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lprG lipoprotein LprG [ Mycobacterium tuberculosis H37Rv ]

Gene ID: 886700, updated on 6-Aug-2024

Summary

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Gene symbol
lprG
Gene description
lipoprotein LprG
Locus tag
Rv1411c
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
Lineage
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
Also known as
P27
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Genomic context

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Sequence:
NC_000962.3 (1587772..1588482, complement)

NC_000962.3Genomic Context describing neighboring genes Neighboring gene ribulose-phosphate 3-epimerase Neighboring gene bifunctional riboflavin biosynthesis diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino) uracil reductase Neighboring gene aminoglycosides/tetracycline-transport integral membrane protein Neighboring gene riboflavin synthase Neighboring gene hypothetical protein Neighboring gene hypothetical protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000962.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Protein O-mannosylation deficiency increases LprG-associated lipoarabinomannan release by Mycobacterium tuberculosis and enhances the TLR2-associated inflammatory response. Alonso H, et al. Sci Rep, 2017 Aug 11. PMID 28801649, Free PMC Article
  2. A Screen for Protein-Protein Interactions in Live Mycobacteria Reveals a Functional Link between the Virulence-Associated Lipid Transporter LprG and the Mycolyltransferase Antigen 85A. Touchette MH, et al. ACS Infect Dis, 2017 May 12. PMID 28276676, Free PMC Article
  3. Mycobacterium tuberculosis lipoprotein LprG binds lipoarabinomannan and determines its cell envelope localization to control phagolysosomal fusion. Shukla S, et al. PLoS Pathog, 2014 Oct. PMID 25356793, Free PMC Article
  4. Aggravated infection in mice co-administered with Mycobacterium tuberculosis and the 27-kDa lipoprotein. Hovav AH, et al. Microbes Infect, 2006 Jun. PMID 16815070
  5. TubercuList--10 years after. Lew JM, et al. Tuberculosis (Edinb), 2011 Jan. PMID 20980199

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Here, the authors demonstrated that the Mycobacterium tuberculosis mutant (Deltapmt) deficient for protein O-mannosylation exhibits enhanced release of lipoarabinomannan (LAM) in a complex with LprG, a lipoprotein required for LAM translocation to the cell surface.
    Title: Protein O-mannosylation deficiency increases LprG-associated lipoarabinomannan release by Mycobacterium tuberculosis and enhances the TLR2-associated inflammatory response.
  2. A screen for protein-protein interactions reveals a functional link between the virulence-associated lipid transporter LprG and the mycolyltransferase antigen 85A.
    Title: A Screen for Protein-Protein Interactions in Live Mycobacteria Reveals a Functional Link between the Virulence-Associated Lipid Transporter LprG and the Mycolyltransferase Antigen 85A.
  3. LprG binding to lipoarabinomannan (LAM) facilitates its transfer from the plasma membrane into the cell envelope.
    Title: Mycobacterium tuberculosis lipoprotein LprG binds lipoarabinomannan and determines its cell envelope localization to control phagolysosomal fusion.
  4. data suggest that the 27-kDa lipoprotein plays a role in Mtb infection by inducing increased suppression of the immune response due to elevated nitric oxide production
    Title: Aggravated infection in mice co-administered with Mycobacterium tuberculosis and the 27-kDa lipoprotein.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

General protein information

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Preferred Names
lipoprotein LprG
NP_215927.1
  • A core mycobacterial gene; conserved in mycobacterial strains (See Marmiesse et al., 2004 PMID:14766927).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000962.3 Reference assembly

    Range
    1587772..1588482 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_215927.1 lipoprotein LprG [Mycobacterium tuberculosis H37Rv]

    See identical proteins and their annotated locations for NP_215927.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A0E9AD62
    Conserved Domains (1) summary
    pfam07161
    Location:40 → 230
    LppX_LprAFG; LppX_LprAFG lipoprotein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P9WK45.1

Gene LinkOut

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