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MIDN midnolin [ Homo sapiens (human) ]

Gene ID: 90007, updated on 7-Apr-2024

Summary

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Official Symbol
MIDNprovided by HGNC
Official Full Name
midnolinprovided by HGNC
Primary source
HGNC:HGNC:16298
See related
Ensembl:ENSG00000167470 MIM:606700; AllianceGenome:HGNC:16298
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Stx
Summary
Predicted to enable kinase binding activity. Predicted to be involved in negative regulation of glucokinase activity and negative regulation of insulin secretion. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bone marrow (RPKM 27.5), gall bladder (RPKM 18.8) and 25 other tissues See more
Orthologs
mouse all
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Genomic context

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Location:
19p13.3
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (1248583..1259143)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (1217106..1227667)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (1248582..1259142)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9673 Neighboring gene ATP synthase F1 subunit delta Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9674 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13600 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:1245978-1246723 Neighboring gene uncharacterized LOC102723811 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9675 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:1248659-1249192 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9677 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9678 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9679 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9680 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9681 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9682 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9683 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:1251037-1251976 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9685 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9686 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9687 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9688 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13601 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13602 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9689 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9690 Neighboring gene IQ motif and SEC7 domain-containing protein 2-like Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13603 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13604 Neighboring gene uncharacterized LOC105372236 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13605 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13606 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13607 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9691 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9692 Neighboring gene CIRBP antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9693 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9694 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9695 Neighboring gene cold inducible RNA binding protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Structural Variants of Midnolin, a Genetic Risk Factor for Parkinson's Disease, in a Yamagata Cohort. Sato H, et al. Biol Pharm Bull, 2023. PMID 36858566
  2. Midnolin is a confirmed genetic risk factor for Parkinson's disease. Obara Y, et al. Ann Clin Transl Neurol, 2019 Nov. PMID 31588691, Free PMC Article
  3. Novel nucleolar protein, midnolin, is expressed in the mesencephalon during mouse development. Tsukahara M, et al. Gene, 2000 Aug 22. PMID 10974535
  4. Midnolin is a novel regulator of parkin expression and is associated with Parkinson's Disease. Obara Y, et al. Sci Rep, 2017 Jul 19. PMID 28724963, Free PMC Article
  5. Identification of the ubiquitin-like domain of midnolin as a new glucokinase interaction partner. Hofmeister-Brix A, et al. J Biol Chem, 2013 Dec 13. PMID 24187134, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The midnolin-proteasome pathway catches proteins for ubiquitination-independent degradation.
    Title: The midnolin-proteasome pathway catches proteins for ubiquitination-independent degradation.
  2. Structural Variants of Midnolin, a Genetic Risk Factor for Parkinson's Disease, in a Yamagata Cohort.
    Title: Structural Variants of Midnolin, a Genetic Risk Factor for Parkinson's Disease, in a Yamagata Cohort.
  3. Midnolin is a confirmed genetic risk factor for Parkinson's disease.
    Title: Midnolin is a confirmed genetic risk factor for Parkinson's disease.
  4. MIDN promotes the expression of parkin E3 ubiquitin ligase, and that MIDN loss can trigger Parkinson's disease-related pathogenic mechanisms.
    Title: Midnolin is a novel regulator of parkin expression and is associated with Parkinson's Disease.
  5. midnolin plays a role in cellular signaling of adult tissues and regulates glucokinase enzyme activity in pancreatic beta cells
    Title: Identification of the ubiquitin-like domain of midnolin as a new glucokinase interaction partner.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • DKFZp547M072

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables kinase binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables molecular adaptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables molecular_function ND
No biological Data available
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in negative regulation of glucokinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in negative regulation of insulin secretion ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in proteasomal ubiquitin-independent protein catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
midnolin
Names
midbrain nucleolar protein
stuxnet homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001388306.1 → NP_001375235.1  midnolin isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC004221
    Consensus CDS
    CCDS92478.1
    UniProtKB/TrEMBL
    A0A804HKJ8
    Related
    ENSP00000507955.1, ENST00000682408.1
    Conserved Domains (1) summary
    cd01804
    Location:31 → 100
    Ubl_midnolin; ubiquitin-like (Ubl) domain found in midnolin and similar proteins

  2. NM_001388307.1 → NP_001375236.1  midnolin isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC004221
    Conserved Domains (1) summary
    cd01804
    Location:31 → 100
    Ubl_midnolin; ubiquitin-like (Ubl) domain found in midnolin and similar proteins

  3. NM_001388474.1 → NP_001375403.1  midnolin isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC004221
    Consensus CDS
    CCDS32864.1
    UniProtKB/Swiss-Prot
    Q504T8, Q96BW8
    Related
    ENSP00000467679.1, ENST00000591446.7
    Conserved Domains (1) summary
    cd01804
    Location:31 → 100
    Ubl_midnolin; ubiquitin-like (Ubl) domain found in midnolin and similar proteins

  4. NM_177401.5 → NP_796375.3  midnolin isoform 2

    See identical proteins and their annotated locations for NP_796375.3

    Status: VALIDATED

    Source sequence(s)
    AA421908, AL512725, BC015089, BC060848, BM966744
    Consensus CDS
    CCDS32864.1
    UniProtKB/Swiss-Prot
    Q504T8, Q96BW8
    Related
    ENSP00000300952.2, ENST00000300952.7
    Conserved Domains (1) summary
    cd01804
    Location:31 → 100
    Ubl_midnolin; ubiquitin-like (Ubl) domain found in midnolin and similar proteins

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    1248583..1259143
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005259672.4 → XP_005259729.1  midnolin isoform X1

    Conserved Domains (1) summary
    cd01804
    Location:31 → 100
    Ubl_midnolin; ubiquitin-like (Ubl) domain found in midnolin and similar proteins

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    1217106..1227667
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054322499.1 → XP_054178474.1  midnolin isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q504T8.2 GenPept UniProtKB/Swiss-Prot:Q504T8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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