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Rpe65 retinoid isomerohydrolase RPE65 [ Rattus norvegicus (Norway rat) ]

Gene ID: 89826, updated on 28-Oct-2024

Summary

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Official Symbol
Rpe65provided by RGD
Official Full Name
retinoid isomerohydrolase RPE65provided by RGD
Primary source
RGD:621396
See related
EnsemblRapid:ENSRNOG00000009582 AllianceGenome:RGD:621396
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity. Involved in several processes, including circadian rhythm; neural retina development; and retinoid metabolic process. Located in cell body. Human ortholog(s) of this gene implicated in Leber congenital amaurosis 2; retinitis pigmentosa; retinitis pigmentosa 20; and retinitis pigmentosa 87. Orthologous to human RPE65 (retinoid isomerohydrolase RPE65). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Biased expression in Brain (RPKM 24.8) and Heart (RPKM 5.6) See more
Orthologs
human mouse all
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Genomic context

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See Rpe65 in Genome Data Viewer
Location:
2q45
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (251425228..251457209)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (248766497..248798403)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (266141581..266169197)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108350149 Neighboring gene DEP domain containing 1 Neighboring gene uncharacterized LOC102556878 Neighboring gene transfer RNA isoleucine (anticodon AAU) 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Distribution of retinol isomerase in vertebrate eyes and its emergence during retinal development. Bridges CD. Vision Res, 1989. PMID 2631392
  2. The visual cycle operates via an isomerase acting on all-trans retinol in the pigment epithelium. Bridges CD, et al. Science, 1987 Jun 26. PMID 3603006
  3. Increased light damage susceptibility at night does not correlate with RPE65 levels and rhodopsin regeneration in rats. Beatrice J, et al. Exp Eye Res, 2003 Jun. PMID 12742352
  4. Experimental autoimmune uveitis induced by immunization with retinal pigment epithelium-specific 65-kDa protein peptides. Nakamura H, et al. Curr Eye Res, 2005 Aug. PMID 16109648
  5. Expression of RPE65, a putative receptor for plasma retinol-binding protein, in nonmelanocytic skin tumours. Hinterhuber G, et al. Br J Dermatol, 2005 Oct. PMID 16181461

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The damaged retinal pigment epithelium showed earlier expression of PCNA and RPE65 than photoreceptor out segments
    Title: Ultrastructural Changes and Expression of PCNA and RPE65 in Sodium Iodate-Induced Acute Retinal Pigment Epithelium Degeneration Model.
  2. Alpha-phenyl-N-tert-butylnitrone (PBN) prevents light-induced degeneration of the retina by inhibiting RPE65 protein isomerohydrolase activity.
    Title: Alpha-phenyl-N-tert-butylnitrone (PBN) prevents light-induced degeneration of the retina by inhibiting RPE65 protein isomerohydrolase activity.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity ISO
Inferred from Sequence Orthology
more info
  
enables all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables all-trans-retinyl-palmitate hydrolase, 11-cis retinol forming activity ISO
Inferred from Sequence Orthology
more info
  
enables all-trans-retinyl-palmitate hydrolase, 11-cis retinol forming activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables beta-carotene 15,15'-dioxygenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cardiolipin binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables isomerase activity ISO
Inferred from Sequence Orthology
more info
  
enables isomerase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylcholine binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables phosphatidylserine binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables retinol isomerase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in camera-type eye development IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in circadian rhythm IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in detection of light stimulus involved in visual perception ISO
Inferred from Sequence Orthology
more info
  
involved_in neural retina development IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to light stimulus IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in retina homeostasis ISO
Inferred from Sequence Orthology
more info
  
involved_in retinal metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in retinal metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in retinoid metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in retinol metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in visual perception IEA
Inferred from Electronic Annotation
more info
  
involved_in zeaxanthin biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in zeaxanthin biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in zeaxanthin biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in cell body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
retinoid isomerohydrolase
Names
RPE65, retinoid isomerohydrolase
all-trans-retinyl-palmitate hydrolase
lutein isomerase
meso-zeaxanthin isomerase
retinal pigment epithelium 65
retinal pigment epithelium 65-like
retinal pigment epithelium-specific 65 kDa protein
retinal pigment epithelium-specific protein 65
retinol isomerase
NP_446014.2
XP_038959207.1
XP_038959208.1
XP_038959210.1
XP_038959211.1
XP_063138717.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053562.3 → NP_446014.2  retinoid isomerohydrolase

    See identical proteins and their annotated locations for NP_446014.2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000002
    UniProtKB/Swiss-Prot
    F1M8Q2, O70276
    UniProtKB/TrEMBL
    A0A8L2QKB1
    Related
    ENSRNOP00000069757.1, ENSRNOT00000078187.3
    Conserved Domains (1) summary
    pfam03055
    Location:21 → 530
    RPE65; Retinal pigment epithelial membrane protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    251425228..251457209
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039103279.2 → XP_038959207.1  retinoid isomerohydrolase isoform X1

    UniProtKB/TrEMBL
    A0A8L2QKB1
    Conserved Domains (1) summary
    pfam03055
    Location:20 → 559
    RPE65; Retinal pigment epithelial membrane protein

  2. XM_039103280.2 → XP_038959208.1  retinoid isomerohydrolase isoform X2

    UniProtKB/TrEMBL
    A0A8L2QKB1
    Conserved Domains (1) summary
    pfam03055
    Location:20 → 523
    RPE65; Retinal pigment epithelial membrane protein

  3. XM_039103282.2 → XP_038959210.1  retinoid isomerohydrolase isoform X4

    UniProtKB/TrEMBL
    A0A8L2QKB1
    Conserved Domains (1) summary
    pfam03055
    Location:4 → 467
    RPE65; Retinal pigment epithelial membrane protein

  4. XM_063282647.1 → XP_063138717.1  retinoid isomerohydrolase isoform X3

    Related
    ENSRNOP00000111603.1, ENSRNOT00000159605.1

  5. XM_039103283.2 → XP_038959211.1  retinoid isomerohydrolase isoform X5

    Conserved Domains (1) summary
    cl10080
    Location:20 → 245
    RPE65; Retinal pigment epithelial membrane protein
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O70276.4 GenPept UniProtKB/Swiss-Prot:O70276

Gene LinkOut

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