U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

NMI N-myc and STAT interactor [ Homo sapiens (human) ]

Gene ID: 9111, updated on 11-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
NMIprovided by HGNC
Official Full Name
N-myc and STAT interactorprovided by HGNC
Primary source
HGNC:HGNC:7854
See related
Ensembl:ENSG00000123609 MIM:603525; AllianceGenome:HGNC:7854
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
NMYC interactor (NMI) encodes a protein that interacts with NMYC and CMYC (two members of the oncogene Myc family), and other transcription factors containing a Zip, HLH, or HLH-Zip motif. The NMI protein also interacts with all STATs except STAT2 and augments STAT-mediated transcription in response to cytokines IL2 and IFN-gamma. The NMI mRNA has low expression levels in all human fetal and adult tissues tested except brain and has high expression in cancer cell line-myeloid leukemias. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in appendix (RPKM 16.7), bone marrow (RPKM 15.4) and 24 other tissues See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
2q23.3
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (151270470..151289668, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (151722213..151741416, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (152126984..152146182, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene fatty acid binding protein 5 pseudogene 10 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12005 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16629 Neighboring gene RNA binding motif protein 43 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16630 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16631 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16633 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12006 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16632 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16634 Neighboring gene uncharacterized LOC107985827 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16635 Neighboring gene uncharacterized LOC101929319 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr2:152195619-152196139 Neighboring gene TNF alpha induced protein 6 Neighboring gene microRNA 4773-1 Neighboring gene microRNA 4773-2

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. N-myc-interactor mediates microbiome induced epithelial to mesenchymal transition and is associated with chronic lung allograft dysfunction. Banday MM, et al. J Heart Lung Transplant, 2021 Jun. PMID 33781665
  2. N-myc and STAT interactor correlates with severity and prognosis in acute-on-chronic liver failure of hepatitis B virus. Xiong L, et al. J Gastroenterol Hepatol, 2019 Oct. PMID 30771232, Free PMC Article
  3. N-Myc-Interacting Protein Negatively Regulates TNF-α-Induced NF-κB Transcriptional Activity by Sequestering NF-κB/p65 in the Cytoplasm. Hou J, et al. Sci Rep, 2017 Nov 6. PMID 29109532, Free PMC Article
  4. Downregulation of NMI promotes tumor growth and predicts poor prognosis in human lung adenocarcinomas. Wang J, et al. Mol Cancer, 2017 Oct 12. PMID 29025423, Free PMC Article
  5. N-Myc and STAT Interactor regulates autophagy and chemosensitivity in breast cancer cells. Metge BJ, et al. Sci Rep, 2015 Jul 6. PMID 26146406, Free PMC Article

See all (78) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. NMI promotes tumor progression and gemcitabine resistance in pancreatic cancer via STAT3-IFIT3 axis.
    Title: NMI promotes tumor progression and gemcitabine resistance in pancreatic cancer via STAT3-IFIT3 axis.
  2. N-myc-interactor mediates microbiome induced epithelial to mesenchymal transition and is associated with chronic lung allograft dysfunction.
    Title: N-myc-interactor mediates microbiome induced epithelial to mesenchymal transition and is associated with chronic lung allograft dysfunction.
  3. IFP35 family proteins promote neuroinflammation and multiple sclerosis.
    Title: IFP35 family proteins promote neuroinflammation and multiple sclerosis.
  4. NMI promotes cell proliferation through TGFbeta/Smad pathway by upregulating STAT1 in colorectal cancer.
    Title: NMI promotes cell proliferation through TGFβ/Smad pathway by upregulating STAT1 in colorectal cancer.
  5. Elevated serum NMI (>/= 198.5 pg/mL) was correlated with poor survival rate of acute-on-chronic liver failure of hepatitis B virus patients.
    Title: N-myc and STAT interactor correlates with severity and prognosis in acute-on-chronic liver failure of hepatitis B virus.
  6. Negatively Regulates TNF-alpha-Induced NF-kappaB Transcriptional Activity by Sequestering NF-kappaB/p65 in the Cytoplasm
    Title: N-Myc-Interacting Protein Negatively Regulates TNF-α-Induced NF-κB Transcriptional Activity by Sequestering NF-κB/p65 in the Cytoplasm.
  7. NMI and RAC1 might represent two new key genes related to gastric cancer
    Title: Multi-marker analysis of genomic annotation on gastric cancer GWAS data from Chinese populations.
  8. Nmi has a distinct role in the differentiation process of mammary luminal epithelial cell compartment and developmental aberrations resulting from Nmi absence contribute to metastasis.
    Title: Conditional knockout of N-Myc and STAT interactor disrupts normal mammary development and enhances metastatic ability of mammary tumors.
  9. These results revealed that IRF-1 is involved in the IFN-inducible expression of Nmi.
    Title: Interferon activates promoter of Nmi gene via interferon regulator factor-1.
  10. Our study showed that NMI suppressed tumor growth by inhibiting PI3K/AKT, MMP2/MMP9, COX-2/PGE2 signaling pathways and p300-mediated NF-kappaB acetylation, and predicted a favorable prognosis in human lung adenocarcinomas, suggesting that NMI was a potential tumor suppressor in lung cancer.
    Title: Downregulation of NMI promotes tumor growth and predicts poor prognosis in human lung adenocarcinomas.
Submit: New GeneRIF Correction See all GeneRIFs (32)

