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GBF1 golgi brefeldin A resistant guanine nucleotide exchange factor 1 [ Homo sapiens (human) ]

Gene ID: 8729, updated on 5-May-2024

Summary

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Official Symbol
GBF1provided by HGNC
Official Full Name
golgi brefeldin A resistant guanine nucleotide exchange factor 1provided by HGNC
Primary source
HGNC:HGNC:4181
See related
Ensembl:ENSG00000107862 MIM:603698; AllianceGenome:HGNC:4181
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CMT2GG; CMTDI2; CMTDIA; ARF1GEF
Summary
This gene encodes a member of the Sec7 domain family. The encoded protein is a guanine nucleotide exchange factor that regulates the recruitment of proteins to membranes by mediating GDP to GTP exchange. The encoded protein is localized to the Golgi apparatus and plays a role in vesicular trafficking by activating ADP ribosylation factor 1. The encoded protein has also been identified as an important host factor for viral replication. Multiple transcript variants have been observed for this gene. [provided by RefSeq, Dec 2010]
Expression
Ubiquitous expression in testis (RPKM 18.0), brain (RPKM 12.4) and 25 other tissues See more
Orthologs
mouse all
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Genomic context

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Location:
10q24.32
Exon count:
43
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (102230643..102382896)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (103115630..103267847)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (103990400..104142653)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr10:103911632-103912831 Neighboring gene nucleolar and coiled-body phosphoprotein 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2751 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:103989615-103989783 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2752 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2753 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2754 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3925 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3926 Neighboring gene ELOVL fatty acid elongase 3 Neighboring gene paired like homeodomain 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:104029238-104029738 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:104029739-104030239 Neighboring gene Sharpr-MPRA regulatory region 13217 Neighboring gene Sharpr-MPRA regulatory region 15234 Neighboring gene uncharacterized LOC107984263 Neighboring gene MPRA-validated peak1080 silencer Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:104147078-104147638 Neighboring gene NANOG hESC enhancer GRCh37_chr10:104151284-104151791 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr10:104151792-104152298 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2755 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3927 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3928 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3929 Neighboring gene Sharpr-MPRA regulatory region 13585 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2756 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:104160632-104161328 Neighboring gene Sharpr-MPRA regulatory region 3575 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2757 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:104169870-104170552 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:104170553-104171234 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2758 Neighboring gene nuclear factor kappa B subunit 2 Neighboring gene pleckstrin and Sec7 domain containing

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. De Novo and Inherited Variants in GBF1 are Associated with Axonal Neuropathy Caused by Golgi Fragmentation. Mendoza-Ferreira N, et al. Am J Hum Genet, 2020 Oct 1. PMID 32937143, Free PMC Article
  2. Role of the Guanine Nucleotide Exchange Factor GBF1 in the Replication of RNA Viruses. Martínez JL, et al. Viruses, 2020 Jun 24. PMID 32599855, Free PMC Article
  3. Quantitative Proteomics of Uukuniemi Virus-host Cell Interactions Reveals GBF1 as Proviral Host Factor for Phleboviruses. Uckeley ZM, et al. Mol Cell Proteomics, 2019 Dec. PMID 31570497, Free PMC Article
  4. A Redundant Mechanism of Recruitment Underlies the Remarkable Plasticity of the Requirement of Poliovirus Replication for the Cellular ArfGEF GBF1. Viktorova EG, et al. J Virol, 2019 Nov 1. PMID 31375590, Free PMC Article
  5. The Guanine Nucleotide Exchange Factor GBF1 Participates in Rotavirus Replication. Martínez JL, et al. J Virol, 2019 Oct 1. PMID 31270230, Free PMC Article

