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L RNA-dependent RNA polymerase [ Zaire ebolavirus ]

Gene ID: 911824, updated on 18-Aug-2023

Summary

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Gene symbol
L
Gene description
RNA-dependent RNA polymerase
Locus tag
ZEBOVgp7
Gene type
protein coding
RNA name
polymerase
RefSeq status
PROVISIONAL
Organism
Zaire ebolavirus (isolate: Ebola virus/H.sapiens-tc/COD/1976/Yambuku-Mayinga)
Lineage
Viruses; ssRNA viruses; ssRNA negative-strand viruses; Mononegavirales; Filoviridae; Ebolavirus
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Genomic context

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Sequence:
NC_002549.1 (11501..18282)

NC_002549.1Genomic Context describing neighboring genes Neighboring gene polymerase complex protein Neighboring gene matrix protein Neighboring gene second secreted glycoprotein;small secreted glycoprotein;spike glycoprotein Neighboring gene minor nucleoprotein Neighboring gene membrane-associated protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_002549.1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The complete nucleotide sequence of the Popp (1967) strain of Marburg virus: a comparison with the Musoke (1980) strain. Bukreyev AA, et al. Arch Virol, 1995. PMID 7487490
  2. Ebola virus inhibits induction of genes by double-stranded RNA in endothelial cells. Harcourt BH, et al. Virology, 1998 Dec 5. PMID 9875327
  3. DNA topoisomerase 1 facilitates the transcription and replication of the Ebola virus genome. Takahashi K, et al. J Virol, 2013 Aug. PMID 23658456, Free PMC Article
  4. The L-VP35 and L-L interaction domains reside in the amino terminus of the Ebola virus L protein and are potential targets for antivirals. Trunschke M, et al. Virology, 2013 Jul 5. PMID 23582637, Free PMC Article
  5. Remdesivir targets a structurally analogous region of the Ebola virus and SARS-CoV-2 polymerases. Lo MK, et al. Proc Natl Acad Sci U S A, 2020 Oct 27. PMID 33028676, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Remdesivir targets a structurally analogous region of the Ebola virus and SARS-CoV-2 polymerases.
    Title: Remdesivir targets a structurally analogous region of the Ebola virus and SARS-CoV-2 polymerases.
  2. Authors found that the phosphodiester bridge-cleaving and recombination activities of TOP1 are required for the polymerase activity of Ebola virus L protein.
    Title: DNA topoisomerase 1 facilitates the transcription and replication of the Ebola virus genome.
  3. A core binding domain spanning amino acids 280-370 of L was sufficient to mediate weak interaction with VP35, while the entire N-terminus up to amino acid 380 was required for strong VP35-L binding.
    Title: The L-VP35 and L-L interaction domains reside in the amino terminus of the Ebola virus L protein and are potential targets for antivirals.
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General gene information

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regulatory

  • Loc: 11501-11512 regulatory_class = other
  • Loc: 11508-11518 regulatory_class = polyA_signal_sequence
  • Loc: 18272-18282 regulatory_class = polyA_signal_sequence

General protein information

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Preferred Names
RNA-dependent RNA polymerase

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_002549.1 Reference assembly

    Range
    11501..18282
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_066251.1 RNA-dependent RNA polymerase [Zaire ebolavirus]

    See identical proteins and their annotated locations for NP_066251.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    O39794, Q05318, Q773N0, Q8JS59, Q9DQD1
    UniProtKB/TrEMBL
    A0A0E3KN53, A0A0U3A3F9, A9QPM4, L7QHR8
    Conserved Domains (3) summary
    TIGR04198
    Location:1215 → 2204
    paramyx_RNAcap; mRNA capping enzyme, paramyxovirus family
    pfam00946
    Location:10 → 1089
    Mononeg_RNA_pol; Mononegavirales RNA dependent RNA polymerase
    pfam14318
    Location:1105 → 1357
    Mononeg_mRNAcap; Mononegavirales mRNA-capping region V
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
AAD14589.1

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