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VP30 minor nucleoprotein [ Zaire ebolavirus ]

Gene ID: 911826, updated on 22-Sep-2023

Summary

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Gene symbol
VP30
Gene description
minor nucleoprotein
Locus tag
ZEBOVgp5
Gene type
protein coding
RNA name
VP30
RefSeq status
PROVISIONAL
Organism
Zaire ebolavirus (isolate: Ebola virus/H.sapiens-tc/COD/1976/Yambuku-Mayinga)
Lineage
Viruses; ssRNA viruses; ssRNA negative-strand viruses; Mononegavirales; Filoviridae; Ebolavirus
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Genomic context

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Sequence:
NC_002549.1 (8288..9740)

NC_002549.1Genomic Context describing neighboring genes Neighboring gene nucleoprotein Neighboring gene polymerase complex protein Neighboring gene matrix protein Neighboring gene second secreted glycoprotein;small secreted glycoprotein;spike glycoprotein Neighboring gene membrane-associated protein Neighboring gene RNA-dependent RNA polymerase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_002549.1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Ebola virus VP30 and nucleoprotein interactions modulate viral RNA synthesis. Xu W, et al. Nat Commun, 2017 Jun 8. PMID 28593988, Free PMC Article
  2. Role of protein phosphatase 1 in dephosphorylation of Ebola virus VP30 protein and its targeting for the inhibition of viral transcription. Ilinykh PA, et al. J Biol Chem, 2014 Aug 15. PMID 24936058, Free PMC Article
  3. Phosphorylation of VP30 impairs ebola virus transcription. Modrof J, et al. J Biol Chem, 2002 Sep 6. PMID 12052831
  4. Role of Ebola virus VP30 in transcription reinitiation. Martínez MJ, et al. J Virol, 2008 Dec. PMID 18829754, Free PMC Article
  5. How Ebola and Marburg viruses battle the immune system. Mohamadzadeh M, et al. Nat Rev Immunol, 2007 Jul. PMID 17589545

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Functional analyses of the eVP30-nucleoprotein interface identify residues that are critical for viral RNA synthesis. Altogether, these results support a model where the eVP30-nucleoprotein interaction plays a critical role in transcription initiation and provides a novel target for the development of antiviral therapy.
    Title: Ebola virus VP30 and nucleoprotein interactions modulate viral RNA synthesis.
  2. Comparison of the percentage of disorder (PID) in nucleocapsid proteins VP30 and NP reveals high correlation between nucleocapsid PIDs and the case-fatality rates of Ebola virus .
    Title: Detection of links between Ebola nucleocapsid and virulence using disorder analysis.
  3. mutations of Thr(143) and Thr(146) of VP30 significantly inhibited EBOV transcription and strongly induced VP30 phosphorylation in the N-terminal Ser residues 29-46, suggesting a novel mechanism of regulation of VP30 phosphorylation.
    Title: Role of protein phosphatase 1 in dephosphorylation of Ebola virus VP30 protein and its targeting for the inhibition of viral transcription.
  4. In addition to viral protein 35 (VP35), we found that VP30 and VP40 independently act as suppressor of RNA silencing.
    Title: Ebolavirus proteins suppress the effects of small interfering RNA by direct interaction with the mammalian RNA interference pathway.
  5. VP30 is involved in reinitiation of gene transcription and that this activity is affected by mutations at the phosphorylation sites.
    Title: Role of Ebola virus VP30 in transcription reinitiation.
  6. Study shows for the first time the direct interaction of EBOV VP30 with RNA and the importance of the N-terminal region for binding RNA.
    Title: Ebola virus VP30 is an RNA binding protein.
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General gene information

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Homology

regulatory

  • Loc: 8288-8299 regulatory_class = other
  • Loc: 8295-8305 regulatory_class = polyA_signal_sequence
  • Loc: 9730-9740 regulatory_class = polyA_signal_sequence

General protein information

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Preferred Names
minor nucleoprotein
NP_066249.1
  • polymerase complex protein

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_002549.1 Reference assembly

    Range
    8288..9740
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_066249.1 minor nucleoprotein [Zaire ebolavirus]

    See identical proteins and their annotated locations for NP_066249.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    Q05323, Q77DJ5, Q9YMG1
    UniProtKB/TrEMBL
    A0A0E3KX28, A0A0E3XKF2, A0A0F6PD42, A0A0F6PD98, A0A0F6PE67, A0A0F7IML9, A0A0G2Y938, A0A0G2YEX8, A0A0K1NY97, A0A0S0H5G2, A0A0S0HCX3, A0A0U3V2Q4, A0A0U3V2T6, A0A0U3VJZ0, A0A0U4CS06, A0A0U4D596, A0A0U4E233, A0A1X9IWG5, A0A3G2LMC4, A0A3Q8HH29, A0A3Q8HQ01, A0A3S7SM57, A0A3S7SQS1, A0A7S6GEX9, A0A7S6GF39, A0A7S6GGU9, A0A7S6KAL7, A9QPM2
    Conserved Domains (1) summary
    pfam11507
    Location:142 → 271
    Transcript_VP30; Ebola virus-specific transcription factor VP30
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
AAD14587.1

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