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ptxR HTH-type transcriptional regulator PtxR [ Pseudomonas aeruginosa PAO1 ]

Gene ID: 878030, updated on 18-Sep-2024

Summary

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Gene symbol
ptxR
Gene description
HTH-type transcriptional regulator PtxR
Locus tag
PA2258
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Pseudomonas aeruginosa PAO1 (strain: PAO1)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas
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Genomic context

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Sequence:
NC_002516.2 (2486355..2487293, complement)

NC_002516.2Genomic Context describing neighboring genes Neighboring gene paerucumarin biosynthesis protein PvcB Neighboring gene paerucumarin biosynthesis protein PvcC Neighboring gene paerucumarin biosynthesis protein PvcD Neighboring gene transcriptional regulator PtxS Neighboring gene hypothetical protein Neighboring gene 2-ketogluconate kinase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_002516.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Isolation and characterization of a Pseudomonas aeruginosa gene, ptxR, which positively regulates exotoxin A production. Hamood AN, et al. Mol Microbiol, 1996 Jul. PMID 8843437
  2. PtxR modulates the expression of QS-controlled virulence factors in the Pseudomonas aeruginosa strain PAO1. Carty NL, et al. Mol Microbiol, 2006 Aug. PMID 16803594
  3. Transcriptional analysis of the Pseudomonas aeruginosa toxA regulatory gene ptxR. Colmer-Hamood JA, et al. Can J Microbiol, 2006 Apr. PMID 16699585
  4. Regulation of Pseudomonas aeruginosa ptxR by Vfr. Ferrell E, et al. Microbiology (Reading), 2008 Feb. PMID 18227247
  5. Genes for carbon metabolism and the ToxA virulence factor in Pseudomonas aeruginosa are regulated through molecular interactions of PtxR and PtxS. Daddaoua A, et al. PLoS One, 2012. PMID 22844393, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PtxS modulates PtxR activity in response to 2-ketogluconate by complex formation in solution in the case of the P(toxA) promoter, or via the formation of a DNA loop as in the regulation of gluconate catabolic genes
    Title: Genes for carbon metabolism and the ToxA virulence factor in Pseudomonas aeruginosa are regulated through molecular interactions of PtxR and PtxS.
  2. This study showed within the ptxR upstream region, a 25 bp sequence to which Vfr specifically binds.
    Title: Regulation of Pseudomonas aeruginosa ptxR by Vfr.
  3. Results suggest that different segments of the ptxR upstream region play specific roles in ptxR expression and their deletion caused variations in the level as well as the pattern of ptxR expression.
    Title: Transcriptional analysis of the Pseudomonas aeruginosa toxA regulatory gene ptxR.
  4. PtxR negatively regulates the expression of the virulence factors, such as rhamnolipid and pyocyanin genes
    Title: PtxR modulates the expression of QS-controlled virulence factors in the Pseudomonas aeruginosa strain PAO1.
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General gene information

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Homology

Gene Ontology Provided by PseudoCAP

Function Evidence Code Pubs
enables NAD+-protein poly-ADP-ribosyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within negative regulation of secondary metabolite biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within positive regulation of proteolysis IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
HTH-type transcriptional regulator PtxR
NP_250948.1
  • Product name confidence: class 1 (Function experimentally demonstrated in P. aeruginosa)

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_002516.2 Reference assembly

    Range
    2486355..2487293 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_250948.1 HTH-type transcriptional regulator PtxR [Pseudomonas aeruginosa PAO1]

    See identical proteins and their annotated locations for NP_250948.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    O30374
    Conserved Domains (2) summary
    cd08422
    Location:101 → 297
    PBP2_CrgA_like; The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain
    pfam00126
    Location:13 → 56
    HTH_1; Bacterial regulatory helix-turn-helix protein, lysR family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P72131.1

Gene LinkOut

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Molecular Biology Databases