CFLAR CASP8 and FADD like apoptosis regulator [Homo sapiens (human)] - Gene

Summary

Official Symbol: CFLARprovided by HGNC
Official Full Name: CASP8 and FADD like apoptosis regulatorprovided by HGNC
Primary source: HGNC:HGNC:1876
See related: Ensembl:ENSG00000003402 MIM:603599; AllianceGenome:HGNC:1876
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: CASH; FLIP; MRIT; CLARP; FLAME; cFLIP; Casper; FLAME1; c-FLIP; FLAME-1; I-FLICE; c-FLIPL; c-FLIPR; c-FLIPS; CASP8AP1
Summary: The protein encoded by this gene is a regulator of apoptosis and is structurally similar to caspase-8. However, the encoded protein lacks caspase activity and appears to be itself cleaved into two peptides by caspase-8. Several transcript variants encoding different isoforms have been found for this gene, and partial evidence for several more variants exists. [provided by RefSeq, Feb 2011]
Expression: Ubiquitous expression in fat (RPKM 11.3), bone marrow (RPKM 9.5) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 2q33.1

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	2	NC_000002.12 (201116164..201176687)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	2	NC_060926.1 (201599606..201660139)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	2	NC_000002.11 (201980887..202041410)

Chromosome 2 - NC_000002.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

cFLIPS regulates alternative NLRP3 inflammasome activation in human monocytes.
Title: cFLIP(S) regulates alternative NLRP3 inflammasome activation in human monocytes.
c-FLIP promotes drug resistance in non-small-cell lung cancer cells via upregulating FoxM1 expression.
Title: c-FLIP promotes drug resistance in non-small-cell lung cancer cells via upregulating FoxM1 expression.
The interaction of CFLAR with p130Cas promotes cell migration.
Title: The interaction of CFLAR with p130Cas promotes cell migration.
cFLIP downregulation is an early event required for endoplasmic reticulum stress-induced apoptosis in tumor cells.
Title: cFLIP downregulation is an early event required for endoplasmic reticulum stress-induced apoptosis in tumor cells.
The deubiquitinase Usp27x as a novel regulator of cFLIPL protein expression and sensitizer to death-receptor-induced apoptosis.
Title: The deubiquitinase Usp27x as a novel regulator of cFLIP(L) protein expression and sensitizer to death-receptor-induced apoptosis.
Lactucin induces apoptosis through reactive oxygen species-mediated BCL-2 and CFLARL downregulation in Caki-1 cells.
Title: Lactucin induces apoptosis through reactive oxygen species-mediated BCL-2 and CFLAR(L) downregulation in Caki-1 cells.
Cellular FLICE-like inhibitory protein (cFLIP) critically maintains apoptotic resistance in human lens epithelial cells.
Title: Cellular FLICE-like inhibitory protein (cFLIP) critically maintains apoptotic resistance in human lens epithelial cells.
The SCF(Skp2) ubiquitin ligase complex modulates TRAIL-R2-induced apoptosis by regulating FLIP(L).
Title: The SCF(Skp2) ubiquitin ligase complex modulates TRAIL-R2-induced apoptosis by regulating FLIP(L).
Superoxide induced inhibition of death receptor signaling is mediated via induced expression of apoptosis inhibitory protein cFLIP.
Title: Superoxide induced inhibition of death receptor signaling is mediated via induced expression of apoptosis inhibitory protein cFLIP.
Co-treatment of birinapant with TRAIL synergistically induces apoptosis by downregulating cFLIP(L) in MDA-MB-453 cell lines.
Title: Co-treatment of birinapant with TRAIL synergistically induces apoptosis by downregulating cFLIP(L) in MDA-MB-453 cell lines.

