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PKMYT1 protein kinase, membrane associated tyrosine/threonine 1 [ Homo sapiens (human) ]

Gene ID: 9088, updated on 3-Apr-2024

Summary

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Official Symbol
PKMYT1provided by HGNC
Official Full Name
protein kinase, membrane associated tyrosine/threonine 1provided by HGNC
Primary source
HGNC:HGNC:29650
See related
Ensembl:ENSG00000127564 MIM:602474; AllianceGenome:HGNC:29650
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MYT1; PPP1R126
Summary
This gene encodes a member of the serine/threonine protein kinase family. The encoded protein is a membrane-associated kinase that negatively regulates the G2/M transition of the cell cycle by phosphorylating and inactivating cyclin-dependent kinase 1. The activity of the encoded protein is regulated by polo-like kinase 1. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012]
Expression
Broad expression in testis (RPKM 14.8), bone marrow (RPKM 10.4) and 16 other tissues See more
Orthologs
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Genomic context

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Location:
16p13.3
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (2972808..2980446, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (2999487..3007174, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (3022809..3030447, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene FLYWCH-type zinc finger 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:2988192-2988805 Neighboring gene uncharacterized LOC105371055 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:3005307-3006228 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:3006229-3007148 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10287 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:3011513-3012510 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:3012511-3013508 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7088 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7089 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:3015093-3016052 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:3018331-3019320 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7092 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7093 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7094 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7095 Neighboring gene kringle containing transmembrane protein 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:3021603-3022419 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:3029137-3030013 Neighboring gene progestin and adipoQ receptor family member 4 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:3030014-3030889 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:3030890-3031766 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:3032811-3033312 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7098 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:3033737-3033923 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:3037455-3038406 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:3038407-3039356 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:3043721-3044222 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:3045542-3046514 Neighboring gene glycine rich extracellular protein 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:3048182-3048682 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:3048683-3049183 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:3051481-3052017 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr16:3053764-3054722 Neighboring gene Sharpr-MPRA regulatory region 8596 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:3057599-3058558 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:3058559-3059516 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:3061783-3062608 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:3064184-3064351 Neighboring gene claudin 9

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Knockdown of PKMYT1 is associated with autophagy inhibition and apoptosis induction and suppresses tumor progression in hepatocellular carcinoma. Wu F, et al. Biochem Biophys Res Commun, 2023 Jan 15. PMID 36512849
  2. PKMYT1 inhibits lung adenocarcinoma progression by abrogating AKT1 activity. Wang S, et al. Cell Oncol (Dordr), 2023 Feb. PMID 36350496
  3. PKMYT1, exacerbating the progression of clear cell renal cell carcinoma, is implied as a biomarker for the diagnosis and prognosis. Chen J, et al. Aging (Albany NY), 2021 Dec 27. PMID 34959223, Free PMC Article
  4. Overexpression of PKMYT1 Facilitates Tumor Development and Is Correlated with Poor Prognosis in Clear Cell Renal Cell Carcinoma. Chen P, et al. Med Sci Monit, 2020 Oct 7. PMID 33024069, Free PMC Article
  5. PKMYT1 is associated with prostate cancer malignancy and may serve as a therapeutic target. Wang J, et al. Gene, 2020 Jun 20. PMID 32234541

See all (71) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PKMYT1 Promotes Epithelial-Mesenchymal Transition Process in Triple-Negative Breast Cancer by Activating Notch Signaling.
    Title: PKMYT1 Promotes Epithelial-Mesenchymal Transition Process in Triple-Negative Breast Cancer by Activating Notch Signaling.
  2. PKMYT1: A Potential Target for CCNE1 Amplificated Colorectal Tumors.
    Title: PKMYT1: A Potential Target for CCNE1 Amplificated Colorectal Tumors.
  3. ELF3 promotes gemcitabine resistance through PKMYT1/CDK1 signaling pathway in gallbladder cancer.
    Title: ELF3 promotes gemcitabine resistance through PKMYT1/CDK1 signaling pathway in gallbladder cancer.
  4. PKMYT1 inhibits lung adenocarcinoma progression by abrogating AKT1 activity.
    Title: PKMYT1 inhibits lung adenocarcinoma progression by abrogating AKT1 activity.
  5. Knockdown of PKMYT1 is associated with autophagy inhibition and apoptosis induction and suppresses tumor progression in hepatocellular carcinoma.
    Title: Knockdown of PKMYT1 is associated with autophagy inhibition and apoptosis induction and suppresses tumor progression in hepatocellular carcinoma.
  6. KDM2B mediates the Wnt/beta-catenin pathway through transcriptional activation of PKMYT1 via microRNA-let-7b-5p/EZH2 to affect the development of non-small cell lung cancer.
    Title: KDM2B mediates the Wnt/β-catenin pathway through transcriptional activation of PKMYT1 via microRNA-let-7b-5p/EZH2 to affect the development of non-small cell lung cancer.
  7. CCNE1 amplification is synthetic lethal with PKMYT1 kinase inhibition.
    Title: CCNE1 amplification is synthetic lethal with PKMYT1 kinase inhibition.
  8. Demethylase ALKBH5 suppresses invasion of gastric cancer via PKMYT1 m6A modification.
    Title: Demethylase ALKBH5 suppresses invasion of gastric cancer via PKMYT1 m6A modification.
  9. LncRNA PKMYT1AR promotes cancer stem cell maintenance in non-small cell lung cancer via activating Wnt signaling pathway.
    Title: LncRNA PKMYT1AR promotes cancer stem cell maintenance in non-small cell lung cancer via activating Wnt signaling pathway.
  10. PKMYT1, exacerbating the progression of clear cell renal cell carcinoma, is implied as a biomarker for the diagnosis and prognosis.
    Title: PKMYT1, exacerbating the progression of clear cell renal cell carcinoma, is implied as a biomarker for the diagnosis and prognosis.
Submit: New GeneRIF Correction See all GeneRIFs (24)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A genome-wide association study of the metabolic syndrome in Indian Asian men.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ20093, DKFZp547K1610

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein serine/threonine kinase activity TAS
Traceable Author Statement
more info
  
Process Evidence Code Pubs
involved_in G2/M transition of mitotic cell cycle TAS
Traceable Author Statement
more info
  
involved_in meiotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic cell cycle TAS
Traceable Author Statement
more info
 PubMed 
involved_in negative regulation of G2/M transition of mitotic cell cycle IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of G2/MI transition of meiotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of cyclin-dependent protein serine/threonine kinase activity TAS
Traceable Author Statement
more info
 PubMed 
involved_in regulation of mitotic nuclear division TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
  
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in endoplasmic reticulum TAS
Traceable Author Statement
more info
 PubMed 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane HDA PubMed 
located_in nucleolus IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase
Names
myt1 kinase
protein phosphatase 1, regulatory subunit 126
NP_001245379.1
NP_001245380.1
NP_004194.3
NP_872629.1
XP_011521036.1
XP_011521037.1
XP_024306258.1
XP_047290824.1
XP_047290825.1
XP_047290826.1
XP_047290827.1
XP_047290828.1
XP_047290829.1
XP_047290830.1
XP_054170295.1
XP_054170296.1
XP_054170297.1
XP_054170298.1
XP_054170299.1
XP_054170300.1
XP_054170301.1
XP_054170302.1
XP_054170303.1
XP_054170304.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001258450.2 → NP_001245379.1  membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase isoform 3

    See identical proteins and their annotated locations for NP_001245379.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in the 5' coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
    Source sequence(s)
    AK301926, BQ017689, DB111506
    Consensus CDS
    CCDS58415.1
    UniProtKB/TrEMBL
    Q0IJ49
    Related
    ENSP00000460868.1, ENST00000574730.5
    Conserved Domains (2) summary
    smart00220
    Location:41 → 288
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14050
    Location:39 → 288
    PKc_Myt1; Catalytic domain of the Dual-specificity protein kinase, Myt1

  2. NM_001258451.2 → NP_001245380.1  membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase isoform 4

    See identical proteins and their annotated locations for NP_001245380.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream, in-frame start codon, compared to variant 1. The encoded isoform (4) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AK097642, AK301926, BQ017689, DB111506
    Consensus CDS
    CCDS58414.1
    UniProtKB/TrEMBL
    Q0IJ49
    Related
    ENSP00000458943.1, ENST00000574385.5
    Conserved Domains (2) summary
    smart00220
    Location:101 → 348
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14050
    Location:99 → 348
    PKc_Myt1; Catalytic domain of the Dual-specificity protein kinase, Myt1

  3. NM_004203.5 → NP_004194.3  membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase isoform 1

    See identical proteins and their annotated locations for NP_004194.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    BC121161, BQ017689, DB009060
    Consensus CDS
    CCDS10486.1
    UniProtKB/Swiss-Prot
    B3KUN8, B4DXD4, D3DUA4, F8W164, I3L1V2, O14731, Q7LE24, Q8TCM9, Q99640
    UniProtKB/TrEMBL
    Q0IJ49
    Related
    ENSP00000262300.8, ENST00000262300.13
    Conserved Domains (1) summary
    cd14050
    Location:108 → 357
    PKc_Myt1; Catalytic domain of the Dual-specificity protein kinase, Myt1

  4. NM_182687.3 → NP_872629.1  membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase isoform 2

    See identical proteins and their annotated locations for NP_872629.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AK098452, BQ017689, DB009060
    Consensus CDS
    CCDS45391.1
    UniProtKB/TrEMBL
    A6NHV6, B4DG26
    Related
    ENSP00000397739.2, ENST00000440027.6
    Conserved Domains (2) summary
    smart00220
    Location:110 → 357
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14050
    Location:108 → 357
    PKc_Myt1; Catalytic domain of the Dual-specificity protein kinase, Myt1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    2972808..2980446 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011522735.4 → XP_011521037.1  membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase isoform X3

    See identical proteins and their annotated locations for XP_011521037.1

    UniProtKB/TrEMBL
    Q0IJ49
    Related
    ENSP00000459123.1, ENST00000573944.5
    Conserved Domains (2) summary
    smart00220
    Location:101 → 348
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14050
    Location:99 → 348
    PKc_Myt1; Catalytic domain of the Dual-specificity protein kinase, Myt1

  2. XM_047434868.1 → XP_047290824.1  membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase isoform X1

  3. XM_011522734.4 → XP_011521036.1  membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase isoform X2

    See identical proteins and their annotated locations for XP_011521036.1

    UniProtKB/Swiss-Prot
    B3KUN8, B4DXD4, D3DUA4, F8W164, I3L1V2, O14731, Q7LE24, Q8TCM9, Q99640
    UniProtKB/TrEMBL
    Q0IJ49
    Conserved Domains (1) summary
    cd14050
    Location:108 → 357
    PKc_Myt1; Catalytic domain of the Dual-specificity protein kinase, Myt1

  4. XM_047434869.1 → XP_047290825.1  membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase isoform X1

  5. XM_047434873.1 → XP_047290829.1  membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase isoform X2

    UniProtKB/Swiss-Prot
    B3KUN8, B4DXD4, D3DUA4, F8W164, I3L1V2, O14731, Q7LE24, Q8TCM9, Q99640

  6. XM_047434871.1 → XP_047290827.1  membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase isoform X1

  7. XM_047434874.1 → XP_047290830.1  membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase isoform X2

    UniProtKB/Swiss-Prot
    B3KUN8, B4DXD4, D3DUA4, F8W164, I3L1V2, O14731, Q7LE24, Q8TCM9, Q99640

  8. XM_047434872.1 → XP_047290828.1  membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase isoform X1

  9. XM_024450490.2 → XP_024306258.1  membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase isoform X2

    UniProtKB/Swiss-Prot
    B3KUN8, B4DXD4, D3DUA4, F8W164, I3L1V2, O14731, Q7LE24, Q8TCM9, Q99640
    UniProtKB/TrEMBL
    Q0IJ49
    Conserved Domains (1) summary
    cd14050
    Location:108 → 357
    PKc_Myt1; Catalytic domain of the Dual-specificity protein kinase, Myt1

  10. XM_047434870.1 → XP_047290826.1  membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    2999487..3007174 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054314328.1 → XP_054170303.1  membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase isoform X2

    UniProtKB/Swiss-Prot
    B3KUN8, B4DXD4, D3DUA4, F8W164, I3L1V2, O14731, Q7LE24, Q8TCM9, Q99640

  2. XM_054314322.1 → XP_054170297.1  membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase isoform X1

  3. XM_054314329.1 → XP_054170304.1  membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase isoform X3

  4. XM_054314320.1 → XP_054170295.1  membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase isoform X1

  5. XM_054314325.1 → XP_054170300.1  membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase isoform X2

    UniProtKB/Swiss-Prot
    B3KUN8, B4DXD4, D3DUA4, F8W164, I3L1V2, O14731, Q7LE24, Q8TCM9, Q99640

  6. XM_054314321.1 → XP_054170296.1  membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase isoform X1

  7. XM_054314326.1 → XP_054170301.1  membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase isoform X2

    UniProtKB/Swiss-Prot
    B3KUN8, B4DXD4, D3DUA4, F8W164, I3L1V2, O14731, Q7LE24, Q8TCM9, Q99640

  8. XM_054314323.1 → XP_054170298.1  membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase isoform X1

  9. XM_054314327.1 → XP_054170302.1  membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase isoform X2

    UniProtKB/Swiss-Prot
    B3KUN8, B4DXD4, D3DUA4, F8W164, I3L1V2, O14731, Q7LE24, Q8TCM9, Q99640

  10. XM_054314324.1 → XP_054170299.1  membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99640.1 GenPept UniProtKB/Swiss-Prot:Q99640

Gene LinkOut

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