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ABCC3 ATP binding cassette subfamily C member 3 [ Homo sapiens (human) ]

Gene ID: 8714, updated on 5-Mar-2024

Summary

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Official Symbol
ABCC3provided by HGNC
Official Full Name
ATP binding cassette subfamily C member 3provided by HGNC
Primary source
HGNC:HGNC:54
See related
Ensembl:ENSG00000108846 MIM:604323; AllianceGenome:HGNC:54
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MLP2; MRP3; ABC31; MOAT-D; cMOAT2; EST90757
Summary
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. The specific function of this protein has not yet been determined; however, this protein may play a role in the transport of biliary and intestinal excretion of organic anions. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]
Expression
Broad expression in adrenal (RPKM 32.2), stomach (RPKM 26.9) and 18 other tissues See more
Orthologs
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Genomic context

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See ABCC3 in Genome Data Viewer
Location:
17q21.33
Exon count:
31
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (50634881..50692253)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (51502046..51559449)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (48712242..48769614)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene CACNA1G antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12387 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8705 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:48639035-48639624 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:48646614-48647600 Neighboring gene calcium voltage-gated channel subunit alpha1 G Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:48670255-48671063 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:48673674-48674174 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:48686338-48686945 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:48702910-48703682 Neighboring gene uncharacterized LOC101927253 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8706 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr17:48715992-48717191 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:48717641-48718411 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr17:48738547-48739746 Neighboring gene Sharpr-MPRA regulatory region 5804 Neighboring gene ABCC3 (B) eExon liver enhancer Neighboring gene Sharpr-MPRA regulatory region 2031 Neighboring gene ankyrin repeat domain 40 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8707 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8708 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8709 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12388 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8710 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:48802297-48802796 Neighboring gene LUC7 like 3 pre-mRNA splicing factor

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Prevalence of ABCC3-1767G/A polymorphism among patients with antiretroviral-associated hepatotoxicity. Singh H, et al. Mol Genet Genomic Med, 2020 Jun. PMID 32212330, Free PMC Article
  2. ABCC3 is a novel target for the treatment of pancreatic cancer. Adamska A, et al. Adv Biol Regul, 2019 Aug. PMID 31053501
  3. Interindividual Differences in the Expression of ATP-Binding Cassette and Solute Carrier Family Transporters in Human Skin: DNA Methylation Regulates Transcriptional Activity of the Human ABCC3 Gene. Takechi T, et al. Drug Metab Dispos, 2018 May. PMID 29437875
  4. Role of the Drug Transporter ABCC3 in Breast Cancer Chemoresistance. Balaji SA, et al. PLoS One, 2016. PMID 27171227, Free PMC Article
  5. ABCC3 genetic variants are associated with postoperative morphine-induced respiratory depression and morphine pharmacokinetics in children. Chidambaran V, et al. Pharmacogenomics J, 2017 Mar. PMID 26810133, Free PMC Article