Submit: New GeneRIF Correction See all GeneRIFs (299)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genetics of rheumatoid arthritis contributes to biology and drug discovery. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Replication interactions

Interaction	Pubs
Knockdown of CASP8 and FADD-like apoptosis regulator (CFLAR) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells	PubMed

Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	Trafficking of HIV-1 gp120 to lipid rafts is blocked by expression of cFLIP	PubMed
	env	HIV-1 Env-pseudotyped virus-infected monocyte-derived macrophage cells downregulate expression of TRAIL decoy receptors DcR1 and DcR2, and cellular FLICE-inhibitory protein (c-FLIP)	PubMed
	env	c-FLIPL inhibits Bax activation via modulating PKC expression at the transcriptional level involving AP-2 during gp120 treatment	PubMed
capsid	gag	cFLIP-induced upregulation of TRIM-5alpha expression inhibits HIV-1 CA expression	PubMed
	gag	Trafficking of HIV-1 CA to lipid rafts is blocked by expression of cFLIP, which causes decreased levels of TSG101 and Alix at the plasma membrane	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH79734 (e-PCR)
- UniSTS:87303

CFLAR_2686 (e-PCR)
- UniSTS:462098

sY3084 (e-PCR)
- UniSTS:515126

G54454 (e-PCR)
- UniSTS:140855

WI-12098 (e-PCR)
- UniSTS:15976

D11S3076 (e-PCR)
- UniSTS:152173

RH102289 (e-PCR)
- UniSTS:96623

MARC_12239-12240:1005141928:1 (e-PCR)
- UniSTS:267379

RH68847 (e-PCR)
- UniSTS:22671

L18441 (e-PCR)
- UniSTS:71348

RH45502 (e-PCR)
- UniSTS:79054

A008B37 (e-PCR)
- UniSTS:67797

GDB:631802 (e-PCR)
- UniSTS:158429

RH98318 (e-PCR)
- UniSTS:86750

SHGC-84793 (e-PCR)
- UniSTS:104164

RH79972 (e-PCR)
- UniSTS:84469

D2S2141 (e-PCR)
- UniSTS:17406

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables cysteine-type endopeptidase activity involved in apoptotic signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
enables cysteine-type endopeptidase activity involved in execution phase of apoptosis	IBA Inferred from Biological aspect of Ancestor more info
enables death receptor binding	IEA Inferred from Electronic Annotation more info
enables enzyme activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables enzyme activator activity	IDA Inferred from Direct Assay more info	PubMed
enables protease binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in apoptotic signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in cellular response to dexamethasone stimulus	IEA Inferred from Electronic Annotation more info
involved_in cellular response to epidermal growth factor stimulus	IEA Inferred from Electronic Annotation more info
involved_in cellular response to estradiol stimulus	IEA Inferred from Electronic Annotation more info
involved_in cellular response to hypoxia	IEA Inferred from Electronic Annotation more info
involved_in cellular response to insulin stimulus	IEA Inferred from Electronic Annotation more info
involved_in cellular response to nitric oxide	IEA Inferred from Electronic Annotation more info
involved_in erythrocyte differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in execution phase of apoptosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in keratinocyte differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of apoptotic process	TAS Traceable Author Statement more info	PubMed
involved_in negative regulation of cardiac muscle cell apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cellular response to transforming growth factor beta stimulus	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of extrinsic apoptotic signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of extrinsic apoptotic signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of extrinsic apoptotic signaling pathway via death domain receptors	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of extrinsic apoptotic signaling pathway via death domain receptors	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of hepatocyte apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of myoblast fusion	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of reactive oxygen species biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in neuron differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of ERK1 and ERK2 cascade	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of NF-kappaB transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of canonical NF-kappaB signal transduction	IEP Inferred from Expression Pattern more info	PubMed
involved_in positive regulation of extracellular matrix organization	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of glomerular mesangial cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of hepatocyte proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of neuron apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of neuron projection development	IEA Inferred from Electronic Annotation more info
involved_in proteolysis	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of necroptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of skeletal muscle satellite cell proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to testosterone	IEA Inferred from Electronic Annotation more info
involved_in skeletal muscle atrophy	ISS Inferred from Sequence or Structural Similarity more info
involved_in skeletal muscle tissue development	ISS Inferred from Sequence or Structural Similarity more info
involved_in skeletal muscle tissue regeneration	ISS Inferred from Sequence or Structural Similarity more info
involved_in skeletal myofibril assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in wound healing	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of CD95 death-inducing signaling complex	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	TAS Traceable Author Statement more info
part_of death-inducing signaling complex	IBA Inferred from Biological aspect of Ancestor more info
part_of death-inducing signaling complex	IDA Inferred from Direct Assay more info	PubMed
part_of ripoptosome	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: CASP8 and FADD-like apoptosis regulator

Names: FADD-like antiapoptotic molecule 1; MACH-related inducer of toxicity; caspase homolog; caspase-eight-related protein; caspase-like apoptosis regulatory protein; caspase-related inducer of apoptosis; cellular FLICE-like inhibitory protein; inhibitor of FLICE; testis secretory sperm-binding protein Li 233m; usurpin beta

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_029005.2 RefSeqGene

Range

5002..65525

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001127183.4 → NP_001120655.1 CASP8 and FADD-like apoptosis regulator isoform 1

See identical proteins and their annotated locations for NP_001120655.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same isoform (1).

