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DCAF15 DDB1 and CUL4 associated factor 15 [ Homo sapiens (human) ]

Gene ID: 90379, updated on 5-Mar-2024

Summary

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Official Symbol
DCAF15provided by HGNC
Official Full Name
DDB1 and CUL4 associated factor 15provided by HGNC
Primary source
HGNC:HGNC:25095
See related
Ensembl:ENSG00000132017 MIM:620109; AllianceGenome:HGNC:25095
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C19orf72
Summary
Enables small molecule binding activity. Involved in protein polyubiquitination and regulation of natural killer cell activation. Part of Cul4-RING E3 ubiquitin ligase complex. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis (RPKM 20.9), bone marrow (RPKM 11.3) and 24 other tissues See more
Orthologs
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Genomic context

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Location:
19p13.12
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (13952509..13961449)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (14078793..14087733)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (14063321..14072261)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:13993737-13994582 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:14000391-14000892 Neighboring gene break repair meiotic recombinase recruitment factor 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10218 Neighboring gene coiled-coil and C2 domain containing 1A Neighboring gene MPRA-validated peak3378 silencer Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:14046993-14047750 Neighboring gene podocan like 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14150 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10219 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:14069830-14070403 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:14070404-14070976 Neighboring gene regulatory factor X1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:14090312-14090838 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:14090839-14091365 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:14091366-14091891 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:14093768-14094294 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:14096053-14096944 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14151 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:14097836-14098726 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:14116358-14116886 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:14116887-14117414 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:14117415-14117942 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:14134324-14134824 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:14134825-14135325 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14152 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10222 Neighboring gene relaxin 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. In vivo target protein degradation induced by PROTACs based on E3 ligase DCAF15. Li L, et al. Signal Transduct Target Ther, 2020 Jul 27. PMID 32713946, Free PMC Article
  2. Tumor suppressor DCAF15 inhibits epithelial-mesenchymal transition by targeting ZEB1 for proteasomal degradation in hepatocellular carcinoma. Dong X, et al. Aging (Albany NY), 2021 Apr 4. PMID 33833131, Free PMC Article
  3. Targeting the E3 ubiquitin ligases DCAF15 and cereblon for cancer therapy. Nguyen KM, et al. Semin Cancer Biol, 2020 Dec. PMID 32200025
  4. Structural basis of indisulam-mediated RBM39 recruitment to DCAF15 E3 ligase complex. Bussiere DE, et al. Nat Chem Biol, 2020 Jan. PMID 31819272
  5. pSILAC method coupled with two complementary digestion approaches reveals PRPF39 as a new E7070-dependent DCAF15 substrate. Jia X, et al. J Proteomics, 2020 Jan 6. PMID 31626998

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. In vivo target protein degradation induced by PROTACs based on E3 ligase DCAF15.
    Title: In vivo target protein degradation induced by PROTACs based on E3 ligase DCAF15.
  2. Targeting the E3 ubiquitin ligases DCAF15 and cereblon for cancer therapy.
    Title: Targeting the E3 ubiquitin ligases DCAF15 and cereblon for cancer therapy.
  3. Tumor suppressor DCAF15 inhibits epithelial-mesenchymal transition by targeting ZEB1 for proteasomal degradation in hepatocellular carcinoma.
    Title: Tumor suppressor DCAF15 inhibits epithelial-mesenchymal transition by targeting ZEB1 for proteasomal degradation in hepatocellular carcinoma.
  4. aryl-sulfonamides neo-functionalize a shallow, non-conserved pocket on DCAF15 to selectively bind and degrade RBM39 and the closely related splicing factor RBM23 without the requirement for a high-affinity ligand
    Title: Structural complementarity facilitates E7820-mediated degradation of RBM39 by DCAF15.
  5. structural and mutational analysis of how indisulam mediates the DCAF15-RBM39 interaction
    Title: Structural basis of indisulam-mediated RBM39 recruitment to DCAF15 E3 ligase complex.
  6. DCAF15 expression may be a useful biomarker to guide clinical trials of splicing inhibitor sulfonamides(SPLAMs).
    Title: Anticancer sulfonamides target splicing by inducing RBM39 degradation via recruitment to DCAF15.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC99481

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables small molecule binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in immune system process IEA
Inferred from Electronic Annotation
more info
  
involved_in protein polyubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of natural killer cell activation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of Cul4-RING E3 ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Cul4-RING E3 ubiquitin ligase complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
DDB1- and CUL4-associated factor 15

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001393637.1 → NP_001380566.1  DDB1- and CUL4-associated factor 15 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC020916
    Conserved Domains (1) summary
    PHA03247
    Location:273 → 380
    PHA03247; large tegument protein UL36; Provisional

  2. NM_001393638.1 → NP_001380567.1  DDB1- and CUL4-associated factor 15 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC020916
    Conserved Domains (1) summary
    PHA03247
    Location:274 → 381
    PHA03247; large tegument protein UL36; Provisional

  3. NM_001393639.1 → NP_001380568.1  DDB1- and CUL4-associated factor 15 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC020916
    Conserved Domains (1) summary
    PHA03247
    Location:274 → 381
    PHA03247; large tegument protein UL36; Provisional

  4. NM_001393640.1 → NP_001380569.1  DDB1- and CUL4-associated factor 15 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC020916
    Conserved Domains (1) summary
    PHA03247
    Location:262 → 369
    PHA03247; large tegument protein UL36; Provisional

  5. NM_001393641.1 → NP_001380570.1  DDB1- and CUL4-associated factor 15 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC020916
    Conserved Domains (1) summary
    PHA03247
    Location:255 → 362
    PHA03247; large tegument protein UL36; Provisional

  6. NM_001393642.1 → NP_001380571.1  DDB1- and CUL4-associated factor 15 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC020916
    Conserved Domains (1) summary
    PHA03247
    Location:274 → 381
    PHA03247; large tegument protein UL36; Provisional

  7. NM_001393643.1 → NP_001380572.1  DDB1- and CUL4-associated factor 15 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC020916
    Conserved Domains (1) summary
    PHA03247
    Location:164 → 271
    PHA03247; large tegument protein UL36; Provisional

  8. NM_001393644.1 → NP_001380573.1  DDB1- and CUL4-associated factor 15 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC020916
    Conserved Domains (1) summary
    PHA03247
    Location:158 → 265
    PHA03247; large tegument protein UL36; Provisional

  9. NM_138353.4 → NP_612362.2  DDB1- and CUL4-associated factor 15 isoform 1

    See identical proteins and their annotated locations for NP_612362.2

    Status: VALIDATED

    Source sequence(s)
    AC020916
    Consensus CDS
    CCDS32926.1
    UniProtKB/Swiss-Prot
    B3KS86, Q66K64, Q96DW0, Q9BU31
    Related
    ENSP00000254337.5, ENST00000254337.11
    Conserved Domains (2) summary
    pfam14939
    Location:51 → 259
    DCAF15_WD40; DDB1-and CUL4-substrate receptor 15, WD repeat
    cl26464
    Location:274 → 381
    Atrophin-1; Atrophin-1 family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    13952509..13961449
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_021160022.1 Reference GRCh38.p14 PATCHES

    Range
    164350..173290
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    14078793..14087733
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q66K64.1 GenPept UniProtKB/Swiss-Prot:Q66K64

Gene LinkOut

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