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TCEAL8 transcription elongation factor A like 8 [ Homo sapiens (human) ]

Gene ID: 90843, updated on 5-Mar-2024

Summary

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Official Symbol
TCEAL8provided by HGNC
Official Full Name
transcription elongation factor A like 8provided by HGNC
Primary source
HGNC:HGNC:28683
See related
Ensembl:ENSG00000180964 AllianceGenome:HGNC:28683
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
WEX3
Summary
This gene encodes a member of the transcription elongation factor A (SII)-like (TCEAL) gene family. Members of this family contain TFA domains and may function as nuclear phosphoproteins that modulate transcription in a promoter context-dependent manner. Multiple family members are located on the X chromosome. Alternative splicing results in multiple transcript variants encoding a single isoform. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in thyroid (RPKM 33.7), urinary bladder (RPKM 29.7) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
Xq22.1
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (103252995..103255155, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (101699973..101702133, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (102507923..102510083, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene ribosomal protein SA pseudogene 59 Neighboring gene CRISPRi-validated cis-regulatory element chrX.1663 Neighboring gene brain expressed X-linked 4 Neighboring gene CRISPRi-validated cis-regulatory element chrX.1665 Neighboring gene CRISPRi-validated cis-regulatory element chrX.1666 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29816 Neighboring gene guanosine monophosphate reductase pseudogene Neighboring gene transcription elongation factor A like 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Genomic structure and chromosomal localization of TCEAL1, a human gene encoding the nuclear phosphoprotein p21/SIIR. Pillutla RC, et al. Genomics, 1999 Mar 1. PMID 10051408
  2. Mammalian BEX, WEX and GASP genes: coding and non-coding chimaerism sustained by gene conversion events. Winter EE, et al. BMC Evol Biol, 2005 Oct 12. PMID 16221301, Free PMC Article
  3. Protein interaction data set highlighted with human Ras-MAPK/PI3K signaling pathways. Wang J, et al. J Proteome Res, 2008 Sep. PMID 18624398
  4. The DNA sequence of the human X chromosome. Ross MT, et al. Nature, 2005 Mar 17. PMID 15772651, Free PMC Article
  5. Ubiquitin-mediated proteolysis of HuR by heat shock. Abdelmohsen K, et al. EMBO J, 2009 May 6. PMID 19322201, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Characterizes TCEAL1, another member of the human TCEAL gene family.
    Title: Genomic structure and chromosomal localization of TCEAL1, a human gene encoding the nuclear phosphoprotein p21/SIIR.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC45400

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
transcription elongation factor A protein-like 8
Names
TCEA-like protein 8
transcription elongation factor A (SII)-like 8
transcription elongation factor S-II protein-like 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016256.1 RefSeqGene

    Range
    5039..7199
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001006684.2 → NP_001006685.1  transcription elongation factor A protein-like 8

    See identical proteins and their annotated locations for NP_001006685.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same isoform.
    Source sequence(s)
    AK026349, BC035573, BU932815
    Consensus CDS
    CCDS14504.1
    UniProtKB/Swiss-Prot
    Q8IYN2
    Related
    ENSP00000353093.4, ENST00000360000.8
    Conserved Domains (1) summary
    pfam04538
    Location:1 → 113
    BEX; Brain expressed X-linked like family

  2. NM_153333.3 → NP_699164.1  transcription elongation factor A protein-like 8

    See identical proteins and their annotated locations for NP_699164.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same isoform.
    Source sequence(s)
    AK026349, BC035573, BU932815
    Consensus CDS
    CCDS14504.1
    UniProtKB/Swiss-Prot
    Q8IYN2
    Related
    ENSP00000361770.3, ENST00000372685.8
    Conserved Domains (1) summary
    pfam04538
    Location:1 → 113
    BEX; Brain expressed X-linked like family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    103252995..103255155 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    101699973..101702133 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8IYN2.1 GenPept UniProtKB/Swiss-Prot:Q8IYN2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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