Source sequence(s)

AC007283

Consensus CDS

CCDS2337.1

UniProtKB/Swiss-Prot

B4DJE0, B7Z9F9, O14673, O14674, O14675, O15137, O15138, O15356, O15510, O15519, O43618, O43619, O43620, O60458, O60459, Q53TS6, Q54AF1, Q96TE4, Q9UEW1

UniProtKB/TrEMBL

A0A024R3Y4, A0A024R3Z7

Related

ENSP00000399420.2, ENST00000423241.6

Conserved Domains (3) summary

smart00115
Location:244 → 479

CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues

cd08337
Location:1 → 80

DED_c-FLIP_r1; Death Effector Domain, repeat 1, of cellular FLICE-Inhibitory Protein

cd08340
Location:91 → 171

DED_c-FLIP_r2; Death Effector Domain, repeat 2, of cellular FLICE-Inhibitory Protein
NM_001127184.4 → NP_001120656.1 CASP8 and FADD-like apoptosis regulator isoform 2

See identical proteins and their annotated locations for NP_001120656.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) represents use of an alternate coding exon that results in a shorter protein isoform (2) with a distinct C-terminus. Variants 3, 12, and 13 all encode the same isoform (2).

Source sequence(s)

AC007283

Consensus CDS

CCDS46487.1

UniProtKB/TrEMBL

B4DMB6

Related

ENSP00000339335.6, ENST00000341222.10

Conserved Domains (2) summary

cd08337
Location:1 → 80

DED_c-FLIP_r1; Death Effector Domain, repeat 1, of cellular FLICE-Inhibitory Protein

cd08340
Location:91 → 171

DED_c-FLIP_r2; Death Effector Domain, repeat 2, of cellular FLICE-Inhibitory Protein
NM_001202515.1 → NP_001189444.1 CASP8 and FADD-like apoptosis regulator isoform 3

See identical proteins and their annotated locations for NP_001189444.1

Status: REVIEWED

Description

Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (3) is shorter at the N-terminus compared to isoform 1.

Source sequence(s)

AC007283, AF041459, BM969271

UniProtKB/Swiss-Prot

O15519

Conserved Domains (1) summary

smart00115
Location:1 → 234

CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues
NM_001202516.3 → NP_001189445.1 CASP8 and FADD-like apoptosis regulator isoform 4

See identical proteins and their annotated locations for NP_001189445.1

Status: REVIEWED

Description

Transcript Variant: This variant (5) lacks an alternate in-frame segment compared to variant 1. The resulting isoform (4) has the same N- and C-termini but is shorter compared to isoform 1.

Source sequence(s)

AC007283

Consensus CDS

CCDS56157.1

Related

ENSP00000345807.6, ENST00000341582.10

Conserved Domains (3) summary

smart00115
Location:209 → 444

CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues

cd08337
Location:1 → 80

DED_c-FLIP_r1; Death Effector Domain, repeat 1, of cellular FLICE-Inhibitory Protein

cd08340
Location:91 → 171

DED_c-FLIP_r2; Death Effector Domain, repeat 2, of cellular FLICE-Inhibitory Protein
NM_001202517.3 → NP_001189446.1 CASP8 and FADD-like apoptosis regulator isoform 5

See identical proteins and their annotated locations for NP_001189446.1

Status: REVIEWED

Description

Transcript Variant: This variant (6) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (5) is shorter at the N-terminus compared to isoform 1. Variants 6, 14, and 15 all encode the same isoform (5).

