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alkA bifunctional regulatory protein/DNA repair enzyme AlkA [ Mycobacterium tuberculosis H37Rv ]

Gene ID: 886916, updated on 6-Jun-2024

Summary

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Gene symbol
alkA
Gene description
bifunctional regulatory protein/DNA repair enzyme AlkA
Locus tag
Rv1317c
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
Lineage
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
Also known as
ada
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Genomic context

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Sequence:
NC_000962.3 (1477628..1479118, complement)

NC_000962.3Genomic Context describing neighboring genes Neighboring gene 23S ribosomal RNA Neighboring gene 5S ribosomal RNA Neighboring gene methylated-DNA--protein-cysteine methyltransferase Neighboring gene adenylate cyclase Neighboring gene adenylate cyclase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000962.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A non-sense mutation in the putative anti-mutator gene ada/alkA of Mycobacterium tuberculosis and M. bovis isolates suggests convergent evolution. Nouvel LX, et al. BMC Microbiol, 2007 May 16. PMID 17506895, Free PMC Article
  2. The ada operon of Mycobacterium tuberculosis encodes two DNA methyltransferases for inducible repair of DNA alkylation damage. Yang M, et al. DNA Repair (Amst), 2011 Jun 10. PMID 21570366
  3. TubercuList--10 years after. Lew JM, et al. Tuberculosis (Edinb), 2011 Jan. PMID 20980199
  4. Re-annotation of the genome sequence of Mycobacterium tuberculosis H37Rv. Camus JC, et al. Microbiology (Reading), 2002 Oct. PMID 12368430
  5. Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Cole ST, et al. Nature, 1998 Jun 11. PMID 9634230

GeneRIFs: Gene References Into Functions

General gene information

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Homology

General protein information

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Preferred Names
bifunctional regulatory protein/DNA repair enzyme AlkA
NP_215833.1
  • regulatory protein of adaptative response (methylphosphotriester-DNA--protein-cysteine S-methyltransferase)

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000962.3 Reference assembly

    Range
    1477628..1479118 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_215833.1 bifunctional regulatory protein/DNA repair enzyme AlkA [Mycobacterium tuberculosis H37Rv]

    See identical proteins and their annotated locations for NP_215833.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0AAD2IRV4
    Conserved Domains (2) summary
    COG0122
    Location:210 → 494
    AlkA; 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [Replication, recombination and repair]
    COG2169
    Location:1 → 180
    AdaA; Methylphosphotriester-DNA--protein-cysteine methyltransferase (N-terminal fragment of Ada), contains Zn-binding and two AraC-type DNA-binding domains [Replication, recombination and repair]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P9WJW3.1

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