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MCM3AP minichromosome maintenance complex component 3 associated protein [ Homo sapiens (human) ]

Gene ID: 8888, updated on 14-Nov-2024

Summary

Official Symbol
MCM3APprovided by HGNC
Official Full Name
minichromosome maintenance complex component 3 associated proteinprovided by HGNC
Primary source
HGNC:HGNC:6946
See related
Ensembl:ENSG00000160294 MIM:603294; AllianceGenome:HGNC:6946
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GANP; SAC3; MAP80; PNRIID
Summary
The minichromosome maintenance protein 3 (MCM3) is one of the MCM proteins essential for the initiation of DNA replication. The protein encoded by this gene is a MCM3 binding protein. It was reported to have phosphorylation-dependent DNA-primase activity, which was up-regulated in antigen immunization induced germinal center. This protein was demonstrated to be an acetyltransferase that acetylates MCM3 and plays a role in DNA replication. The mutagenesis of a nuclear localization signal of MCM3 affects the binding of this protein with MCM3, suggesting that this protein may also facilitate MCM3 nuclear localization. This gene is expressed in the brain or in neuronal tissue. An allelic variant encoding amino acid Lys at 915, instead of conserved Glu, has been identified in patients with mild intellectual disability. [provided by RefSeq, Jan 2014]
Expression
Ubiquitous expression in lymph node (RPKM 12.6), spleen (RPKM 12.4) and 25 other tissues See more
Orthologs
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Genomic context

See MCM3AP in Genome Data Viewer
Location:
21q22.3
Exon count:
29
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 21 NC_000021.9 (46235133..46286265, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 21 NC_060945.1 (44617688..44668894, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 21 NC_000021.8 (47655047..47705525, complement)

Chromosome 21 - NC_000021.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124905045 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:47611464-47612078 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:47612079-47612691 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:47614165-47614666 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:47614667-47615166 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:47621241-47621767 Neighboring gene small nucleolar RNA, C/D box 159 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:47638552-47639452 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:47640419-47640920 Neighboring gene lanosterol synthase Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18598 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13413 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13414 Neighboring gene Sharpr-MPRA regulatory region 3947 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13416 Neighboring gene MCM3AP antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18599 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13417 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13418 Neighboring gene H3K27ac hESC enhancer GRCh37_chr21:47709143-47709725 Neighboring gene H3K27ac hESC enhancer GRCh37_chr21:47709726-47710307 Neighboring gene Sharpr-MPRA regulatory region 4411 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:47715289-47715862 Neighboring gene Sharpr-MPRA regulatory region 1466 Neighboring gene chromosome 21 open reading frame 58 Neighboring gene ybeY metalloendoribonuclease Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:47736113-47736948 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:47737784-47738618 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:47738619-47739453 Neighboring gene ReSE screen-validated silencer GRCh37_chr21:47741059-47741321 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18600 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13419 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13420 Neighboring gene uncharacterized LOC128092249 Neighboring gene pericentrin

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of minichromosome maintenance complex component 3 associated protein (MCM3AP) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag Encapsidation of GANP into virions requires the CA region of HIV-1 Gag and GANP and is associated with HIV-1 genomic RNA PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ44336, FLJ45306, KIAA0572

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables histone H2AK5 acetyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H2AK9 acetyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H2BK12 acetyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H2BK5 acetyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H3 acetyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables histone H3K122 acetyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H3K14 acetyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H3K18 acetyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H3K23 acetyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H3K27 acetyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H3K36 acetyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H3K4 acetyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H3K56 acetyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H3K9 acetyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H4K12 acetyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H4K16 acetyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H4K5 acetyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H4K8 acetyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone acetyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables histone binding IDA
Inferred from Direct Assay
more info
PubMed 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in mRNA export from nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in nucleosome organization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in poly(A)+ mRNA export from nucleus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
 
involved_in somatic hypermutation of immunoglobulin genes IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol HDA PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in nuclear membrane IDA
Inferred from Direct Assay
more info
 
part_of nuclear pore nuclear basket IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleus HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of transcription export complex 2 IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of transcription export complex 2 IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
germinal-center associated nuclear protein
Names
80 kDa MCM3-associated protein
MCM3 acetylating protein
MCM3 acetyltransferase
MCM3 import protein
MCM3 minichromosome maintenance deficient 3 associated protein
germinal center-associated nuclear protein
germinal-centre associated nuclear protein
NP_003897.2
XP_005261260.1
XP_005261261.1
XP_005261262.1
XP_054180926.1
XP_054180927.1
XP_054180928.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_033881.1 RefSeqGene

    Range
    4712..55190
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_003906.5NP_003897.2  germinal-center associated nuclear protein

