ABCC10 ATP binding cassette subfamily C member 10 [Homo sapiens (human)] - Gene

Summary

Official Symbol: ABCC10provided by HGNC
Official Full Name: ATP binding cassette subfamily C member 10provided by HGNC
Primary source: HGNC:HGNC:52
See related: Ensembl:ENSG00000124574 MIM:612509; AllianceGenome:HGNC:52
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: MRP7; SIMRP7; EST182763
Summary: The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White). This ABC full-transporter is a member of the MRP subfamily which is involved in multi-drug resistance. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Nov 2010]
Expression: Ubiquitous expression in ovary (RPKM 3.1), spleen (RPKM 3.0) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 6p21.1

Exon count:: 27

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	6	NC_000006.12 (43427541..43451994)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	6	NC_060930.1 (43256321..43280761)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	6	NC_000006.11 (43395279..43418165)

Chromosome 6 - NC_000006.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ATP-Binding Cassette Transporter Family C Protein 10 Participates in the Synthesis and Efflux of Hexosylceramides in Liver Cells.
Title: ATP-Binding Cassette Transporter Family C Protein 10 Participates in the Synthesis and Efflux of Hexosylceramides in Liver Cells.
Exosomal Delivery of FTO Confers Gefitinib Resistance to Recipient Cells through ABCC10 Regulation in an m6A-dependent Manner.
Title: Exosomal Delivery of FTO Confers Gefitinib Resistance to Recipient Cells through ABCC10 Regulation in an m6A-dependent Manner.
In the cancer cell lines, only rs2125739 of ABCC10 gene was significantly associated with docetaxel cytotoxicity, and this was confirmed in the genome-edited cell line. In the non-small cell lung cancer (NSCLC) patients, there were no significant differences related to rs2125739 genotype in terms of response rate, progression free and overall survival. However, this SNP was associated with grade 3/4 neutropenia.
Title: Genetic variation in the ATP binding cassette transporter ABCC10 is associated with neutropenia for docetaxel in Japanese lung cancer patients cohort.
FOXM1 promotes 5-FU resistance by up-regulating ABCC10 expression in colorectal tumor cells.
Title: FOXM1 evokes 5-fluorouracil resistance in colorectal cancer depending on ABCC10.
It is thus inferred, that ABCC10 expression in CWR22Rv1 cells is not S phase-specific but is primarily associated with cell proliferation.
Title: E2F site in the essential promoter region does not confer S phase-specific transcription of the ABCC10 gene in human prostate cancer cells.
The present study shows that the protein expression of ABCC10 significantly associates with overall survival and the expression of ABCC11 with disease-free interval of colorectal cancer patients
Title: Protein expression of ATP-binding cassette transporters ABCC10 and ABCC11 associates with survival of colorectal cancer patients.
BAG3-mediated miRNA let-7g and let-7i inhibit proliferation and enhance apoptosis of human esophageal carcinoma cells by targeting the drug transporter ABCC10 and modulates cisplatin resistance.
Title: BAG3-mediated miRNA let-7g and let-7i inhibit proliferation and enhance apoptosis of human esophageal carcinoma cells by targeting the drug transporter ABCC10.
the combination of paclitaxel and masitinib could serve as a novel and useful therapeutic strategy to reverse paclitaxel resistance mediated by ABCC10
Title: Masitinib antagonizes ATP-binding cassette subfamily C member 10-mediated paclitaxel resistance: a preclinical study.
ABCC10 expression is correlated with human breast cancer subtype using breast tissue microarrays.
Title: Abcc10 status affects mammary tumour growth, metastasis, and docetaxel treatment response.
This study shows that ABCC10 confers resistance to the anticancer agents taxanes and vinca alkaloids in vitro.
Title: Analysis of the drug resistance profile of multidrug resistance protein 7 (ABCC10): resistance to docetaxel.

Submit: New GeneRIF Correction See all GeneRIFs (25)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

MARC_12101-12102:1004643664:1 (e-PCR)
- UniSTS:267339

MARC_12101-12102:1007735644:3 (e-PCR)
- UniSTS:267339

ABCC10_2608 (e-PCR)
- UniSTS:280420

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables ABC-type glutathione S-conjugate transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables ABC-type transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables ABC-type xenobiotic transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables ATPase-coupled inorganic anion transmembrane transporter activity	TAS Traceable Author Statement more info
enables ATPase-coupled transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in leukotriene metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in leukotriene transport	IDA Inferred from Direct Assay more info	PubMed
involved_in lipid transport	IEA Inferred from Electronic Annotation more info
involved_in monoatomic anion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in transmembrane transport	TAS Traceable Author Statement more info
involved_in xenobiotic transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in basal plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in basolateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in lysosomal membrane	HDA more info	PubMed
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: ATP-binding cassette sub-family C member 10

