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fgd1 F420-dependent glucose-6-phosphate dehydrogenase [ Mycobacterium tuberculosis H37Rv ]

Gene ID: 886418, updated on 4-Apr-2024

Summary

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Gene symbol
fgd1
Gene description
F420-dependent glucose-6-phosphate dehydrogenase
Locus tag
Rv0407
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
Lineage
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
Also known as
fgd
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Genomic context

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Sequence:
NC_000962.3 (490783..491793)

NC_000962.3Genomic Context describing neighboring genes Neighboring gene long-chain-fatty-acid--AMP ligase FadD30 Neighboring gene membrane bound polyketide synthase Neighboring gene beta lactamase-like protein Neighboring gene phosphate acetyltransferase Neighboring gene acetate kinase Neighboring gene serine/threonine-protein kinase PknG Neighboring gene glutamine-binding lipoprotein GlnH

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000962.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Crystal structures of F420-dependent glucose-6-phosphate dehydrogenase FGD1 involved in the activation of the anti-tuberculosis drug candidate PA-824 reveal the basis of coenzyme and substrate binding. Bashiri G, et al. J Biol Chem, 2008 Jun 20. PMID 18434308
  2. Differential expression of immunogenic proteins on virulent Mycobacterium tuberculosis clinical isolates. Schierloh P, et al. Biomed Res Int, 2014. PMID 25105140, Free PMC Article
  3. TubercuList--10 years after. Lew JM, et al. Tuberculosis (Edinb), 2011 Jan. PMID 20980199
  4. Re-annotation of the genome sequence of Mycobacterium tuberculosis H37Rv. Camus JC, et al. Microbiology (Reading), 2002 Oct. PMID 12368430
  5. Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Cole ST, et al. Nature, 1998 Jun 11. PMID 9634230

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. recombinant Rv2241, Rv0009, Rv0407, and Rv2624c proteins were produced for testing specific antibody responses. We found that these proteins induced humoral immune responses in patients with drug-sensitive and drug-resistant tuberculosis
    Title: Differential expression of immunogenic proteins on virulent Mycobacterium tuberculosis clinical isolates.
  2. crystallographic analysis of the F420-dependent glucose-6-phosphate dehydrogenase FGD1 involved in the activation of the anti-tuberculosis drug candidate PA-824
    Title: Crystal structures of F420-dependent glucose-6-phosphate dehydrogenase FGD1 involved in the activation of the anti-tuberculosis drug candidate PA-824 reveal the basis of coenzyme and substrate binding.
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Pathways from PubChem

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General gene information

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Homology

General protein information

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Preferred Names
F420-dependent glucose-6-phosphate dehydrogenase

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000962.3 Reference assembly

    Range
    490783..491793
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_214921.1 F420-dependent glucose-6-phosphate dehydrogenase [Mycobacterium tuberculosis H37Rv]

    See identical proteins and their annotated locations for NP_214921.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A2I7W3F7
    Conserved Domains (1) summary
    TIGR03554
    Location:3 → 333
    F420_G6P_DH; glucose-6-phosphate dehydrogenase (coenzyme-F420)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P9WNE1.1

Gene LinkOut

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