See all (160) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Viral protein engagement of GBF1 induces host cell vulnerability through synthetic lethality.
    Title: Viral protein engagement of GBF1 induces host cell vulnerability through synthetic lethality.
  2. Src activates retrograde membrane traffic through phosphorylation of GBF1.
    Title: Src activates retrograde membrane traffic through phosphorylation of GBF1.
  3. Modeling the dynamic behaviors of the COPI vesicle formation regulators, the small GTPase Arf1 and its activating Sec7 guanine nucleotide exchange factor GBF1 on Golgi membranes.
    Title: Modeling the dynamic behaviors of the COPI vesicle formation regulators, the small GTPase Arf1 and its activating Sec7 guanine nucleotide exchange factor GBF1 on Golgi membranes.
  4. SON DNA-binding protein mediates macrophage autophagy and responses to intracellular infection.
    Title: SON DNA-binding protein mediates macrophage autophagy and responses to intracellular infection.
  5. SNPs in SNCA, MCCC1, DLG2, GBF1 and MBNL2 are associated with Parkinson's disease in southern Chinese population.
    Title: SNPs in SNCA, MCCC1, DLG2, GBF1 and MBNL2 are associated with Parkinson's disease in southern Chinese population.
  6. Class II Arfs require a brefeldin-A-sensitive factor for Golgi association.
    Title: Class II Arfs require a brefeldin-A-sensitive factor for Golgi association.
  7. Role of the Guanine Nucleotide Exchange Factor GBF1 in the Replication of RNA Viruses.
    Title: Role of the Guanine Nucleotide Exchange Factor GBF1 in the Replication of RNA Viruses.
  8. De Novo and Inherited Variants in GBF1 are Associated with Axonal Neuropathy Caused by Golgi Fragmentation.
    Title: De Novo and Inherited Variants in GBF1 are Associated with Axonal Neuropathy Caused by Golgi Fragmentation.
  9. Rab18 plays a role upstream of the cytosolic lipolytic enzyme adipose triglyceride lipase (ATGL) and that recruitment of ATGL by Rab18 is mediated by elements of the Arf/GBF1 machinery. We find that Arf4-GFP is accumulated on the subset of lipid droplets associated with Rab18.
    Title: Rab18 regulates lipolysis via Arf/GBF1 and adipose triglyceride lipase.
  10. GBF1 is required for the life cycle of positive strand RNA viruses
    Title: Quantitative Proteomics of Uukuniemi Virus-host Cell Interactions Reveals GBF1 as Proviral Host Factor for Phleboviruses.
Submit: New GeneRIF Correction See all GeneRIFs (64)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Charcot-Marie-Tooth Disease, axonal, type 2GG
MedGen: C5561933 OMIM: 606483 GeneReviews: Not available
not available

EBI GWAS Catalog

Description
Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ21263, FLJ21500, KIAA0248, MGC134877, MGC134878

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity TAS
Traceable Author Statement
more info
  
enables phosphatidylinositol-3,4,5-trisphosphate binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphatidylinositol-3,5-bisphosphate binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in COPI coating of Golgi vesicle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in Golgi disassembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in Golgi organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in Golgi to endosome transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell activation involved in immune response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cellular response to virus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cilium assembly TAS
Traceable Author Statement
more info
  
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport TAS
Traceable Author Statement
more info
  
involved_in endoplasmic reticulum-Golgi intermediate compartment organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in establishment of monopolar cell polarity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in neutrophil chemotaxis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in post-Golgi vesicle-mediated transport TAS
Traceable Author Statement
more info
  
involved_in protein localization to Golgi apparatus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein localization to endoplasmic reticulum exit site IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein localization to endoplasmic reticulum tubular network IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in reactive oxygen species biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of ARF protein signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of protein localization to cell surface IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in retrograde transport, endosome to Golgi IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
  
located_in Golgi membrane TAS
Traceable Author Statement
more info
  
located_in cell leading edge IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cis-Golgi network IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in endoplasmic reticulum-Golgi intermediate compartment IDA
Inferred from Direct Assay
more info
 PubMed 
located_in lipid droplet IEA
Inferred from Electronic Annotation
more info
  
located_in membrane HDA PubMed 
located_in trans-Golgi network IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1
Names
BFA-resistant GEF 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001199378.2 → NP_001186307.1  Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses multiple alternate in-frame splice sites in the coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AL121928, AL160011, AL356420
    Consensus CDS
    CCDS91330.1
    UniProtKB/TrEMBL
    A0A7I2YQM2
    Related
    ENSP00000503428.1, ENST00000677240.1
    Conserved Domains (3) summary
    PHA03247
    Location:1791 → 1854
    PHA03247; large tegument protein UL36; Provisional
    COG5307
    Location:400 → 1003
    COG5307; Guanine-nucleotide exchange factor, contains Sec7 domain [General function prediction only]
    pfam01369
    Location:700 → 885
    Sec7; Sec7 domain

