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ampC beta-lactamase [ Pseudomonas aeruginosa PAO1 ]

Gene ID: 878149, updated on 11-Sep-2024

Summary

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Gene symbol
ampC
Gene description
beta-lactamase
Locus tag
PA4110
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Pseudomonas aeruginosa PAO1 (strain: PAO1)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas
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Genomic context

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Sequence:
NC_002516.2 (4594029..4595222)

NC_002516.2Genomic Context describing neighboring genes Neighboring gene hypothetical protein Neighboring gene transcriptional regulator AmpR Neighboring gene hypothetical protein Neighboring gene sensor/response regulator hybrid protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_002516.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Molecular Basis of AmpC β-Lactamase Induction by Avibactam in Pseudomonas aeruginosa: PBP Occupancy, Live Cell Binding Dynamics and Impact on Resistant Clinical Isolates Harboring PDC-X Variants. López-Argüello S, et al. Int J Mol Sci, 2021 Mar 17. PMID 33802668, Free PMC Article
  2. Investigation of the Pseudomonas aeruginosa ampR gene and its role at the chromosomal ampC beta-lactamase promoter. Lodge J, et al. FEMS Microbiol Lett, 1993 Aug 1. PMID 8405939
  3. Mutations in β-Lactamase AmpC Increase Resistance of Pseudomonas aeruginosa Isolates to Antipseudomonal Cephalosporins. Berrazeg M, et al. Antimicrob Agents Chemother, 2015 Oct. PMID 26248364, Free PMC Article
  4. Presence of blaPER-1 and blaVEB-1 beta-lactamase genes among isolates of Pseudomonas aeruginosa from South West of Iran. Davodian E, et al. J Epidemiol Glob Health, 2016 Sep. PMID 26944896, Free PMC Article
  5. Elucidation of Mechanisms of Ceftazidime Resistance among Clinical Isolates of Pseudomonas aeruginosa by Using Genomic Data. Kos VN, et al. Antimicrob Agents Chemother, 2016 Jun. PMID 27067331, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Interplay of OpdP Porin and Chromosomal Carbapenemases in the Determination of Carbapenem Resistance/Susceptibility in Pseudomonas aeruginosa.
    Title: Interplay of OpdP Porin and Chromosomal Carbapenemases in the Determination of Carbapenem Resistance/Susceptibility in Pseudomonas aeruginosa.
  2. Molecular Basis of AmpC beta-Lactamase Induction by Avibactam in Pseudomonas aeruginosa: PBP Occupancy, Live Cell Binding Dynamics and Impact on Resistant Clinical Isolates Harboring PDC-X Variants.
    Title: Molecular Basis of AmpC β-Lactamase Induction by Avibactam in Pseudomonas aeruginosa: PBP Occupancy, Live Cell Binding Dynamics and Impact on Resistant Clinical Isolates Harboring PDC-X Variants.
  3. Development of a Chimeric Vaccine Against Pseudomonas aeruginosa Based on the Th17-Stimulating Epitopes of PcrV and AmpC.
    Title: Development of a Chimeric Vaccine Against Pseudomonas aeruginosa Based on the Th17-Stimulating Epitopes of PcrV and AmpC.
  4. Among several acquired beta-lactamase enzymes, the blaPER-1 and blaVEB-1, although produced less frequently, have clinical importance because of conferring resistance to oxyimino beta-lactams.
    Title: Presence of blaPER-1 and blaVEB-1 beta-lactamase genes among isolates of Pseudomonas aeruginosa from South West of Iran.
  5. Changes have been identified within AmpD responsible for derepression of ampC and conferring ceftazidime resistance.
    Title: Elucidation of Mechanisms of Ceftazidime Resistance among Clinical Isolates of Pseudomonas aeruginosa by Using Genomic Data.
  6. Pseudomonas aeruginosa is able to adapt to efficacious beta-lactams, including the newer cephalosporin ceftolozane, through a variety of mutations affecting its intrinsic beta-lactamase, AmpC.
    Title: Mutations in β-Lactamase AmpC Increase Resistance of Pseudomonas aeruginosa Isolates to Antipseudomonal Cephalosporins.
  7. Overexpression of the ampC gene was observed in carbapenem-resistant P. aeruginosa isolates, but no carbapenem-susceptible isolates overexpressed the ampC gene.
    Title: OprD mutations and inactivation, expression of efflux pumps and AmpC, and metallo-β-lactamases in carbapenem-resistant Pseudomonas aeruginosa isolates from South Korea.
  8. The regulatory repertoire of Pseudomonas aeruginosa AmpC ss-lactamase regulator AmpR includes virulence genes
    Title: The regulatory repertoire of Pseudomonas aeruginosa AmpC ß-lactamase regulator AmpR includes virulence genes.
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General gene information

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Homology

Gene Ontology Provided by PseudoCAP

Process Evidence Code Pubs
acts_upstream_of_or_within regulation of beta-lactamase activity IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within response to stimulus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
beta-lactamase
NP_252799.1
  • Product name confidence: class 1 (Function experimentally demonstrated in P. aeruginosa)

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_002516.2 Reference assembly

    Range
    4594029..4595222
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_252799.1 beta-lactamase [Pseudomonas aeruginosa PAO1]

    See identical proteins and their annotated locations for NP_252799.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    Q8RL89
    Conserved Domains (1) summary
    PRK11289
    Location:4 → 388
    ampC; beta-lactamase/D-alanine carboxypeptidase; Provisional
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P24735.2

Gene LinkOut

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Molecular Biology Databases
Research Materials