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hspX alpha-crystallin [ Mycobacterium tuberculosis H37Rv ]

Gene ID: 887579, updated on 6-Oct-2023

Summary

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Gene symbol
hspX
Gene description
alpha-crystallin
Locus tag
Rv2031c
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
Lineage
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
Also known as
acr
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Genomic context

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Sequence:
NC_000962.3 (2278498..2278932, complement)

NC_000962.3Genomic Context describing neighboring genes Neighboring gene universal stress protein Neighboring gene 6-phosphofructokinase PfkB Neighboring gene hypothetical protein Neighboring gene NAD(P)H nitroreductase Neighboring gene hypothetical protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000962.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Insights into Macrophage Autophagy in Latent Tuberculosis Infection: Role of Heat Shock Protein 16.3. Zhang C, et al. DNA Cell Biol, 2018 May. PMID 29461881
  2. Th0 to Th1 switch of CD4 T cell clones specific from the 16-kDa antigen of Mycobacterium tuberculosis after successful therapy: lack of involvement of epitope repertoire and HLA-DR. Caccamo N, et al. Immunol Lett, 2005 May 15. PMID 15860225
  3. Usefulness of acr expression for monitoring latent Mycobacterium tuberculosis bacilli in 'in vitro' and 'in vivo' experimental models. Gordillo S, et al. Scand J Immunol, 2006 Jul. PMID 16784488
  4. Identification of the mycobacterial subcomponents involved in the release of tumor necrosis factor-related apoptosis-inducing ligand from human neutrophils. Simons MP, et al. Infect Immun, 2007 Mar. PMID 17194806, Free PMC Article
  5. New alternative vaccine component against mycobacterium tuberculosis--heat shock protein 16.3 or its T-cell epitope. Shi C, et al. Scand J Immunol, 2009 Nov. PMID 19874551

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A high affinity DNA aptamer for HspX can be used for accurate diagnosis of tuberculous meningitis.
    Title: Generation and application of DNA aptamers against HspX for accurate diagnosis of tuberculous meningitis.
  2. Hsp16.3 may represent a potential biomarker of Latent tuberculosis infection and novel pharmacological target for anti-tubercular drugs. [review]
    Title: Insights into Macrophage Autophagy in Latent Tuberculosis Infection: Role of Heat Shock Protein 16.3.
  3. results suggest that rIL-10 mediated down-regulation of hspX expression, in the presence of low concentration of rIFN-gamma, could be used as an important strategy to decrease the dormancy of MTB in its host and thus making MTB susceptible to the standard anti-mycobacterial therapy used for treating tuberculosis.
    Title: IL-10 down-regulates the expression of survival associated gene hspX of Mycobacterium tuberculosis in murine macrophage.
  4. The C-terminal extension of Mycobacterium tuberculosis Hsp16.3 regulates its oligomerization, subunit exchange dynamics and chaperone function.
    Title: The C-terminal extension of Mycobacterium tuberculosis Hsp16.3 regulates its oligomerization, subunit exchange dynamics and chaperone function.
  5. DNA-Launched Alphavirus Replicons Encoding a Fusion of Mycobacterial Antigens Acr and Ag85B Are Immunogenic and Protective in a Murine Model of TB Infection.
    Title: DNA-Launched Alphavirus Replicons Encoding a Fusion of Mycobacterial Antigens Acr and Ag85B Are Immunogenic and Protective in a Murine Model of TB Infection.
  6. A HspX-deficient Mycobacterium tuberculosis strain was significantly less virulent than the wild-type Mycobacterium tuberculosis.
    Title: HspX vaccination and role in virulence in the guinea pig model of tuberculosis.
  7. Data indicate that polyclonal antibidy of His-heat shock protein 16.3 (Hsp16.3) has been obtained with good specificity.
    Title: [Preparation of polyclonal antibody for heat shock protein 16.3].
  8. In two models, the metastatic capacity of B16 melanoma cancer cells toward the lungs is remarkably attenuated in mice that receive HspX-immunostimulated dendritic cells.
    Title: Enhancement of tumor-specific T cell-mediated immunity in dendritic cell-based vaccines by Mycobacterium tuberculosis heat shock protein X.
  9. analysis of immunogenicity of a fusion protein containing immunodominant epitopes of Ag85C, MPT51, and HspX from Mycobacterium tuberculosis in mice and active TB infection
    Title: Immunogenicity of a fusion protein containing immunodominant epitopes of Ag85C, MPT51, and HspX from Mycobacterium tuberculosis in mice and active TB infection.
  10. description of how detection of Mycobacterium tuberculosis GlcB or HspX Antigens or devR DNA impacts the rapid diagnosis of tuberculous meningitis in children
    Title: Detection of Mycobacterium tuberculosis GlcB or HspX Antigens or devR DNA impacts the rapid diagnosis of tuberculous meningitis in children.
Submit: New GeneRIF Correction See all GeneRIFs (18)

General gene information

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Homology

General protein information

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Preferred Names
alpha-crystallin
NP_216547.1
  • heat shock protein HspX; alpha-crystallin homolog (14 kDa antigen) (HSP16.3)

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000962.3 Reference assembly

    Range
    2278498..2278932 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_216547.1 alpha-crystallin [Mycobacterium tuberculosis H37Rv]

    See identical proteins and their annotated locations for NP_216547.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    R4M816
    Conserved Domains (1) summary
    pfam00011
    Location:48 → 140
    HSP20; Hsp20/alpha crystallin family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P9WMK1.1

Gene LinkOut

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Molecular Biology Databases
Research Materials