  2. NM_001199379.2 → NP_001186308.1  Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 isoform 3

    See identical proteins and their annotated locations for NP_001186308.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice site in the coding region, compared to variant 1. This results in a shorter protein (isoform 3), compared to isoform 1.
    Source sequence(s)
    AL121928, AL160011, AL356420
    Consensus CDS
    CCDS91333.1
    UniProtKB/TrEMBL
    A0A7I2YQM2
    Related
    ENSP00000503918.1, ENST00000676993.1
    Conserved Domains (3) summary
    PHA03247
    Location:1790 → 1853
    PHA03247; large tegument protein UL36; Provisional
    COG5307
    Location:399 → 1002
    COG5307; Guanine-nucleotide exchange factor, contains Sec7 domain [General function prediction only]
    pfam01369
    Location:699 → 884
    Sec7; Sec7 domain

  3. NM_001377137.1 → NP_001364066.1  Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) encodes the longest isoform (4).
    Source sequence(s)
    AL121928, AL160011, AL356420
    Consensus CDS
    CCDS91331.1
    UniProtKB/Swiss-Prot
    A0A7P0RGV0, Q149P0, Q149P1, Q5VXX3, Q92538, Q96CK6, Q96HZ3, Q9H473
    UniProtKB/TrEMBL
    A0A7I2YQM2
    Related
    ENSP00000359000.4, ENST00000369983.5
    Conserved Domains (3) summary
    PHA03247
    Location:1795 → 1858
    PHA03247; large tegument protein UL36; Provisional
    COG5307
    Location:400 → 1003
    COG5307; Guanine-nucleotide exchange factor, contains Sec7 domain [General function prediction only]
    pfam01369
    Location:700 → 885
    Sec7; Sec7 domain

  4. NM_001377138.1 → NP_001364067.1  Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AL121928, AL160011, AL356420
    Consensus CDS
    CCDS91332.1
    UniProtKB/TrEMBL
    A0A7I2V452, A0A7I2YQM2
    Related
    ENSP00000503565.1, ENST00000677439.1
    Conserved Domains (3) summary
    PHA03247
    Location:1778 → 1841
    PHA03247; large tegument protein UL36; Provisional
    COG5307
    Location:399 → 990
    COG5307; Guanine-nucleotide exchange factor, contains Sec7 domain [General function prediction only]
    pfam01369
    Location:687 → 872
    Sec7; Sec7 domain

  5. NM_001377139.1 → NP_001364068.1  Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AL121928, AL160011, AL356420
    Consensus CDS
    CCDS91336.1
    UniProtKB/TrEMBL
    A0A7I2V2L5, A0A7I2YQM2
    Related
    ENSP00000502966.1, ENST00000678351.1
    Conserved Domains (4) summary
    PLN03076
    Location:596 → 1080
    PLN03076; ARF guanine nucleotide exchange factor (ARF-GEF); Provisional
    PHA03247
    Location:1696 → 1759
    PHA03247; large tegument protein UL36; Provisional
    pfam01369
    Location:601 → 786
    Sec7; Sec7 domain
    pfam12783
    Location:400 → 468
    Sec7_N; Guanine nucleotide exchange factor in Golgi transport N-terminal

  6. NM_001377140.1 → NP_001364069.1  Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AL121928, AL160011, AL356420
    Consensus CDS
    CCDS91335.1
    UniProtKB/TrEMBL
    A0A7I2YQ65, A0A7I2YQM2
    Related
    ENSP00000502877.1, ENST00000677618.1
    Conserved Domains (4) summary
    PLN03076
    Location:596 → 1080
    PLN03076; ARF guanine nucleotide exchange factor (ARF-GEF); Provisional
    PHA03247
    Location:1692 → 1755
    PHA03247; large tegument protein UL36; Provisional
    pfam01369
    Location:601 → 786
    Sec7; Sec7 domain
    pfam12783
    Location:400 → 468
    Sec7_N; Guanine nucleotide exchange factor in Golgi transport N-terminal

