational heterogeneity of the NS2B chain of the WNV protease in the absence of substratelike ligands, which should be considered during antiviral drug discovery and development efforts
    Title: Intrinsic flexibility of West Nile virus protease in solution characterized using small-angle X-ray scattering.
  5. Mass spectrometry and coimmunoprecipitation studies established a novel physical interaction between NS1 and NS4B, suggesting a mechanism for how luminal NS1 conveys signals to the cytoplasm to regulate RNA replication.
    Title: Evidence for a genetic and physical interaction between nonstructural proteins NS1 and NS4B that modulates replication of West Nile virus.
  6. NS4B P38G substitution was associated with both temperature-sensitive and small-plaque phenotypes.
    Title: Mutational analysis of the West Nile virus NS4B protein.
  7. KAWGKSILFA is a novel epitope of NS1 protein recognized by the NS1 mAb.
    Title: A cross-protective mAb recognizes a novel epitope within the flavivirus NS1 protein.
  8. West Nile virus specific B-cell epitopes located at aa 21-36, 101-116, 191-206 and 261-276 of NS1.
    Title: Comprehensive mapping of West Nile virus (WNV)- and Japanese encephalitis virus serocomplex-specific linear B-cell epitopes from WNV non-structural protein 1.
  9. Structural protein, prME, dictates the growth differences of St Louis encephalitis virus and West Nile virus.
    Title: Structural gene (prME) chimeras of St Louis encephalitis virus and West Nile virus exhibit altered in vitro cytopathic and growth phenotypes.
  10. The combined effects of proline and negatively charged residues within the PEPE peptide are essential to promote the cleavage of 2K from NS4A, which is a prerequisite for efficient West Nile virus replication.
    Title: A conserved peptide in West Nile virus NS4A protein contributes to proteolytic processing and is essential for replication.
Submit: New GeneRIF Correction See all GeneRIFs (38)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General protein information

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Preferred Names
polyprotein;truncated polyprotein NS1 prime
Names
capsid protein C
anchored capsid protein ancC
membrane glycoprotein precursor prM
membrane glycoprotein M
envelope protein E
nonstructural protein NS1
nonstructural protein NS2A
nonstructural protein NS2B
nonstructural protein NS3
nonstructural protein NS4A
protein 2K
nonstructural protein NS4B
RNA-dependent RNA polymerase NS5
protein pr
nonstructural protein NS1 prime
YP_009164950.1
  • NS1' protein; transframe fusion protein expressed via programmed ribosomal frameshifting; when frameshifting occurs, cleavage between NS1 and NS2A fails to occur

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001563.2 Reference assembly

    Range
    97..10389
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_041724.2 polyprotein [West Nile virus]

    See identical proteins and their annotated locations for NP_041724.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P06935
    UniProtKB/TrEMBL
    Q5MXE3
    Conserved Domains (20) summary
    pfam01003
    Location:6 → 105
    Flavi_capsid; Flavivirus capsid protein C
    pfam01003
    Location:6 → 123
    Flavi_capsid; Flavivirus capsid protein C
    pfam01004
    Location:98 → 167
    Flavi_M; Flavivirus envelope glycoprotein M
    pfam01570
    Location:7 → 81
    Flavi_propep; Flavivirus polyprotein propeptide
    pfam01004
    Location:6 → 75
    Flavi_M; Flavivirus envelope glycoprotein M
    cd12149
    Location:304 → 396
    Flavi_E_C; Immunoglobulin-like domain III (C-terminal domain) of Flavivirus envelope glycoprotein E
    TIGR04240
    Location:401 → 497
    flavi_E_stem; flavivirus envelope glycoprotein E, stem/anchor domain
    pfam00869
    Location:3 → 295
    Flavi_glycoprot; Flavivirus glycoprotein, central and dimerization domains
    pfam00948
    Location:2 → 352
    Flavi_NS1; Flavivirus non-structural Protein NS1
    pfam01005
    Location:12 → 164
    Flavi_NS2A; Flavivirus non-structural protein NS2A
    pfam01002
    Location:6 → 131
    Flavi_NS2B; Flavivirus non-structural protein NS2B
    smart00487
    Location:181 → 326
    DEXDc; DEAD-like helicases superfamily
    pfam00949
    Location:19 → 167
    Peptidase_S7; Peptidase S7, Flavivirus NS3 serine protease
    pfam07652
    Location:186 → 331
    Flavi_DEAD; Flavivirus DEAD domain
    cl21455
    Location:357 → 465
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    pfam01350
    Location:5 → 126
    Flavi_NS4A; Flavivirus non-structural protein NS4A
    pfam01349
    Location:1 → 247
    Flavi_NS4B; Flavivirus non-structural protein NS4B
    pfam00972
    Location:254 → 894
    Flavi_NS5; Flavivirus RNA-directed RNA polymerase
    pfam01728
    Location:55 → 223
    FtsJ; FtsJ-like methyltransferase
    pfam01570
    Location:7 → 91
    Flavi_propep; Flavivirus polyprotein propeptide

  2. YP_009164950.1 truncated flavivirus polyprotein NS1 prime [West Nile virus]

    Status: PROVISIONAL

    Conserved Domains (7) summary
    cd12149
    Location:594 → 686
    Flavi_E_C; Immunoglobulin-like domain III (C-terminal domain) of Flavivirus envelope glycoprotein E
    TIGR04240
    Location:691 → 787
    flavi_E_stem; flavivirus envelope glycoprotein E, stem/anchor domain
    pfam01003
    Location:6 → 123
    Flavi_capsid; Flavivirus capsid protein C
    pfam00869
    Location:293 → 585
    Flavi_glycoprot; Flavivirus glycoprotein, central and dimerization domains
    pfam00948
    Location:789 → 1139
    Flavi_NS1; Flavivirus non-structural Protein NS1
    pfam01004
    Location:221 → 290
    Flavi_M; Flavivirus envelope glycoprotein M
    pfam01570
    Location:130 → 204
    Flavi_propep; Flavivirus polyprotein propeptide

  3. YP_009164952.1 nonstructural protein NS1 prime

    Conserved Domains (1) summary
    pfam00948
    Location:2 → 352
    Flavi_NS1; Flavivirus non-structural Protein NS1
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P06935.2

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