Names: ATP-binding cassette, sub-family C (CFTR/MRP), member 10; multidrug resistance-associated protein 7

NP_001185863.1

EC 7.6.2.2

EC 7.6.2.3

NP_001337447.1

EC 7.6.2.2

EC 7.6.2.3

NP_258261.2

EC 7.6.2.2

EC 7.6.2.3

XP_011513276.3

EC 7.6.2.2

EC 7.6.2.3

XP_011513287.1

EC 7.6.2.2

EC 7.6.2.3

XP_011513288.1

EC 7.6.2.2

EC 7.6.2.3

XP_047275450.1

EC 7.6.2.2

EC 7.6.2.3

XP_047275451.1

EC 7.6.2.2

EC 7.6.2.3

XP_047275452.1

EC 7.6.2.2

EC 7.6.2.3

XP_047275453.1

EC 7.6.2.2

EC 7.6.2.3

XP_047275454.1

EC 7.6.2.2

EC 7.6.2.3

XP_047275455.1

EC 7.6.2.2

EC 7.6.2.3

XP_047275456.1

EC 7.6.2.2

EC 7.6.2.3

XP_047275457.1

EC 7.6.2.2

EC 7.6.2.3

XP_047275458.1

EC 7.6.2.2

EC 7.6.2.3

XP_054212675.1

EC 7.6.2.2

EC 7.6.2.3

XP_054212676.1

EC 7.6.2.2

EC 7.6.2.3

XP_054212677.1

EC 7.6.2.2

EC 7.6.2.3

XP_054212678.1

EC 7.6.2.2

EC 7.6.2.3

XP_054212679.1

EC 7.6.2.2

EC 7.6.2.3

XP_054212680.1

EC 7.6.2.2

EC 7.6.2.3

XP_054212681.1

EC 7.6.2.2

EC 7.6.2.3

XP_054212682.1

EC 7.6.2.2

EC 7.6.2.3

XP_054212683.1

EC 7.6.2.2

EC 7.6.2.3

XP_054212684.1

EC 7.6.2.2

EC 7.6.2.3

XP_054212685.1

EC 7.6.2.2

EC 7.6.2.3

XP_054212686.1

EC 7.6.2.2

EC 7.6.2.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001198934.2 → NP_001185863.1 ATP-binding cassette sub-family C member 10 isoform MRP7

See identical proteins and their annotated locations for NP_001185863.1

Status: REVIEWED

Description

Transcript Variant: This variant (MRP7) encodes the longest isoform (MRP7).

Source sequence(s)

AK000002, AL359813, AY032599

Consensus CDS

CCDS56430.1

UniProtKB/Swiss-Prot

Q5T3U5, Q8NHX7, Q9H7N2, Q9NXY3, Q9UF48

Related

ENSP00000361608.4, ENST00000372530.9

Conserved Domains (4) summary

cd03244
Location:1244 → 1463

ABCC_MRP_domain2; ATP-binding cassette domain 2 of multidrug resistance-associated protein

cd03250
Location:598 → 801

ABCC_MRP_domain1; ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C

TIGR01271
Location:219 → 1469

CFTR_protein; cystic fibrosis transmembrane conductor regulator (CFTR)

cl00549
Location:289 → 551

ABC_membrane; ABC transporter transmembrane region
NM_001350518.2 → NP_001337447.1 ATP-binding cassette sub-family C member 10 isoform 3

Status: REVIEWED

Description

Transcript Variant: This variant (3) encodes isoform 3.

Source sequence(s)

AL359813

Conserved Domains (1) summary

cl26602
Location:8 → 1025

SunT; ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]
NM_033450.3 → NP_258261.2 ATP-binding cassette sub-family C member 10 isoform MRP7A

See identical proteins and their annotated locations for NP_258261.2

Status: REVIEWED

Description

Transcript Variant: This variant (MRP7A), also known as SIMRP7, has multiple differences, compared to variant MRP7. These differences result in a distinct 5' UTR and cause translation initiation at a downstream start codon, compared to variant MRP7. The encoded protein (isoform MRP7A) is shorter than isoform MRP7.