  7. NM_001377141.1 → NP_001364070.1  Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8), as well as variant 1, encodes isoform 1.
    Source sequence(s)
    AL121928, AL160011, AL356420
    Consensus CDS
    CCDS7533.1
    UniProtKB/TrEMBL
    A0A7I2YQM2
    Related
    ENSP00000503207.1, ENST00000676513.1
    Conserved Domains (3) summary
    PHA03247
    Location:1794 → 1857
    PHA03247; large tegument protein UL36; Provisional
    COG5307
    Location:399 → 1002
    COG5307; Guanine-nucleotide exchange factor, contains Sec7 domain [General function prediction only]
    pfam01369
    Location:699 → 884
    Sec7; Sec7 domain

  8. NM_001391922.1 → NP_001378851.1  Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 isoform 8

    Status: REVIEWED

    Source sequence(s)
    AL121928, AL160011, AL356420
    UniProtKB/TrEMBL
    A0A7I2YQM2
    Conserved Domains (3) summary
    PHA03247
    Location:1823 → 1886
    PHA03247; large tegument protein UL36; Provisional
    COG5307
    Location:432 → 1035
    COG5307; Guanine-nucleotide exchange factor, contains Sec7 domain [General function prediction only]
    pfam01369
    Location:732 → 917
    Sec7; Sec7 domain

  9. NM_001391923.1 → NP_001378852.1  Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AL121928, AL160011, AL356420
    Consensus CDS
    CCDS91330.1
    UniProtKB/TrEMBL
    A0A7I2YQM2
    Conserved Domains (3) summary
    PHA03247
    Location:1791 → 1854
    PHA03247; large tegument protein UL36; Provisional
    COG5307
    Location:400 → 1003
    COG5307; Guanine-nucleotide exchange factor, contains Sec7 domain [General function prediction only]
    pfam01369
    Location:700 → 885
    Sec7; Sec7 domain

  10. NM_001391924.1 → NP_001378853.1  Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AL121928, AL160011, AL356420
    Consensus CDS
    CCDS91333.1
    UniProtKB/TrEMBL
    A0A7I2YQM2
    Conserved Domains (3) summary
    PHA03247
    Location:1790 → 1853
    PHA03247; large tegument protein UL36; Provisional
    COG5307
    Location:399 → 1002
    COG5307; Guanine-nucleotide exchange factor, contains Sec7 domain [General function prediction only]
    pfam01369
    Location:699 → 884
    Sec7; Sec7 domain

  11. NM_001391925.1 → NP_001378854.1  Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 isoform 9

    Status: REVIEWED

    Source sequence(s)
    AL121928, AL160011, AL356420
    UniProtKB/TrEMBL
    A0A7I2YQM2
    Conserved Domains (3) summary
    PHA03247
    Location:1782 → 1845
    PHA03247; large tegument protein UL36; Provisional
    COG5307
    Location:399 → 990
    COG5307; Guanine-nucleotide exchange factor, contains Sec7 domain [General function prediction only]
    pfam01369
    Location:687 → 872
    Sec7; Sec7 domain

  12. NM_001391926.1 → NP_001378855.1  Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 isoform 10

    Status: REVIEWED

    Source sequence(s)
    AL121928, AL160011, AL356420
    UniProtKB/TrEMBL
    A0A7I2YQM2
    Conserved Domains (3) summary
    PHA03247
    Location:1779 → 1842
    PHA03247; large tegument protein UL36; Provisional
    COG5307
    Location:400 → 991
    COG5307; Guanine-nucleotide exchange factor, contains Sec7 domain [General function prediction only]
    pfam01369
    Location:688 → 873
    Sec7; Sec7 domain

  13. NM_001391927.1 → NP_001378856.1  Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 isoform 11

    Status: REVIEWED

    Source sequence(s)
    AL121928, AL160011, AL356420
    UniProtKB/TrEMBL
    A0A7I2YQM2
    Conserved Domains (3) summary
    PHA03247
    Location:1747 → 1810
    PHA03247; large tegument protein UL36; Provisional
    COG5307
    Location:399 → 1002
    COG5307; Guanine-nucleotide exchange factor, contains Sec7 domain [General function prediction only]
    pfam01369
    Location:699 → 884
    Sec7; Sec7 domain

