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rocR DNA-binding response regulator RocR [ Pseudomonas aeruginosa PAO1 ]

Gene ID: 878871, updated on 11-Sep-2024

Summary

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Gene symbol
rocR
Gene description
DNA-binding response regulator RocR
Locus tag
PA3947
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Pseudomonas aeruginosa PAO1 (strain: PAO1)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas
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Genomic context

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Sequence:
NC_002516.2 (4426952..4428130, complement)

NC_002516.2Genomic Context describing neighboring genes Neighboring gene hypothetical protein Neighboring gene two-component sensor Neighboring gene two-component response regulator RocA1 Neighboring gene hypothetical protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_002516.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Expression, purification and preliminary crystallographic analysis of Pseudomonas aeruginosa RocR protein. Kotaka M, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2009 Oct 1. PMID 19851016, Free PMC Article
  2. The functional role of a conserved loop in EAL domain-based cyclic di-GMP-specific phosphodiesterase. Rao F, et al. J Bacteriol, 2009 Aug. PMID 19376848, Free PMC Article
  3. A novel two-component system controls the expression of Pseudomonas aeruginosa fimbrial cup genes. Kulasekara HD, et al. Mol Microbiol, 2005 Jan. PMID 15659157
  4. Analysis of Pseudomonas aeruginosa diguanylate cyclases and phosphodiesterases reveals a role for bis-(3'-5')-cyclic-GMP in virulence. Kulasakara H, et al. Proc Natl Acad Sci U S A, 2006 Feb 21. PMID 16477007, Free PMC Article
  5. Pseudomonas Genome Database: facilitating user-friendly, comprehensive comparisons of microbial genomes. Winsor GL, et al. Nucleic Acids Res, 2009 Jan. PMID 18978025, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The crystals belonged to space group P6(1)22 or P6(5)22, with unit-cell parameters a = 118.8, b = 118.8, c = 495.1 A, alpha = beta = 90, gamma = 120 degrees.
    Title: Expression, purification and preliminary crystallographic analysis of Pseudomonas aeruginosa RocR protein.
  2. Study found that the catalytic activity of the EAL domains of RocR from Pseudomonas aeruginosa was significantly altered by mutations in the loop 6 region.
    Title: The functional role of a conserved loop in EAL domain-based cyclic di-GMP-specific phosphodiesterase.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by PseudoCAP

Function Evidence Code Pubs
enables cyclic-guanylate-specific phosphodiesterase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within negative regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
DNA-binding response regulator RocR
NP_252636.1
  • class 1: Function experimentally demonstrated in P. aeruginosa

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_002516.2 Reference assembly

    Range
    4426952..4428130 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_252636.1 DNA-binding response regulator RocR [Pseudomonas aeruginosa PAO1]

    See identical proteins and their annotated locations for NP_252636.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    Q9HX69
    Conserved Domains (2) summary
    cd01948
    Location:145 → 384
    EAL; EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second ...
    cd17530
    Location:4 → 127
    REC_RocR; phosphoacceptor receiver (REC) domain of response regulator RocR
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9HX69.1

Gene LinkOut

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