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TP53I13 tumor protein p53 inducible protein 13 [ Homo sapiens (human) ]

Gene ID: 90313, updated on 5-Mar-2024

Summary

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Official Symbol
TP53I13provided by HGNC
Official Full Name
tumor protein p53 inducible protein 13provided by HGNC
Primary source
HGNC:HGNC:25102
See related
Ensembl:ENSG00000167543 AllianceGenome:HGNC:25102
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DSCP1
Summary
Involved in several processes, including negative regulation of cell cycle; response to UV; and response to xenobiotic stimulus. Located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in fat (RPKM 17.1), spleen (RPKM 12.9) and 25 other tissues See more
Orthologs
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Genomic context

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See TP53I13 in Genome Data Viewer
Location:
17q11.2
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (29566300..29582340)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (30510000..30525212)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (27895294..27900175)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene TAO kinase 1 Neighboring gene RNA, U6 small nuclear 1034, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11978 Neighboring gene MPRA-validated peak2781 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:27853602-27854102 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:27854103-27854603 Neighboring gene uncharacterized LOC124904148 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11979 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8373 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8374 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11980 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8375 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:27896259-27896759 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8376 Neighboring gene abhydrolase domain containing 15 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:27911138-27911952 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:27911953-27912765 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:27914948-27915847 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8377 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:27916747-27917646 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8379 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11982 Neighboring gene GIT ArfGAP 1 Neighboring gene ankyrin repeat domain 13B Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:27940429-27941292 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8382 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:27942158-27943021 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8384 Neighboring gene Sharpr-MPRA regulatory region 12866 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8385 Neighboring gene coronin 6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. DSCP1, a novel TP53-inducible gene, is upregulated by strong genotoxic stresses and its overexpression inhibits tumor cell growth in vitro. Hata T, et al. Int J Oncol, 2004 Mar. PMID 14767535
  2. Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. Otsuki T, et al. DNA Res, 2005. PMID 16303743
  3. A reference map of the human binary protein interactome. Luck K, et al. Nature, 2020 Apr. PMID 32296183, Free PMC Article
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. Ota T, et al. Nat Genet, 2004 Jan. PMID 14702039
  5. Architecture of the human interactome defines protein communities and disease networks. Huttlin EL, et al. Nature, 2017 May 25. PMID 28514442, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of cell cycle IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to UV IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to organic cyclic compound IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to xenobiotic stimulus IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
tumor protein p53-inducible protein 13
Names
damage-stimulated cytoplasmic protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001346077.1 → NP_001333006.1  tumor protein p53-inducible protein 13 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2 and 3 both encode isoform b.
    Source sequence(s)
    AC104564

  2. NM_001346078.1 → NP_001333007.1  tumor protein p53-inducible protein 13 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2 and 3 both encode isoform b.
    Source sequence(s)
    AC104564

  3. NM_001346079.2 → NP_001333008.1  tumor protein p53-inducible protein 13 isoform c precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (c) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    AC104564

  4. NM_001346081.2 → NP_001333010.1  tumor protein p53-inducible protein 13 isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks an alternate exon and uses an alternate splice junction compared to variant 1. The resulting isoform (d) is shorter at the N-terminus compared to isoform a. Variants 5 and 6 both encode the same isoform (d).
    Source sequence(s)
    AC104564

  5. NM_001346082.1 → NP_001333011.1  tumor protein p53-inducible protein 13 isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) has an alternate 5' end, lacks an alternate exon, and uses an alternate splice junction compared to variant 1. The resulting isoform (d) is shorter at the N-terminus compared to isoform a. Variants 5 and 6 both encode the same isoform (d).
    Source sequence(s)
    AC104564

  6. NM_138349.4 → NP_612358.3  tumor protein p53-inducible protein 13 isoform a precursor

    See identical proteins and their annotated locations for NP_612358.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AL551604, BC001593
    Consensus CDS
    CCDS42289.1
    UniProtKB/Swiss-Prot
    Q7L5U3, Q8NBR0
    Related
    ENSP00000301057.7, ENST00000301057.8

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    29566300..29582340
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047437003.1 → XP_047292959.1  tumor protein p53-inducible protein 13 isoform X2

  2. XM_047437000.1 → XP_047292956.1  tumor protein p53-inducible protein 13 isoform X2

  3. XM_047437001.1 → XP_047292957.1  tumor protein p53-inducible protein 13 isoform X2

  4. XM_047437002.1 → XP_047292958.1  tumor protein p53-inducible protein 13 isoform X2

  5. XM_047437005.1 → XP_047292961.1  tumor protein p53-inducible protein 13 isoform X2

  6. XM_047437004.1 → XP_047292960.1  tumor protein p53-inducible protein 13 isoform X2

  7. XM_047436999.1 → XP_047292955.1  tumor protein p53-inducible protein 13 isoform X1

  8. XM_047437006.1 → XP_047292962.1  tumor protein p53-inducible protein 13 isoform X3

  9. XM_047437007.1 → XP_047292963.1  tumor protein p53-inducible protein 13 isoform X4

  10. XM_047437008.1 → XP_047292964.1  tumor protein p53-inducible protein 13 isoform X5

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    30510000..30525212
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054317688.1 → XP_054173663.1  tumor protein p53-inducible protein 13 isoform X2

  2. XM_054317689.1 → XP_054173664.1  tumor protein p53-inducible protein 13 isoform X2

  3. XM_054317690.1 → XP_054173665.1  tumor protein p53-inducible protein 13 isoform X2

  4. XM_054317692.1 → XP_054173667.1  tumor protein p53-inducible protein 13 isoform X2

  5. XM_054317687.1 → XP_054173662.1  tumor protein p53-inducible protein 13 isoform X2

  6. XM_054317691.1 → XP_054173666.1  tumor protein p53-inducible protein 13 isoform X2

  7. XM_054317686.1 → XP_054173661.1  tumor protein p53-inducible protein 13 isoform X1

  8. XM_054317693.1 → XP_054173668.1  tumor protein p53-inducible protein 13 isoform X3

  9. XM_054317694.1 → XP_054173669.1  tumor protein p53-inducible protein 13 isoform X4

  10. XM_054317695.1 → XP_054173670.1  tumor protein p53-inducible protein 13 isoform X5

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8NBR0.1 GenPept UniProtKB/Swiss-Prot:Q8NBR0

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