Source sequence(s)

AC007283

Consensus CDS

CCDS56158.1

UniProtKB/TrEMBL

B4E361

Related

ENSP00000413270.1, ENST00000443227.5

Conserved Domains (2) summary

smart00115
Location:148 → 383

CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues

cd08340
Location:1 → 75

DED_c-FLIP_r2; Death Effector Domain, repeat 2, of cellular FLICE-Inhibitory Protein
NM_001202518.2 → NP_001189447.1 CASP8 and FADD-like apoptosis regulator isoform 6

See identical proteins and their annotated locations for NP_001189447.1

Status: REVIEWED

Description

Transcript Variant: This variant (7) differs in the 5' UTR and coding sequence and the 3' UTR and coding sequence compared to variant 1. The resulting isoform (6) is shorter at the N-terminus and has a shorter and distinct C-terminus compared to isoform 1. Variants 7 and 8 both encode isoform 6.

Source sequence(s)

AC007283, AK304585, BM969271, CD699251

Consensus CDS

CCDS59436.1

UniProtKB/TrEMBL

B4E361

Related

ENSP00000471805.1, ENST00000479953.6

Conserved Domains (2) summary

cd08340
Location:1 → 75

DED_c-FLIP_r2; Death Effector Domain, repeat 2, of cellular FLICE-Inhibitory Protein

cl00042
Location:148 → 337

CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
NM_001202519.3 → NP_001189448.1 CASP8 and FADD-like apoptosis regulator isoform 6

See identical proteins and their annotated locations for NP_001189448.1

Status: REVIEWED

Description

Transcript Variant: This variant (8) differs in the 5' UTR and coding sequence and the 3' UTR and coding sequence compared to variant 1. The resulting isoform (6) is shorter at the N-terminus and has a shorter and distinct C-terminus compared to isoform 1. Variants 7 and 8 both encode isoform 6.

Source sequence(s)

AC007283

Consensus CDS

CCDS59436.1

UniProtKB/TrEMBL

B4E361

Conserved Domains (2) summary

cd08340
Location:1 → 75

DED_c-FLIP_r2; Death Effector Domain, repeat 2, of cellular FLICE-Inhibitory Protein

cl00042
Location:148 → 337

CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
NM_001308042.3 → NP_001294971.1 CASP8 and FADD-like apoptosis regulator isoform 7

See identical proteins and their annotated locations for NP_001294971.1

Status: REVIEWED

Description

Transcript Variant: This variant (9) differs in the 5' UTR and contains an alternate 3' terminal exon, compared to variant 1, resulting in a novel 3' coding region and distinct 3' UTR. The resulting isoform (7) is shorter and has a distinct C-terminus compared to isoform 1. Variants 9 and 11 both encode the same isoform (7).

Source sequence(s)

AC007283

Consensus CDS

CCDS77505.1

UniProtKB/TrEMBL

A0A336TY74

Conserved Domains (3) summary

cd08337
Location:1 → 80

DED_c-FLIP_r1; Death Effector Domain, repeat 1, of cellular FLICE-Inhibitory Protein

cd08340
Location:91 → 171

DED_c-FLIP_r2; Death Effector Domain, repeat 2, of cellular FLICE-Inhibitory Protein

cl00042
Location:244 → 433

CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
NM_001308043.2 → NP_001294972.1 CASP8 and FADD-like apoptosis regulator isoform 8

Status: REVIEWED

Description

Transcript Variant: This variant (10) lacks multiple exons in the central and 3' coding regions, and includes an alternate 3' terminal exon, compared to variant 1. The resulting isoform (8) is significantly shorter and has a distinct C-terminus compared to isoform 1.

Source sequence(s)

AB209600, AC007283, DC375144

Consensus CDS

CCDS77503.1

UniProtKB/TrEMBL

E9PAP3, Q59F61

Related

ENSP00000378580.2, ENST00000395148.6

Conserved Domains (2) summary

cd08337
Location:1 → 80

DED_c-FLIP_r1; Death Effector Domain, repeat 1, of cellular FLICE-Inhibitory Protein

cd08340
Location:91 → 171

DED_c-FLIP_r2; Death Effector Domain, repeat 2, of cellular FLICE-Inhibitory Protein
NM_001351590.2 → NP_001338519.1 CASP8 and FADD-like apoptosis regulator isoform 7

Status: REVIEWED

Description

Transcript Variant: This variant (11), as well as variant 9, encodes isoform 7.

