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rpfB resuscitation-promoting factor RpfB [ Mycobacterium tuberculosis H37Rv ]

Gene ID: 886048, updated on 27-Nov-2023

Summary

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Gene symbol
rpfB
Gene description
resuscitation-promoting factor RpfB
Locus tag
Rv1009
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
Lineage
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
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Genomic context

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Sequence:
NC_000962.3 (1128091..1129179)

NC_000962.3Genomic Context describing neighboring genes Neighboring gene methionine--tRNA ligase Neighboring gene deoxyribonuclease TatD Neighboring gene rRNA small subunit methyltransferase A Neighboring gene 4-diphosphocytidyl-2C-methyl-D-erythritol kinase Neighboring gene hypothetical protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000962.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. [SIMULATION OF CHRONIC TUBERCULOSIS INFECTION IN MICE BY INTRAPERITONEAL INOCULATION AND THE TESTING OF AMINOGUANIDINE-INDUCED ACTIVATION OF RPF GENE/DELETION MUTANTS OF THE H37Rv STRAIN]. . Tuberk Biolezni Legkih, 2010. PMID 27534027
  2. Carbohydrate recognition by RpfB from Mycobacterium tuberculosis unveiled by crystallographic and molecular dynamics analyses. Squeglia F, et al. Biophys J, 2013 Jun 4. PMID 23746526, Free PMC Article
  3. Expression, purification, crystallization and preliminary X-ray crystallographic analysis of a major fragment of the resuscitation-promoting factor RpfB from Mycobacterium tuberculosis. Ruggiero A, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2011 Jan 1. PMID 21206053, Free PMC Article
  4. A partner for the resuscitation-promoting factors of Mycobacterium tuberculosis. Hett EC, et al. Mol Microbiol, 2007 Nov. PMID 17919286
  5. Expression, purification, crystallization and preliminary X-ray crystallographic analysis of a resuscitation-promoting factor from Mycobacterium tuberculosis. Ruggiero A, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2007 Oct 1. PMID 17909292, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Identification of a regulatory element in the 5' untranslated region (UTR) of rpfB. This element is a transcriptionally regulated RNA switch/riboswitch candidate.
    Title: Cell-wall synthesis and ribosome maturation are co-regulated by an RNA switch in Mycobacterium tuberculosis.
  2. Detection IgG1 antibodies against M. tuberculosis antigens, including DosR and Rpf proteins, may represent an additional tool in the diagnosis of tuberculosis.
    Title: Detection of IgG1 antibodies against Mycobacterium tuberculosis DosR and Rpf antigens in tuberculosis patients before and after chemotherapy.
  3. rpf gene products involve in the transition of latent (chronic) to active form of tuberculosis.
    Title: [SIMULATION OF CHRONIC TUBERCULOSIS INFECTION IN MICE BY INTRAPERITONEAL INOCULATION AND THE TESTING OF AMINOGUANIDINE-INDUCED ACTIVATION OF RPF GENE/DELETION MUTANTS OF THE H37Rv STRAIN].
  4. These experiments suggest that MtrA functions as a repressor of rpfB transcription.
    Title: MtrA, an essential response regulator of the MtrAB two-component system, regulates the transcription of resuscitation-promoting factor B of Mycobacterium tuberculosis.
  5. Carbohydrate recognition by RpfB
    Title: Carbohydrate recognition by RpfB from Mycobacterium tuberculosis unveiled by crystallographic and molecular dynamics analyses.
  6. RpfB regulates innate immunity and activates adaptive immunity through TLR4.
    Title: Mycobacterium tuberculosis RpfB drives Th1-type T cell immunity via a TLR4-dependent activation of dendritic cells.
  7. The crystal structure of the catalytic domain of RpfB from Mycobacterium tuberculosis.
    Title: Molecular determinants of inactivation of the resuscitation promoting factor B from Mycobacterium tuberculosis.
  8. Results provide the first structural characterization of a DUF348 domain reported and will shed light on the functional role of the noncatalytic domains of RpfB.
    Title: Expression, purification, crystallization and preliminary X-ray crystallographic analysis of a major fragment of the resuscitation-promoting factor RpfB from Mycobacterium tuberculosis.
  9. DeltarpfAB exhibited an altered colony morphology and exhibited deficiency in reactivation induced in C57BL/6 mice.
    Title: A Mycobacterium tuberculosis Rpf double-knockout strain exhibits profound defects in reactivation from chronic tuberculosis and innate immunity phenotypes.
  10. In this study, the rpfA-E genes were shown to be collectively dispensable for growth of M. tuberculosis in broth culture.
    Title: The resuscitation-promoting factors of Mycobacterium tuberculosis are required for virulence and resuscitation from dormancy but are collectively dispensable for growth in vitro.
Submit: New GeneRIF Correction See all GeneRIFs (12)

General gene information

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Homology

General protein information

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Preferred Names
resuscitation-promoting factor RpfB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000962.3 Reference assembly

    Range
    1128091..1129179
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_215525.1 resuscitation-promoting factor RpfB [Mycobacterium tuberculosis H37Rv]

    See identical proteins and their annotated locations for NP_215525.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A2Z3DFP3, A0A2Z3DIC7
    Conserved Domains (2) summary
    COG3583
    Location:15 → 302
    YabE; Uncharacterized conserved protein YabE, contains G5 and tandem DUF348 domains [Function unknown]
    pfam06737
    Location:281 → 355
    Transglycosylas; Transglycosylase-like domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P9WG29.1

Gene LinkOut

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Molecular Biology Databases
Research Materials