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ANGEL2 angel homolog 2 [ Homo sapiens (human) ]

Gene ID: 90806, updated on 2-Nov-2024

Summary

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Official Symbol
ANGEL2provided by HGNC
Official Full Name
angel homolog 2provided by HGNC
Primary source
HGNC:HGNC:30534
See related
Ensembl:ENSG00000174606 MIM:619001; AllianceGenome:HGNC:30534
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Ccr4d; KIAA0759L
Summary
Enables mRNA 3'-UTR binding activity. Involved in 3'-UTR-mediated mRNA stabilization and negative regulation of mitotic cell cycle. Located in Cajal body and cytoplasm. Is active in mitochondrial matrix. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in brain (RPKM 5.6), lymph node (RPKM 5.1) and 25 other tissues See more
Orthologs
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Genomic context

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See ANGEL2 in Genome Data Viewer
Location:
1q32.3
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (212992182..213015867, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (212235291..212258971, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (213165524..213189209, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124904507 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:213090085-213090684 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:213093647-213094446 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:213101650-213102592 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:213102593-213103534 Neighboring gene MPRA-validated peak689 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2520 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2521 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2522 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:213131647-213132304 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:213132964-213133621 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:213133682-213134182 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:213141040-213141685 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2524 Neighboring gene Sharpr-MPRA regulatory region 1741 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2525 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2526 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:213188046-213188634 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:213188635-213189222 Neighboring gene CRISPRi-validated cis-regulatory element chr1.11646 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1809 Neighboring gene vasohibin 2 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:213231113-213231272 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2528 Neighboring gene ribosomal protein S6 kinase C1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:213325631-213326306 Neighboring gene NANOG hESC enhancer GRCh37_chr1:213349583-213350260 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:213393895-213394085 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr1:213404976-213405900 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2529 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:213454938-213455452 Neighboring gene VISTA enhancer hs1324 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:213545088-213545614 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:213545615-213546139 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:213572574-213573110 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:213573111-213573646 Neighboring gene MPRA-validated peak692 silencer Neighboring gene VISTA enhancer hs204 Neighboring gene ribosomal protein L31 pseudogene 13 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr1:213680906-213681904 Neighboring gene NANOG hESC enhancer GRCh37_chr1:213685550-213686112 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_3904 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr1:213843687-213844216 Neighboring gene PROX1 antisense RNA 1 Neighboring gene long intergenic non-protein coding RNA 538

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. ANGEL2 is a member of the CCR4 family of deadenylases with 2',3'-cyclic phosphatase activity. Pinto PH, et al. Science, 2020 Jul 31. PMID 32732418
  2. Genomic structure and evolutionary context of the human feline leukemia virus subgroup C receptor (hFLVCR) gene: evidence for block duplications and de novo gene formation within duplicons of the hFLVCR locus. Lipovich L, et al. Gene, 2002 Mar 20. PMID 11943475
  3. An unconventional human Ccr4-Caf1 deadenylase complex in nuclear cajal bodies. Wagner E, et al. Mol Cell Biol, 2007 Mar. PMID 17178830, Free PMC Article
  4. RNA processing and modification protein, carbon catabolite repression 4 (Ccr4), arrests the cell cycle through p21-dependent and p53-independent pathway. Yi X, et al. J Biol Chem, 2012 Jun 15. PMID 22547059, Free PMC Article
  5. ANGEL2 phosphatase activity is required for non-canonical mitochondrial RNA processing. Clemente P, et al. Nat Commun, 2022 Sep 30. PMID 36180430, Free PMC Article

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ANGEL2 is a member of the CCR4 family of deadenylases with 2',3'-cyclic phosphatase activity.
    Title: ANGEL2 is a member of the CCR4 family of deadenylases with 2',3'-cyclic phosphatase activity.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ12793

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables mRNA 3'-UTR binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables mRNA 3'-UTR binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in 3'-UTR-mediated mRNA stabilization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in 3'-UTR-mediated mRNA stabilization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitochondrial mRNA 3'-end processing IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in Cajal body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in mitochondrial matrix IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion HTP PubMed 

General protein information

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Preferred Names
protein angel homolog 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001300753.2 → NP_001287682.1  protein angel homolog 2 isoform b

    See identical proteins and their annotated locations for NP_001287682.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (b) has a distinct N-terminus and is shorter than isoform a. Variants 2 and 3 encode the same isoform (b).
    Source sequence(s)
    AF510741, AI658922, AK022855, AK294479, BX103687, DC395916
    UniProtKB/TrEMBL
    B7Z297
    Conserved Domains (1) summary
    cl00490
    Location:43 → 416
    EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily

  2. NM_001300755.2 → NP_001287684.1  protein angel homolog 2 isoform b

    See identical proteins and their annotated locations for NP_001287684.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (b) has a distinct N-terminus and is shorter than isoform a. Variants 2 and 3 encode the same isoform (b).
    Source sequence(s)
    AF510741, AI658922, AK022855, AK299208, BX103687, DA718585
    UniProtKB/TrEMBL
    B7Z297
    Conserved Domains (1) summary
    cl00490
    Location:43 → 416
    EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily

  3. NM_001300757.2 → NP_001287686.1  protein angel homolog 2 isoform c

    See identical proteins and their annotated locations for NP_001287686.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (c) has a shorter N-terminus than isoform a. Variants 4 and 5 encode the same isoform (c).
    Source sequence(s)
    AF510741, AI658922, AK022855, BX103687, DC395916
    Consensus CDS
    CCDS73027.1
    UniProtKB/TrEMBL
    B7Z5N3
    Related
    ENSP00000438141.2, ENST00000535388.2
    Conserved Domains (1) summary
    cl00490
    Location:1 → 373
    EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily

  4. NM_001300758.2 → NP_001287687.1  protein angel homolog 2 isoform c

    See identical proteins and their annotated locations for NP_001287687.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks a portion of the 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (c) has a shorter N-terminus than isoform a. Variants 4 and 5 encode the same isoform (c).
    Source sequence(s)
    AI658922, AK022855, AL079275, BC047469, BX103687, DC395916
    Consensus CDS
    CCDS73027.1
    UniProtKB/TrEMBL
    B7Z5N3
    Related
    ENSP00000353696.2, ENST00000360506.6
    Conserved Domains (1) summary
    cl00490
    Location:1 → 373
    EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily

  5. NM_144567.5 → NP_653168.2  protein angel homolog 2 isoform a

    See identical proteins and their annotated locations for NP_653168.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AF510741, AI658922, AK022855, AL079275, BC016966, BC047469, BX103687, DC395916
    Consensus CDS
    CCDS1512.1
    UniProtKB/Swiss-Prot
    B7Z2U4, D3DTA3, Q5VTE6, Q86X13, Q8NHH3
    Related
    ENSP00000355929.3, ENST00000366962.8
    Conserved Domains (1) summary
    cl00490
    Location:169 → 542
    EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily

RNA

  1. NR_125333.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) lacks two internal exons, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AF510741, AI658922, AK022855, AK299365, BX103687, DC395916

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    212992182..213015867 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017002774.2 → XP_016858263.1  protein angel homolog 2 isoform X1

    Conserved Domains (1) summary
    cl00490
    Location:147 → 520
    EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily

  2. XM_005273346.3 → XP_005273403.1  protein angel homolog 2 isoform X1

    See identical proteins and their annotated locations for XP_005273403.1

    Conserved Domains (1) summary
    cl00490
    Location:147 → 520
    EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily

  3. XM_005273347.4 → XP_005273404.1  protein angel homolog 2 isoform X2

    See identical proteins and their annotated locations for XP_005273404.1

    UniProtKB/TrEMBL
    B7Z297
    Conserved Domains (1) summary
    cl00490
    Location:90 → 463
    EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily

  4. XM_005273344.2 → XP_005273401.1  protein angel homolog 2 isoform X1

    See identical proteins and their annotated locations for XP_005273401.1

    Conserved Domains (1) summary
    cl00490
    Location:147 → 520
    EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily

  5. XM_005273345.2 → XP_005273402.1  protein angel homolog 2 isoform X1

    See identical proteins and their annotated locations for XP_005273402.1

    Conserved Domains (1) summary
    cl00490
    Location:147 → 520
    EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily

  6. XM_047433784.1 → XP_047289740.1  protein angel homolog 2 isoform X3

  7. XM_047433785.1 → XP_047289741.1  protein angel homolog 2 isoform X4

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    212235291..212258971 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054339520.1 → XP_054195495.1  protein angel homolog 2 isoform X1

  2. XM_054339519.1 → XP_054195494.1  protein angel homolog 2 isoform X1

  3. XM_054339522.1 → XP_054195497.1  protein angel homolog 2 isoform X2

  4. XM_054339525.1 → XP_054195500.1  protein angel homolog 2 isoform X1

  5. XM_054339521.1 → XP_054195496.1  protein angel homolog 2 isoform X1

  6. XM_054339523.1 → XP_054195498.1  protein angel homolog 2 isoform X3

  7. XM_054339524.1 → XP_054195499.1  protein angel homolog 2 isoform X4

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5VTE6.1 GenPept UniProtKB/Swiss-Prot:Q5VTE6

Gene LinkOut

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