    See identical proteins and their annotated locations for NP_003897.2

    Status: REVIEWED

    Source sequence(s)
    AA659734, AJ010089, AL079407, AP000471, BC104958
    Consensus CDS
    CCDS13734.1
    UniProtKB/Swiss-Prot
    C9JL56, O60318, Q2M3C1, Q6PJP6, Q9BSY5, Q9UMT4
    UniProtKB/TrEMBL
    B7Z8Z8
    Related
    ENSP00000291688.1, ENST00000291688.6
    Conserved Domains (5) summary
    cd12443
    Location:435506
    RRM_MCM3A_like; RNA recognition motif in 80 kDa MCM3-associated protein (Map80) and similar proteins
    pfam03399
    Location:686910
    SAC3_GANP; SAC3/GANP/Nin1/mts3/eIF-3 p25 family
    pfam16766
    Location:11641234
    CID_GANP; Binding region of GANP to ENY2
    pfam16768
    Location:2291
    NupH_GANP; Nucleoporin homology of Germinal-centre associated nuclear protein
    pfam16769
    Location:12621976
    MCM3AP_GANP; MCM3AP domain of GANP

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000021.9 Reference GRCh38.p14 Primary Assembly

    Range
    46235133..46286265 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005261205.5XP_005261262.1  germinal-center associated nuclear protein isoform X1

    See identical proteins and their annotated locations for XP_005261262.1

    UniProtKB/Swiss-Prot
    C9JL56, O60318, Q2M3C1, Q6PJP6, Q9BSY5, Q9UMT4
    UniProtKB/TrEMBL
    B7Z8Z8
    Related
    ENSP00000380820.1, ENST00000397708.1
    Conserved Domains (5) summary
    cd12443
    Location:435506
    RRM_MCM3A_like; RNA recognition motif in 80 kDa MCM3-associated protein (Map80) and similar proteins
    pfam03399
    Location:686910
    SAC3_GANP; SAC3/GANP/Nin1/mts3/eIF-3 p25 family
    pfam16766
    Location:11641234
    CID_GANP; Binding region of GANP to ENY2
    pfam16768
    Location:2291
    NupH_GANP; Nucleoporin homology of Germinal-centre associated nuclear protein
    pfam16769
    Location:12621976
    MCM3AP_GANP; MCM3AP domain of GANP
  2. XM_005261204.6XP_005261261.1  germinal-center associated nuclear protein isoform X1

    See identical proteins and their annotated locations for XP_005261261.1

    UniProtKB/Swiss-Prot
    C9JL56, O60318, Q2M3C1, Q6PJP6, Q9BSY5, Q9UMT4
    UniProtKB/TrEMBL
    B7Z8Z8
    Conserved Domains (5) summary
    cd12443
    Location:435506
    RRM_MCM3A_like; RNA recognition motif in 80 kDa MCM3-associated protein (Map80) and similar proteins
    pfam03399
    Location:686910
    SAC3_GANP; SAC3/GANP/Nin1/mts3/eIF-3 p25 family
    pfam16766
    Location:11641234
    CID_GANP; Binding region of GANP to ENY2
    pfam16768
    Location:2291
    NupH_GANP; Nucleoporin homology of Germinal-centre associated nuclear protein
    pfam16769
    Location:12621976
    MCM3AP_GANP; MCM3AP domain of GANP
  3. XM_005261203.5XP_005261260.1  germinal-center associated nuclear protein isoform X1

    See identical proteins and their annotated locations for XP_005261260.1

    UniProtKB/Swiss-Prot
    C9JL56, O60318, Q2M3C1, Q6PJP6, Q9BSY5, Q9UMT4
    UniProtKB/TrEMBL
    B7Z8Z8
    Conserved Domains (5) summary
    cd12443
    Location:435506
    RRM_MCM3A_like; RNA recognition motif in 80 kDa MCM3-associated protein (Map80) and similar proteins
    pfam03399
    Location:686910
    SAC3_GANP; SAC3/GANP/Nin1/mts3/eIF-3 p25 family
    pfam16766
    Location:11641234
    CID_GANP; Binding region of GANP to ENY2
    pfam16768
    Location:2291
    NupH_GANP; Nucleoporin homology of Germinal-centre associated nuclear protein
    pfam16769
    Location:12621976
    MCM3AP_GANP; MCM3AP domain of GANP

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060945.1 Alternate T2T-CHM13v2.0

    Range
    44617688..44668894 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054324953.1XP_054180928.1  germinal-center associated nuclear protein isoform X1

  2. XM_054324951.1XP_054180926.1  germinal-center associated nuclear protein isoform X1

  3. XM_054324952.1XP_054180927.1  germinal-center associated nuclear protein isoform X1