Phenotypes

Go to the top of the page Help

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

Go to the top of the page Help

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat downregulates N-myc (and STAT) interactor in HEK 293T cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell surface receptor signaling pathway via JAK-STAT TAS
Traceable Author Statement
more info
 PubMed 
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in macrophage activation involved in immune response IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of innate immune response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of interferon-alpha production IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of interferon-beta production IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of non-canonical NF-kappaB signal transduction IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of inflammatory response ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of innate immune response ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of non-canonical NF-kappaB signal transduction IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of protein K48-linked ubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in protein K48-linked ubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in response to virus ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in toll-like receptor 4 signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
N-myc-interactor

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_004688.3 → NP_004679.2  N-myc-interactor

    See identical proteins and their annotated locations for NP_004679.2

    Status: REVIEWED

    Source sequence(s)
    BC001268, BC021987, CB151555
    Consensus CDS
    CCDS2192.1
    UniProtKB/Swiss-Prot
    B5BU69, Q13287, Q53TI8, Q8WTW2, Q9BVE5
    UniProtKB/TrEMBL
    A8K683
    Related
    ENSP00000243346.5, ENST00000243346.10
    Conserved Domains (3) summary
    cd12544
    Location:157 → 237
    RRM_NMI; RNA recognition motif in N-myc-interactor (Nmi) and similar proteins
    pfam07292
    Location:203 → 291
    NID; Nmi/IFP 35 domain (NID)
    pfam07334
    Location:29 → 104
    IFP_35_N; Interferon-induced 35 kDa protein (IFP 35) N-terminus

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    151270470..151289668 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005246941.3 → XP_005246998.1  N-myc-interactor isoform X2

    See identical proteins and their annotated locations for XP_005246998.1

    UniProtKB/Swiss-Prot
    B5BU69, Q13287, Q53TI8, Q8WTW2, Q9BVE5
    UniProtKB/TrEMBL
    A8K683
    Conserved Domains (3) summary
    cd12544
    Location:157 → 237
    RRM_NMI; RNA recognition motif in N-myc-interactor (Nmi) and similar proteins
    pfam07292
    Location:203 → 291
    NID; Nmi/IFP 35 domain (NID)
    pfam07334
    Location:29 → 104
    IFP_35_N; Interferon-induced 35 kDa protein (IFP 35) N-terminus

  2. XM_047446270.1 → XP_047302226.1  N-myc-interactor isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    151722213..151741416 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054344474.1 → XP_054200449.1  N-myc-interactor isoform X2

  2. XM_054344473.1 → XP_054200448.1  N-myc-interactor isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q13287.2 GenPept UniProtKB/Swiss-Prot:Q13287

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous