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ZNF697 zinc finger protein 697 [ Homo sapiens (human) ]

Gene ID: 90874, updated on 2-Nov-2024

Summary

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Official Symbol
ZNF697provided by HGNC
Official Full Name
zinc finger protein 697provided by HGNC
Primary source
HGNC:HGNC:32034
See related
Ensembl:ENSG00000143067 MIM:620981; AllianceGenome:HGNC:32034
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZFP697
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in kidney (RPKM 3.1), placenta (RPKM 2.6) and 25 other tissues See more
Orthologs
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Genomic context

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See ZNF697 in Genome Data Viewer
Location:
1p12
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (119619377..119648266, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (119632580..119661937, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (120162000..120190889, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 622 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr1:120147336-120148535 Neighboring gene hydroxy-delta-5-steroid dehydrogenase, 3 beta, pseudogene 5 Neighboring gene MPRA-validated peak396 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1244 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1245 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1246 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:120190306-120190469 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1247 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr1:120190885-120191725 Neighboring gene uncharacterized LOC124904389 Neighboring gene Sharpr-MPRA regulatory region 8207 Neighboring gene uncharacterized LOC124904390 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1595

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Acetylation-Mimic Mutation of TRIM28-Lys304 to Gln Attenuates the Interaction with KRAB-Zinc-Finger Proteins and Affects Gene Expression in Leukemic K562 Cells. Chang YJ, et al. Int J Mol Sci, 2023 Jun 6. PMID 37372979, Free PMC Article
  2. Next-generation sequencing to generate interactome datasets. Yu H, et al. Nat Methods, 2011 Jun. PMID 21516116, Free PMC Article
  3. The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery. Kumar R, et al. Nat Commun, 2017 Nov 27. PMID 29180619, Free PMC Article
  4. Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains. Haenig C, et al. Cell Rep, 2020 Aug 18. PMID 32814053
  5. VIRMA mediates preferential m(6)A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. Yue Y, et al. Cell Discov, 2018. PMID 29507755, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC45731

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
zinc finger protein 697

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001080470.2 → NP_001073939.1  zinc finger protein 697

    See identical proteins and their annotated locations for NP_001073939.1

    Status: VALIDATED

    Source sequence(s)
    AL109966
    Consensus CDS
    CCDS44202.1
    UniProtKB/Swiss-Prot
    Q5TEC3, Q96IT2
    Related
    ENSP00000396857.2, ENST00000421812.3
    Conserved Domains (3) summary
    COG5048
    Location:364 → 545
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:439 → 459
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:480 → 504
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    119619377..119648266 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005271315.4 → XP_005271372.1  zinc finger protein 697 isoform X1

    See identical proteins and their annotated locations for XP_005271372.1

    UniProtKB/Swiss-Prot
    Q5TEC3, Q96IT2
    Conserved Domains (3) summary
    COG5048
    Location:364 → 545
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:439 → 459
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:480 → 504
    zf-H2C2_2; Zinc-finger double domain

  2. XM_047433849.1 → XP_047289805.1  zinc finger protein 697 isoform X1

    UniProtKB/Swiss-Prot
    Q5TEC3, Q96IT2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    119632580..119661937 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054339533.1 → XP_054195508.1  zinc finger protein 697 isoform X1

    UniProtKB/Swiss-Prot
    Q5TEC3, Q96IT2

  2. XM_054339534.1 → XP_054195509.1  zinc finger protein 697 isoform X1

    UniProtKB/Swiss-Prot
    Q5TEC3, Q96IT2

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_138366.1: Suppressed sequence

    Description
    NM_138366.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5TEC3.2 GenPept UniProtKB/Swiss-Prot:Q5TEC3

Gene LinkOut

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