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toxA exotoxin A [ Pseudomonas aeruginosa PAO1 ]

Gene ID: 877850, updated on 11-Sep-2024

Summary

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Gene symbol
toxA
Gene description
exotoxin A
Locus tag
PA1148
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Pseudomonas aeruginosa PAO1 (strain: PAO1)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas
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Genomic context

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Sequence:
NC_002516.2 (1240584..1242500, complement)

NC_002516.2Genomic Context describing neighboring genes Neighboring gene iron-containing alcohol dehydrogenase Neighboring gene amino acid permease Neighboring gene hypothetical protein Neighboring gene pyocin-S2

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_002516.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. [Production and properties evaluation of monoclonal antibodies against Pseudomonas aeruginosa exotoxin A]. Soldatenkova AV, et al. Zh Mikrobiol Epidemiol Immunobiol, 2014 Jan-Feb. PMID 24738291
  2. Virulence of an exotoxin A-deficient strain of Pseudomonas aeruginosa toward the silkworm, Bombyx mori. Chieda Y, et al. Microb Pathog, 2011 Dec. PMID 21945328
  3. Norepinephrine represses the expression of toxA and the siderophore genes in Pseudomonas aeruginosa. Li W, et al. FEMS Microbiol Lett, 2009 Oct. PMID 19686346, Free PMC Article
  4. Increasing the antitumor effect of an EpCAM-targeting fusion toxin by facile click PEGylation. Simon M, et al. Mol Cancer Ther, 2014 Feb. PMID 24184633
  5. A novel combination immunotherapy for cancer by IL-13Rα2-targeted DNA vaccine and immunotoxin in murine tumor models. Nakashima H, et al. J Immunol, 2011 Nov 15. PMID 22013118, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Our results show that the chimeric EGFETA toxin is extremely effective against EGFRpositive cancers and raises the potential to further develop this chimera for use in targeting EGFRpositive tumours resistant to monoclonal antibodies.
    Title: EGF ligand fused to truncated Pseudomonas aeruginosa exotoxin A specifically targets and inhibits EGFR‑positive cancer cells.
  2. Studied the presence of virulence genes (B-type flagellin [fliC], exotoxin A [toxA] and phzS) using molecular typing among isolates of Pseudomonas aeruginosa cultured from specimens from diabetic foot. Found fliC, toxA and phzS genes can play important roles in tissue penetration, tissue damage and survival.
    Title: Virulence genes fliC, toxA and phzS are common among Pseudomonas aeruginosa isolates from diabetic foot infections.
  3. Data indicate that anti-EpCAM fusion toxin for tumor targeting by click PEGylation suggest new perspectives for effective cancer-related therapy.
    Title: Increasing the antitumor effect of an EpCAM-targeting fusion toxin by facile click PEGylation.
  4. Use of the antibodies produced for testing toxigenicity of P. aeruginosa strains as well as detection of anatoxin in the technological process of production of prophylaxis preparations based on exotoxin A is expected.
    Title: [Production and properties evaluation of monoclonal antibodies against Pseudomonas aeruginosa exotoxin A].
  5. The highest level was observed for IL-1 and IL-6 after administration of recombinant proteins OprL, OprF, OprF-1, aTox.
    Title: [Pseudomonas aeruginosa recombinant proteins: effect on mice cytokine profile].
  6. PtxS modulates PtxR activity in response to 2-ketogluconate by complex formation in solution in the case of the P(toxA) promoter, or via the formation of a DNA loop as in the regulation of gluconate catabolic genes
    Title: Genes for carbon metabolism and the ToxA virulence factor in Pseudomonas aeruginosa are regulated through molecular interactions of PtxR and PtxS.
  7. ATF-7 and ZIP-2 transcription factors are required for preventing ToxA-mediated lethality.
    Title: Host translational inhibition by Pseudomonas aeruginosa Exotoxin A Triggers an immune response in Caenorhabditis elegans.
  8. These results indicated that exotoxin A acts as a virulence factor in Bombyx mori and that other virulence factor(s) are involved during the late stages of infection.
    Title: Virulence of an exotoxin A-deficient strain of Pseudomonas aeruginosa toward the silkworm, Bombyx mori.
  9. When combined with IL-13Ralpha2 DNA cancer vaccine, Pseudomonas aeruginosa exotoxin A mediates synergistic antitumor effects on tumor growth and metastasis in established murine breast carcinoma and sarcoma tumor models.
    Title: A novel combination immunotherapy for cancer by IL-13Rα2-targeted DNA vaccine and immunotoxin in murine tumor models.
  10. Norepinephrine represses the expression of toxA and the siderophore genes.
    Title: Norepinephrine represses the expression of toxA and the siderophore genes in Pseudomonas aeruginosa.
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General gene information

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Homology

General protein information

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Preferred Names
exotoxin A
NP_249839.1
  • Product name confidence: class 1 (Function experimentally demonstrated in P. aeruginosa)

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_002516.2 Reference assembly

    Range
    1240584..1242500 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_249839.1 exotoxin A [Pseudomonas aeruginosa PAO1]

    See identical proteins and their annotated locations for NP_249839.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A8B1P345
    Conserved Domains (3) summary
    pfam09101
    Location:27 → 275
    Exotox-A_bind; Exotoxin A binding
    pfam09009
    Location:447 → 618
    Exotox-A_cataly; Exotoxin A catalytic
    pfam09102
    Location:277 → 407
    Exotox-A_target; Exotoxin A, targeting
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P11439.2

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Molecular Biology Databases
Research Materials