Source sequence(s)

AC007283

Consensus CDS

CCDS77505.1

UniProtKB/TrEMBL

A0A336TY74

Related

ENSP00000411535.1, ENST00000457277.5

Conserved Domains (3) summary

cd08337
Location:1 → 80

DED_c-FLIP_r1; Death Effector Domain, repeat 1, of cellular FLICE-Inhibitory Protein

cd08340
Location:91 → 171

DED_c-FLIP_r2; Death Effector Domain, repeat 2, of cellular FLICE-Inhibitory Protein

cl00042
Location:244 → 433

CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
NM_001351591.2 → NP_001338520.1 CASP8 and FADD-like apoptosis regulator isoform 2

Status: REVIEWED

Description

Transcript Variant: This variant (12), as well as variants 3 and 13, encodes isoform 2.

Source sequence(s)

AC007283

Consensus CDS

CCDS46487.1

UniProtKB/TrEMBL

B4DMB6

Related

ENSP00000406775.1, ENST00000440180.5

Conserved Domains (2) summary

cd08337
Location:1 → 80

DED_c-FLIP_r1; Death Effector Domain, repeat 1, of cellular FLICE-Inhibitory Protein

cd08340
Location:91 → 171

DED_c-FLIP_r2; Death Effector Domain, repeat 2, of cellular FLICE-Inhibitory Protein
NM_001351592.2 → NP_001338521.1 CASP8 and FADD-like apoptosis regulator isoform 2

Status: REVIEWED

Description

Transcript Variant: This variant (13), as well as variants 3 and 12, encodes isoform 2.

Source sequence(s)

AC007283

Consensus CDS

CCDS46487.1

UniProtKB/TrEMBL

B4DMB6

Conserved Domains (2) summary

cd08337
Location:1 → 80

DED_c-FLIP_r1; Death Effector Domain, repeat 1, of cellular FLICE-Inhibitory Protein

cd08340
Location:91 → 171

DED_c-FLIP_r2; Death Effector Domain, repeat 2, of cellular FLICE-Inhibitory Protein
NM_001351593.2 → NP_001338522.1 CASP8 and FADD-like apoptosis regulator isoform 5

Status: REVIEWED

Description

Transcript Variant: This variant (14), as well as variants 6 and 15, encodes isoform 5.

Source sequence(s)

AC007283

Consensus CDS

CCDS56158.1

UniProtKB/TrEMBL

B4E361

Conserved Domains (2) summary

smart00115
Location:148 → 383

CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues

cd08340
Location:1 → 75

DED_c-FLIP_r2; Death Effector Domain, repeat 2, of cellular FLICE-Inhibitory Protein
NM_001351594.2 → NP_001338523.1 CASP8 and FADD-like apoptosis regulator isoform 5

Status: REVIEWED

Description

Transcript Variant: This variant (15), as well as variants 6 and 14, encodes isoform 5.

Source sequence(s)

AC007283

Consensus CDS

CCDS56158.1

UniProtKB/TrEMBL

B4E361

Conserved Domains (2) summary

smart00115
Location:148 → 383

CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues

cd08340
Location:1 → 75

DED_c-FLIP_r2; Death Effector Domain, repeat 2, of cellular FLICE-Inhibitory Protein
NM_003879.7 → NP_003870.4 CASP8 and FADD-like apoptosis regulator isoform 1

See identical proteins and their annotated locations for NP_003870.4

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents use of an alternate first exon and encodes the longest protein isoform (1). Variants 1 and 2 both encode the same isoform (1).

Source sequence(s)

AC007283

Consensus CDS

CCDS2337.1

UniProtKB/Swiss-Prot

B4DJE0, B7Z9F9, O14673, O14674, O14675, O15137, O15138, O15356, O15510, O15519, O43618, O43619, O43620, O60458, O60459, Q53TS6, Q54AF1, Q96TE4, Q9UEW1

UniProtKB/TrEMBL

A0A024R3Y4, A0A024R3Z7

Related

ENSP00000312455.2, ENST00000309955.8

Conserved Domains (3) summary

smart00115
Location:244 → 479

CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues

cd08337
Location:1 → 80

DED_c-FLIP_r1; Death Effector Domain, repeat 1, of cellular FLICE-Inhibitory Protein

cd08340
Location:91 → 171

DED_c-FLIP_r2; Death Effector Domain, repeat 2, of cellular FLICE-Inhibitory Protein