ptpA protein-tyrosine-phosphatase [Mycobacterium tuberculosis H37Rv] - Gene

Summary

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Gene symbol: ptpA
Gene description: protein-tyrosine-phosphatase
Locus tag: Rv2234
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
Lineage: Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
Also known as: MPtpA
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Genomic context

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Sequence:: NC_000962.3 (2507146..2507637)

NC_000962.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_000962.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Characteristics of Mycobacterium tuberculosis PtpA interaction and activity on the alpha subunit of human mitochondrial trifunctional protein, a key enzyme of lipid metabolism.
Title: Characteristics of Mycobacterium tuberculosis PtpA interaction and activity on the alpha subunit of human mitochondrial trifunctional protein, a key enzyme of lipid metabolism.
Oxidation of the Mycobacterium tuberculosis key virulence factor protein tyrosine phosphatase A (MptpA) reduces its phosphatase activity.
Title: Oxidation of the Mycobacterium tuberculosis key virulence factor protein tyrosine phosphatase A (MptpA) reduces its phosphatase activity.
The authors report for the first time that PtpA regulates mycobacterial ATP synthase alpha subunit and the effect is independent of its phosphatase activity.
Title: ATP synthase, an essential enzyme in growth and multiplication is modulated by protein tyrosine phosphatase in Mycobacterium tuberculosis H37Ra.
PtpA enters the nucleus of host cells and regulates the expression of host genes,GADD45A.
Title: The mycobacterial phosphatase PtpA regulates the expression of host genes and promotes cell proliferation.
These results indicate that members of two independent families of protein kinases tune PtpA activity in Mycobacterium tuberculosis
Title: Phosphorylation control of protein tyrosine phosphatase A activity in Mycobacterium tuberculosis.
PtpA has a role in promoting anti-apoptotic activity of protein-dependent dephosphorylation of host GSK3alpha
Title: Mycobacterium tuberculosis promotes anti-apoptotic activity of the macrophage by PtpA protein-dependent dephosphorylation of host GSK3α.
Studies on the regioselectivity and kinetics of the action of trypsin on proinsulin and its derivatives using mass spectrometry.
Title: S-nitrosylation of Mycobacterium tuberculosis tyrosine phosphatase A (PtpA) induces its structural instability.
The requirement for PtpA differs in mouse and human infections, and that mice are not a suitable infection model for the study of PtpA.
Title: Protein tyrosine phosphatase PtpA is not required for Mycobacterium tuberculosis growth in mice.
Genetic deletion of ptpA attenuates Mycobacterium tuberculosis growth in human macrophages and identify VPS33B, a regulator of membrane fusion, as a PtpA substrate.
Title: Mycobacterium tuberculosis virulence is mediated by PtpA dephosphorylation of human vacuolar protein sorting 33B.
conserved residues Cys11, Arg17, and Asp126 in the catalytic mechanism of MPtpA revealed the reaction mechanism followed by this LMWPTPase is similar to the other PTPases.
Title: Analyzing the catalytic mechanism of MPtpA: a low molecular weight protein tyrosine phosphatase from Mycobacterium tuberculosis through site-directed mutagenesis.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

General protein information

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Preferred Names: protein-tyrosine-phosphatase

NP_216750.1

phosphotyrosine protein phosphatase (PTPase) (LMW phosphatase), low molecular weight protein-tyrosine-phosphatase

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_000962.3 Reference assembly

Range

2507146..2507637

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NP_216750.1 protein-tyrosine-phosphatase [Mycobacterium tuberculosis H37Rv]

See identical proteins and their annotated locations for NP_216750.1

Status: PROVISIONAL

UniProtKB/TrEMBL

A0A2I7W8W8

Conserved Domains (1) summary

cd16343
Location:6 → 149

LMWPTP; Low molecular weight protein tyrosine phosphatase