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ZNF616 zinc finger protein 616 [ Homo sapiens (human) ]

Gene ID: 90317, updated on 5-Mar-2024

Summary

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Official Symbol
ZNF616provided by HGNC
Official Full Name
zinc finger protein 616provided by HGNC
Primary source
HGNC:HGNC:28062
See related
Ensembl:ENSG00000204611 AllianceGenome:HGNC:28062
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal (RPKM 3.2), ovary (RPKM 2.2) and 25 other tissues See more
Orthologs
all
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Genomic context

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Location:
19q13.41
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (52113091..52139938, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (55200303..55227149, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (52616344..52643191, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 432 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15035 Neighboring gene zinc finger protein 160 pseudogene Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr19:52568267-52569466 Neighboring gene zinc finger protein 841 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr19:52573383-52574582 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_51593 Neighboring gene uncharacterized LOC124904799 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15036 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10991 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10992 Neighboring gene ribosomal protein L37 pseudogene 23 Neighboring gene zinc finger protein 836 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15037

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Kelch Domain of Gigaxonin Interacts with Intermediate Filament Proteins Affected in Giant Axonal Neuropathy. Johnson-Kerner BL, et al. PLoS One, 2015. PMID 26460568, Free PMC Article
  2. ARHGAP24 represses β-catenin transactivation-induced invasiveness in hepatocellular carcinoma mainly by acting as a GTPase-independent scaffold. Yang W, et al. Theranostics, 2022. PMID 36168627, Free PMC Article
  3. SR protein kinases promote splicing of nonconsensus introns. Lipp JJ, et al. Nat Struct Mol Biol, 2015 Aug. PMID 26167880
  4. The involvement of Parkin-dependent mitophagy in the anti-cancer activity of Ginsenoside. Sun X, et al. J Ginseng Res, 2022 Mar. PMID 35509820, Free PMC Article
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. Hein MY, et al. Cell, 2015 Oct 22. PMID 26496610

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC45556, MGC149778

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 616

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_178523.5 → NP_848618.2  zinc finger protein 616

    See identical proteins and their annotated locations for NP_848618.2

    Status: VALIDATED

    Source sequence(s)
    AC011468, AK092266, BC032805, CD048470
    Consensus CDS
    CCDS33090.1
    UniProtKB/Swiss-Prot
    B3KRV1, Q08AN1, Q0P658, Q658V7
    Related
    ENSP00000471000.1, ENST00000600228.6
    Conserved Domains (5) summary
    smart00349
    Location:7 → 61
    KRAB; krueppel associated box
    COG5048
    Location:266 → 707
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:271 → 291
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:7 → 46
    KRAB; KRAB box
    pfam13465
    Location:620 → 644
    zf-H2C2_2; Zinc-finger double domain

RNA

  1. NR_135823.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC011468, AK092266, BC032805, BC125100, DA735752

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    52113091..52139938 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047439613.1 → XP_047295569.1  zinc finger protein 616 isoform X1

    UniProtKB/Swiss-Prot
    B3KRV1, Q08AN1, Q0P658, Q658V7

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    55200303..55227149 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054322515.1 → XP_054178490.1  zinc finger protein 616 isoform X1

    UniProtKB/Swiss-Prot
    B3KRV1, Q08AN1, Q0P658, Q658V7
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q08AN1.2 GenPept UniProtKB/Swiss-Prot:Q08AN1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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