Source sequence(s)

AL359813

Consensus CDS

CCDS4896.1

UniProtKB/Swiss-Prot

Q5T3U5

Related

ENSP00000244533.3, ENST00000244533.7

Conserved Domains (4) summary

cd03244
Location:1216 → 1435

ABCC_MRP_domain2; ATP-binding cassette domain 2 of multidrug resistance-associated protein

cd03250
Location:570 → 773

ABCC_MRP_domain1; ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C

TIGR01271
Location:176 → 1441

CFTR_protein; cystic fibrosis transmembrane conductor regulator (CFTR)

cl00549
Location:246 → 508

ABC_membrane; ABC transporter transmembrane region

RNA

NR_146762.2 RNA Sequence

Status: REVIEWED

Source sequence(s)

AL359813

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000006.12 Reference GRCh38.p14 Primary Assembly

Range

43427541..43451994

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047419494.1 → XP_047275450.1 ATP-binding cassette sub-family C member 10 isoform X1
XM_047419495.1 → XP_047275451.1 ATP-binding cassette sub-family C member 10 isoform X2

UniProtKB/Swiss-Prot

Q5T3U5, Q8NHX7, Q9H7N2, Q9NXY3, Q9UF48
XM_047419496.1 → XP_047275452.1 ATP-binding cassette sub-family C member 10 isoform X6
XM_047419497.1 → XP_047275453.1 ATP-binding cassette sub-family C member 10 isoform X7
XM_011514974.4 → XP_011513276.3 ATP-binding cassette sub-family C member 10 isoform X2

UniProtKB/Swiss-Prot

Q5T3U5, Q8NHX7, Q9H7N2, Q9NXY3, Q9UF48
XM_047419499.1 → XP_047275455.1 ATP-binding cassette sub-family C member 10 isoform X3
XM_047419502.1 → XP_047275458.1 ATP-binding cassette sub-family C member 10 isoform X4
XM_047419498.1 → XP_047275454.1 ATP-binding cassette sub-family C member 10 isoform X8
XM_047419501.1 → XP_047275457.1 ATP-binding cassette sub-family C member 10 isoform X10
XM_047419500.1 → XP_047275456.1 ATP-binding cassette sub-family C member 10 isoform X9
XM_011514986.4 → XP_011513288.1 ATP-binding cassette sub-family C member 10 isoform X5

See identical proteins and their annotated locations for XP_011513288.1

Conserved Domains (4) summary

cd03244
Location:593 → 812

ABCC_MRP_domain2; ATP-binding cassette domain 2 of multidrug resistance-associated protein

cd03250
Location:2 → 150

ABCC_MRP_domain1; ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C

COG4987
Location:278 → 815

CydC; ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion, Posttranslational modification, protein turnover, chaperones]

cl00549
Location:308 → 540

ABC_membrane; ABC transporter transmembrane region
XM_011514985.4 → XP_011513287.1 ATP-binding cassette sub-family C member 10 isoform X5

See identical proteins and their annotated locations for XP_011513287.1

Conserved Domains (4) summary

cd03244
Location:593 → 812

ABCC_MRP_domain2; ATP-binding cassette domain 2 of multidrug resistance-associated protein

cd03250
Location:2 → 150

ABCC_MRP_domain1; ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C

COG4987
Location:278 → 815

CydC; ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion, Posttranslational modification, protein turnover, chaperones]

cl00549
Location:308 → 540

ABC_membrane; ABC transporter transmembrane region

RNA

XR_007059383.1 RNA Sequence
XR_007059384.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

NC_060930.1 Alternate T2T-CHM13v2.0

Range

43256321..43280761

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054356701.1 → XP_054212676.1 ATP-binding cassette sub-family C member 10 isoform X1
XM_054356702.1 → XP_054212677.1 ATP-binding cassette sub-family C member 10 isoform X2

UniProtKB/Swiss-Prot

Q5T3U5, Q8NHX7, Q9H7N2, Q9NXY3, Q9UF48
XM_054356707.1 → XP_054212682.1 ATP-binding cassette sub-family C member 10 isoform X15
XM_054356705.1 → XP_054212680.1 ATP-binding cassette sub-family C member 10 isoform X14
XM_054356708.1 → XP_054212683.1 ATP-binding cassette sub-family C member 10 isoform X16
XM_054356703.1 → XP_054212678.1 ATP-binding cassette sub-family C member 10 isoform X12
XM_054356704.1 → XP_054212679.1 ATP-binding cassette sub-family C member 10 isoform X13
XM_054356700.1 → XP_054212675.1 ATP-binding cassette sub-family C member 10 isoform X11
XM_054356709.1 → XP_054212684.1 ATP-binding cassette sub-family C member 10 isoform X4
XM_054356706.1 → XP_054212681.1 ATP-binding cassette sub-family C member 10 isoform X3
XM_054356711.1 → XP_054212686.1 ATP-binding cassette sub-family C member 10 isoform X5
XM_054356710.1 → XP_054212685.1 ATP-binding cassette sub-family C member 10 isoform X5