  14. NM_001391928.1 → NP_001378857.1  Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 isoform 12

    Status: REVIEWED

    Source sequence(s)
    AL121928, AL160011, AL356420
    UniProtKB/TrEMBL
    A0A7I2YQM2
    Conserved Domains (3) summary
    PHA03247
    Location:1743 → 1806
    PHA03247; large tegument protein UL36; Provisional
    COG5307
    Location:399 → 955
    COG5307; Guanine-nucleotide exchange factor, contains Sec7 domain [General function prediction only]
    pfam01369
    Location:652 → 837
    Sec7; Sec7 domain

  15. NM_001391929.1 → NP_001378858.1  Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 isoform 13

    Status: REVIEWED

    Source sequence(s)
    AL121928, AL160011, AL356420
    UniProtKB/TrEMBL
    A0A7I2YQM2
    Conserved Domains (4) summary
    PLN03076
    Location:1457 → 1531
    PLN03076; ARF guanine nucleotide exchange factor (ARF-GEF); Provisional
    PHA03247
    Location:1711 → 1774
    PHA03247; large tegument protein UL36; Provisional
    COG5307
    Location:399 → 959
    COG5307; Guanine-nucleotide exchange factor, contains Sec7 domain [General function prediction only]
    pfam01369
    Location:699 → 881
    Sec7; Sec7 domain

  16. NM_001391930.1 → NP_001378859.1  Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 isoform 14

    Status: REVIEWED

    Source sequence(s)
    AL121928, AL160011, AL356420
    Consensus CDS
    CCDS91334.1
    UniProtKB/TrEMBL
    A0A7I2V514, A0A7I2YQM2
    Related
    ENSP00000504214.1, ENST00000679238.1
    Conserved Domains (3) summary
    PHA03247
    Location:1696 → 1759
    PHA03247; large tegument protein UL36; Provisional
    COG5307
    Location:399 → 1002
    COG5307; Guanine-nucleotide exchange factor, contains Sec7 domain [General function prediction only]
    pfam01369
    Location:699 → 884
    Sec7; Sec7 domain

  17. NM_001391931.1 → NP_001378860.1  Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 isoform 15

    Status: REVIEWED

    Source sequence(s)
    AL121928, AL160011, AL356420
    UniProtKB/TrEMBL
    A0A7I2YQM2
    Conserved Domains (3) summary
    PHA03247
    Location:1664 → 1727
    PHA03247; large tegument protein UL36; Provisional
    COG5307
    Location:357 → 876
    COG5307; Guanine-nucleotide exchange factor, contains Sec7 domain [General function prediction only]
    pfam01369
    Location:573 → 758
    Sec7; Sec7 domain

  18. NM_001411003.1 → NP_001397932.1  Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 isoform 16

    Status: REVIEWED

    Source sequence(s)
    AL121928, AL160011, AL356420
    Consensus CDS
    CCDS91328.1
    UniProtKB/TrEMBL
    A0A669KB10
    Related
    ENSP00000501064.1, ENST00000674034.1

  19. NM_001411027.1 → NP_001397956.1  Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 isoform 17

    Status: REVIEWED

    Source sequence(s)
    AL121928, AL160011, AL356420
    Consensus CDS
    CCDS91329.1
    UniProtKB/TrEMBL
    A0A669KBG8
    Related
    ENSP00000501233.1, ENST00000673650.1

  20. NM_004193.3 → NP_004184.1  Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 isoform 1

    See identical proteins and their annotated locations for NP_004184.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AL121928, AL160011, AL356420
    Consensus CDS
    CCDS7533.1
    UniProtKB/TrEMBL
    A0A7I2YQM2
    Related
    ENSP00000503981.1, ENST00000676939.1
    Conserved Domains (3) summary
    PHA03247
    Location:1794 → 1857
    PHA03247; large tegument protein UL36; Provisional
    COG5307
    Location:399 → 1002
    COG5307; Guanine-nucleotide exchange factor, contains Sec7 domain [General function prediction only]
    pfam01369
    Location:699 → 884
    Sec7; Sec7 domain

RNA

  1. NR_165085.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL121928, AL160011, AL356420

  2. NR_165086.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL121928, AL160011, AL356420
    Related
    ENST00000677655.1

  3. NR_165087.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL121928, AL160011, AL356420
    Related
    ENST00000676682.1

