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dht D-hydantoinase/dihydropyrimidinase [ Pseudomonas aeruginosa PAO1 ]

Gene ID: 882285, updated on 6-Oct-2023

Summary

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Gene symbol
dht
Gene description
D-hydantoinase/dihydropyrimidinase
Locus tag
PA0441
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Pseudomonas aeruginosa PAO1 (strain: PAO1)
Lineage
Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas
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Genomic context

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Sequence:
NC_002516.2 (494816..496255, complement)

NC_002516.2Genomic Context describing neighboring genes Neighboring gene cytosine deaminase Neighboring gene cytosine permease Neighboring gene dihydropyrimidine dehydrogenase Neighboring gene oxidoreductase Neighboring gene hypothetical protein Neighboring gene transporter

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_002516.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Crystal structure of dihydropyrimidinase from Pseudomonas aeruginosa PAO1: Insights into the molecular basis of formation of a dimer. Tzeng CT, et al. Biochem Biophys Res Commun, 2016 Sep 23. PMID 27576201
  2. Crystal structures of monometallic dihydropyrimidinase and the human dihydroorotase domain K1556A mutant reveal no lysine carbamylation within the active site. Cheng JH, et al. Biochem Biophys Res Commun, 2018 Oct 28. PMID 30268498
  3. Pseudomonas Genome Database: facilitating user-friendly, comprehensive comparisons of microbial genomes. Winsor GL, et al. Nucleic Acids Res, 2009 Jan. PMID 18978025, Free PMC Article
  4. Defining the Pseudomonas aeruginosa SOS response and its role in the global response to the antibiotic ciprofloxacin. Cirz RT, et al. J Bacteriol, 2006 Oct. PMID 17015649, Free PMC Article
  5. Cystic fibrosis sputum supports growth and cues key aspects of Pseudomonas aeruginosa physiology. Palmer KL, et al. J Bacteriol, 2005 Aug. PMID 16030221, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. structural evidences indicated that post-translational carbamylated Lys was not required for Znalpha binding in PaDHPase and in huDHOase.
    Title: Crystal structures of monometallic dihydropyrimidinase and the human dihydroorotase domain K1556A mutant reveal no lysine carbamylation within the active site.
  2. Basing on sequence analysis and structural comparison of the C-terminal region and the dimer-dimer interface between P. aeruginosa dihydropyrimidinase and Thermus sp. dihydropyrimidinase, we propose a working model to explain why this enzyme cannot be a tetramer.
    Title: Crystal structure of dihydropyrimidinase from Pseudomonas aeruginosa PAO1: Insights into the molecular basis of formation of a dimer.
Submit: New GeneRIF Correction

General gene information

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Homology

General protein information

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Preferred Names
D-hydantoinase/dihydropyrimidinase
NP_249132.1
  • Product name confidence: class 2 (High similarity to functionally studied protein)

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_002516.2 Reference assembly

    Range
    494816..496255 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_249132.1 D-hydantoinase/dihydropyrimidinase [Pseudomonas aeruginosa PAO1]

    See identical proteins and their annotated locations for NP_249132.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A3M5EY41
    Conserved Domains (1) summary
    PRK08323
    Location:1 → 462
    PRK08323; phenylhydantoinase; Validated
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9I676.1

Gene LinkOut

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