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ZNF479 zinc finger protein 479 [ Homo sapiens (human) ]

Gene ID: 90827, updated on 5-Mar-2024

Summary

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Official Symbol
ZNF479provided by HGNC
Official Full Name
zinc finger protein 479provided by HGNC
Primary source
HGNC:HGNC:23258
See related
Ensembl:ENSG00000185177 MIM:617444; AllianceGenome:HGNC:23258
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KR19; HKr19
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription, DNA-templated. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward testis (RPKM 1.5) See more
Orthologs
all
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Genomic context

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Location:
7p11.2
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (57117676..57139864, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (57360976..57383153, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (57185383..57207571, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene septin 7 pseudogene 15 Neighboring gene gem-associated protein 7-like Neighboring gene GPCPD1 pseudogene 1 Neighboring gene vomeronasal 1 receptor 27 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Knockdown of ZNF479 inhibits proliferation and glycolysis of gastric cancer cells through regulating β-catenin/c-Myc signaling pathway. Jin XS, et al. Kaohsiung J Med Sci, 2021 Sep. PMID 34042257
  2. ZNF479 downregulates metallothionein-1 expression by regulating ASH2L and DNMT1 in hepatocellular carcinoma. Wu YJ, et al. Cell Death Dis, 2019 May 28. PMID 31138789, Free PMC Article
  3. Molecular cloning and preliminary functional analysis of two novel human KRAB zinc finger proteins, HKr18 and HKr19. Mark C, et al. DNA Cell Biol, 2001 May. PMID 11410164
  4. Interactome of the negative regulator of nuclear import BRCA1-binding protein 2. Fatima S, et al. Sci Rep, 2015 Mar 30. PMID 25820252, Free PMC Article
  5. A reference map of the human binary protein interactome. Luck K, et al. Nature, 2020 Apr. PMID 32296183, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Knockdown of ZNF479 inhibits proliferation and glycolysis of gastric cancer cells through regulating beta-catenin/c-Myc signaling pathway.
    Title: Knockdown of ZNF479 inhibits proliferation and glycolysis of gastric cancer cells through regulating β-catenin/c-Myc signaling pathway.
  2. ZNF479 regulates metallothionein-1 expression by modulating ASH2L in hepatocellular carcinoma.
    Title: ZNF479 downregulates metallothionein-1 expression by regulating ASH2L and DNMT1 in hepatocellular carcinoma.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
zinc finger protein 479
Names
KRAB zinc finger protein KR19
zinc finger protein Kr19

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001370129.2 → NP_001357058.1  zinc finger protein 479

    Status: VALIDATED

    Source sequence(s)
    AC099654, AC122133, AC125231
    Consensus CDS
    CCDS43590.1
    UniProtKB/Swiss-Prot
    Q96JC4
    Related
    ENSP00000324518.6, ENST00000319636.10
    Conserved Domains (4) summary
    smart00349
    Location:16 → 76
    KRAB; krueppel associated box
    COG5048
    Location:170 → 372
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:243 → 263
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:480 → 503
    zf-H2C2_2; Zinc-finger double domain

  2. NM_033273.3 → NP_150376.1  zinc finger protein 479

    See identical proteins and their annotated locations for NP_150376.1

    Status: VALIDATED

    Source sequence(s)
    AC099654, AC122133, AC125231
    Consensus CDS
    CCDS43590.1
    UniProtKB/Swiss-Prot
    Q96JC4
    Related
    ENSP00000333776.4, ENST00000331162.8
    Conserved Domains (4) summary
    smart00349
    Location:16 → 76
    KRAB; krueppel associated box
    COG5048
    Location:170 → 372
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:243 → 263
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:480 → 503
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    57117676..57139864 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011515604.4 → XP_011513906.2  zinc finger protein 479 isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    57360976..57383153 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054359305.1 → XP_054215280.1  zinc finger protein 479 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96JC4.1 GenPept UniProtKB/Swiss-Prot:Q96JC4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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