  4. NR_165088.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL121928, AL160011, AL356420

  5. NR_165089.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL121928, AL160011, AL356420
    Related
    ENST00000679155.1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    102230643..102382896
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006718047.3 → XP_006718110.1  Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 isoform X1

    UniProtKB/TrEMBL
    A0A7I2YQM2
    Conserved Domains (2) summary
    pfam01369
    Location:733 → 918
    Sec7; Sec7 domain
    pfam12783
    Location:434 → 579
    Sec7_N; Guanine nucleotide exchange factor in Golgi transport N-terminal

  2. XM_006718049.3 → XP_006718112.1  Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 isoform X2

    UniProtKB/TrEMBL
    A0A7I2YQM2
    Conserved Domains (2) summary
    pfam01369
    Location:733 → 918
    Sec7; Sec7 domain
    pfam12783
    Location:434 → 579
    Sec7_N; Guanine nucleotide exchange factor in Golgi transport N-terminal

  3. XM_011540312.3 → XP_011538614.1  Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 isoform X5

    UniProtKB/TrEMBL
    A0A7I2YQM2
    Conserved Domains (2) summary
    pfam01369
    Location:686 → 871
    Sec7; Sec7 domain
    pfam12783
    Location:434 → 579
    Sec7_N; Guanine nucleotide exchange factor in Golgi transport N-terminal

  4. XM_047425970.1 → XP_047281926.1  Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 isoform X6

  5. XM_047425971.1 → XP_047281927.1  Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 isoform X7

  6. XM_017016861.3 → XP_016872350.1  Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 isoform X3

    UniProtKB/TrEMBL
    A0A7I2YQM2

  7. XM_047425969.1 → XP_047281925.1  Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 isoform X4

  8. XM_047425972.1 → XP_047281928.1  Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 isoform X8

  9. XM_047425974.1 → XP_047281930.1  Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 isoform X10

  10. XM_047425973.1 → XP_047281929.1  Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 isoform X9

  11. XM_011540313.3 → XP_011538615.1  Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 isoform X12

    UniProtKB/TrEMBL
    A0A7I2V4K2
    Conserved Domains (2) summary
    pfam01369
    Location:733 → 918
    Sec7; Sec7 domain
    pfam12783
    Location:434 → 579
    Sec7_N; Guanine nucleotide exchange factor in Golgi transport N-terminal

  12. XM_047425975.1 → XP_047281931.1  Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 isoform X11

  13. XM_011540314.3 → XP_011538616.1  Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 isoform X13

    Conserved Domains (3) summary
    PHA03247
    Location:1351 → 1414
    PHA03247; large tegument protein UL36; Provisional
    COG5307
    Location:40 → 559
    COG5307; Guanine-nucleotide exchange factor, contains Sec7 domain [General function prediction only]
    cd00171
    Location:256 → 441
    Sec7; Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the central domain of the guanine-nucleotide-exchange factors (GEFs) of the ADP-ribosylation factor family of small GTPases (ARFs) . It carries the exchange factor ...

RNA

  1. XR_001747253.3 RNA Sequence

    Related
    ENST00000676807.1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    103115630..103267847
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054367057.1 → XP_054223032.1  Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 isoform X1

  2. XM_054367058.1 → XP_054223033.1  Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 isoform X2

  3. XM_054367061.1 → XP_054223036.1  Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 isoform X5

  4. XM_054367062.1 → XP_054223037.1  Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 isoform X6

  5. XM_054367063.1 → XP_054223038.1  Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 isoform X7

  6. XM_054367059.1 → XP_054223034.1  Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 isoform X3

  7. XM_054367060.1 → XP_054223035.1  Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 isoform X4

  8. XM_054367064.1 → XP_054223039.1  Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 isoform X8

  9. XM_054367066.1 → XP_054223041.1  Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 isoform X10

  10. XM_054367065.1 → XP_054223040.1  Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 isoform X9

  11. XM_054367068.1 → XP_054223043.1  Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 isoform X12

  12. XM_054367067.1 → XP_054223042.1  Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 isoform X11

  13. XM_054367069.1 → XP_054223044.1  Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 isoform X13

RNA

  1. XR_008488306.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q92538.3 GenPept UniProtKB/Swiss-Prot:Q92538

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