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wspR two-component response regulator [ Pseudomonas aeruginosa PAO1 ]

Gene ID: 878337, updated on 24-Aug-2024

Summary

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Gene symbol
wspR
Gene description
two-component response regulator
Locus tag
PA3702
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Pseudomonas aeruginosa PAO1 (strain: PAO1)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas
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Genomic context

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Sequence:
NC_002516.2 (4143788..4144831, complement)

NC_002516.2Genomic Context describing neighboring genes Neighboring gene lysine--tRNA ligase Neighboring gene peptide chain release factor 1 Neighboring gene chemotaxis-specific methylesterase Neighboring gene chemotaxis sensor/effector fusion protein Neighboring gene hypothetical protein Neighboring gene biofilm formation methyltransferase WspC

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_002516.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Subcellular clustering of the phosphorylated WspR response regulator protein stimulates its diguanylate cyclase activity. Huangyutitham V, et al. mBio, 2013 May 7. PMID 23653447, Free PMC Article
  2. Subcellular location characteristics of the Pseudomonas aeruginosa GGDEF protein, WspR, indicate that it produces cyclic-di-GMP in response to growth on surfaces. Güvener ZT, et al. Mol Microbiol, 2007 Dec. PMID 18028314, Free PMC Article
  3. Phosphorylation-independent regulation of the diguanylate cyclase WspR. De N, et al. PLoS Biol, 2008 Mar 25. PMID 18366254, Free PMC Article
  4. Pseudomonas Genome Database: facilitating user-friendly, comprehensive comparisons of microbial genomes. Winsor GL, et al. Nucleic Acids Res, 2009 Jan. PMID 18978025, Free PMC Article
  5. Defining the Pseudomonas aeruginosa SOS response and its role in the global response to the antibiotic ciprofloxacin. Cirz RT, et al. J Bacteriol, 2006 Oct. PMID 17015649, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Cluster formation appears to be an intrinsic property of phosphorylated WspR (WspR-P).
    Title: Subcellular clustering of the phosphorylated WspR response regulator protein stimulates its diguanylate cyclase activity.
  2. Results show that WspR mutated at Asp70, its predicted site of phosphorylation, did not form clusters.
    Title: Subcellular location characteristics of the Pseudomonas aeruginosa GGDEF protein, WspR, indicate that it produces cyclic-di-GMP in response to growth on surfaces.
  3. The crystal structure of the diguanylate cyclase WspR, a conserved GGDEF domain-containing response regulator in Gram-negative bacteria, bound to c-di-GMP at an inhibitory site, is presented.
    Title: Phosphorylation-independent regulation of the diguanylate cyclase WspR.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by PseudoCAP

Function Evidence Code Pubs
enables diguanylate cyclase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables diguanylate cyclase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
two-component response regulator
NP_252391.1
  • 'Product name confidence: class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene)'

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_002516.2 Reference assembly

    Range
    4143788..4144831 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_252391.1 two-component response regulator [Pseudomonas aeruginosa PAO1]

    See identical proteins and their annotated locations for NP_252391.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A2R3IXM0
    Conserved Domains (1) summary
    COG3706
    Location:2 → 339
    PleD; Two-component response regulator, PleD family, consists of two REC domains and a diguanylate cyclase (GGDEF) domain [Signal transduction mechanisms, Transcription]
Nucleotide Protein
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Research Materials