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pchP phosphorylcholine phosphatase [ Pseudomonas aeruginosa PAO1 ]

Gene ID: 877730, updated on 11-Sep-2024

Summary

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Gene symbol
pchP
Gene description
phosphorylcholine phosphatase
Locus tag
PA5292
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Pseudomonas aeruginosa PAO1 (strain: PAO1)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas
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Genomic context

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Sequence:
NC_002516.2 (5957208..5958257, complement)

NC_002516.2Genomic Context describing neighboring genes Neighboring gene hypothetical protein Neighboring gene choline transporter Neighboring gene transcriptional regulator Neighboring gene multidrug efflux protein NorA Neighboring gene hypothetical protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_002516.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The structural domains of Pseudomonas aeruginosa phosphorylcholine phosphatase cooperate in substrate hydrolysis: 3D structure and enzymatic mechanism. Infantes L, et al. J Mol Biol, 2012 Nov 2. PMID 22922065
  2. Site-directed mutations and kinetic studies show key residues involved in alkylammonium interactions and reveal two sites for phosphorylcholine in Pseudomonas aeruginosa phosphorylcholine phosphatase. Beassoni PR, et al. Biochim Biophys Acta, 2011 Jul. PMID 21515416
  3. Transition from octahedral to tetrahedral geometry causes the activation or inhibition by Znf2+ of Pseudomonas aeruginosa phosphorylcholine phosphatase. Otero LH, et al. Biometals, 2010 Apr. PMID 20135339
  4. Identification, cloning, and expression of Pseudomonas aeruginosa phosphorylcholine phosphatase gene. Massimelli MJ, et al. Curr Microbiol, 2005 May. PMID 15886911
  5. Choline catabolism, σ⁵⁴ factor and NtrC are required for the full expression of the Pseudomonas aeruginosa phosphorylcholine phosphatase gene. Massimelli MJ, et al. Microbiol Res, 2011 Jul 20. PMID 20869215

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The structural comparison of PchP with other phosphatases of the haloacid dehalogenase family provides a three-dimensional picture of the conserved catalytic cycle and the structural basis for the recognition of the diverse substrate molecules.
    Title: The structural domains of Pseudomonas aeruginosa phosphorylcholine phosphatase cooperate in substrate hydrolysis: 3D structure and enzymatic mechanism.
  2. These data demonstrate that choline catabolism and NtrC (nitrogen regulatory protein) are necessary for the full expression of pchP and is partially dependent on sigma(54) factor.
    Title: Choline catabolism, σ⁵⁴ factor and NtrC are required for the full expression of the Pseudomonas aeruginosa phosphorylcholine phosphatase gene.
  3. Studies suggest that that two sites, one catalytic and one inhibitory, are present in PchP and that they are adjacent and share residues.
    Title: Site-directed mutations and kinetic studies show key residues involved in alkylammonium interactions and reveal two sites for phosphorylcholine in Pseudomonas aeruginosa phosphorylcholine phosphatase.
  4. Data suggest that the inhibition of phosphorylcholine phosphatase produced by Zn(2+) at pH 7.4 reflect a change from octahedral to tetrahedral coordination geometry, which is produced by hydrolysis of the [Zn(2+)L(2)(-1)L(2)(0) (H(2)O)(2)] complex.
    Title: Transition from octahedral to tetrahedral geometry causes the activation or inhibition by Znf2+ of Pseudomonas aeruginosa phosphorylcholine phosphatase.
  5. GbdR is the primary regulator of plcH and pchP expression in phsophatidylcholine-rich environments, such as the lung
    Title: GbdR regulates Pseudomonas aeruginosa plcH and pchP transcription in response to choline catabolites.
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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

General protein information

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Preferred Names
phosphorylcholine phosphatase
NP_253979.1
  • Product name confidence: class 1 (Function experimentally demonstrated in P. aeruginosa)

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_002516.2 Reference assembly

    Range
    5957208..5958257 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_253979.1 phosphorylcholine phosphatase [Pseudomonas aeruginosa PAO1]

    See identical proteins and their annotated locations for NP_253979.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A3M5DRP7
    Conserved Domains (1) summary
    cl21460
    Location:50 → 228
    HAD_like; Haloacid Dehalogenase-like Hydrolases
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9HTR2.1

Gene LinkOut

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