See all (124) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Association Study of SLCO1B3 and ABCC3 Genetic Variants in Gallstone Disease.
    Title: Association Study of SLCO1B3 and ABCC3 Genetic Variants in Gallstone Disease.
  2. The Role of TRIP6, ABCC3 and CPS1 Expression in Resistance of Ovarian Cancer to Taxanes.
    Title: The Role of TRIP6, ABCC3 and CPS1 Expression in Resistance of Ovarian Cancer to Taxanes.
  3. Effect of bile acids on the expression of MRP3 and MRP4: An In vitro study in HepG2 cell line.
    Title: Effect of bile acids on the expression of MRP3 and MRP4: An In vitro study in HepG2 cell line.
  4. CircABCC3 knockdown inhibits glioblastoma cell malignancy by regulating miR-770-5p/SOX2 axis through PI3K/AKT signaling pathway.
    Title: CircABCC3 knockdown inhibits glioblastoma cell malignancy by regulating miR-770-5p/SOX2 axis through PI3K/AKT signaling pathway.
  5. Prevalence of ABCC3-1767G/A polymorphism among patients with antiretroviral-associated hepatotoxicity.
    Title: Prevalence of ABCC3-1767G/A polymorphism among patients with antiretroviral-associated hepatotoxicity.
  6. ABCC3 is a novel target for the treatment of pancreatic cancer.
    Title: ABCC3 is a novel target for the treatment of pancreatic cancer.
  7. Low expression of MRP3 is associated with Hepatocellular Carcinoma and in Cholangiocarcinoma.
    Title: Immunohistochemical Assessment of the Expression of Biliary Transportation Proteins MRP2 and MRP3 in Hepatocellular Carcinoma and in Cholangiocarcinoma.
  8. OATPB1/B3 and MRP3 immunohistochemistry and signal intensity on hepatobiliary phase Gd-EOB-DTPA-enhanced MRI can help to stratify hepatocellular adenoma according to their risk of malignant transformation.
    Title: OATPB1/B3 and MRP3 expression in hepatocellular adenoma predicts Gd-EOB-DTPA uptake and correlates with risk of malignancy.
  9. The glucuronides of inactive androgens, androsterone glucuronide and etiocholanolone glucuronide were preferentially transported by MRP3, whereas the glucuronides of active androgens, Testosterone glucuronide and dihydrotestosterone glucuronide were mainly transported by MRP2 in liver.
    Title: Major glucuronide metabolites of testosterone are primarily transported by MRP2 and MRP3 in human liver, intestine and kidney.
  10. CGI may function as an enhancer of the transcription of ABCC3.
    Title: Interindividual Differences in the Expression of ATP-Binding Cassette and Solute Carrier Family Transporters in Human Skin: DNA Methylation Regulates Transcriptional Activity of the Human ABCC3 Gene.
Submit: New GeneRIF Correction See all GeneRIFs (89)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • DKFZp686E22157

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ABC-type bile acid transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables ABC-type bile acid transporter activity TAS
Traceable Author Statement
more info
  
enables ABC-type glutathione S-conjugate transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ABC-type transporter activity TAS
Traceable Author Statement
more info
  
enables ABC-type xenobiotic transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ABC-type xenobiotic transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables ATPase-coupled inorganic anion transmembrane transporter activity TAS
Traceable Author Statement
more info
  
enables ATPase-coupled transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ATPase-coupled transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ATPase-coupled transmembrane transporter activity TAS
Traceable Author Statement
more info
  
enables glucuronoside transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables icosanoid transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables xenobiotic transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in bile acid and bile salt transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in bile acid and bile salt transport TAS
Traceable Author Statement
more info
  
involved_in glucuronoside transport IEA
Inferred from Electronic Annotation
more info
  
involved_in leukotriene transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in monoatomic anion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transmembrane transport TAS
Traceable Author Statement
more info
  
involved_in transport across blood-brain barrier NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in xenobiotic metabolic process TAS
Traceable Author Statement
more info
  
involved_in xenobiotic transmembrane transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in xenobiotic transport IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in basal plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in basolateral plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
ATP-binding cassette sub-family C member 3
Names
ATP-binding cassette, sub-family C (CFTR/MRP), member 3
canalicular multispecific organic anion transporter 2
canicular multispecific organic anion transporter
multi-specific organic anion transporter D
multidrug resistance associated protein
multidrug resistance-associated protein 3
NP_001137542.1
NP_003777.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001144070.2 → NP_001137542.1  ATP-binding cassette sub-family C member 3 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks multiple 3' exons and has an alternate 3' sequence, as compared to variant 1. The resulting isoform (2) is much shorter and has a different C-terminus, as compared to isoform 1.
    Source sequence(s)
    BC046126, BC050370, BC058907
    Consensus CDS
    CCDS45739.1
    UniProtKB/TrEMBL
    Q86VN9
    Related
    ENSP00000395160.1, ENST00000427699.5
    Conserved Domains (1) summary
    cl00549
    Location:317 → 546
    ABC_membrane; ABC transporter transmembrane region

  2. NM_003786.4 → NP_003777.2  ATP-binding cassette sub-family C member 3 isoform 1

    See identical proteins and their annotated locations for NP_003777.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AB010887, AC005921, BC046126, BC137347
    Consensus CDS
    CCDS32681.1
    UniProtKB/Swiss-Prot
    B2RPA9, D3DTX9, O15438, O60265, O60922, O75621, O95078, O95289, O95290, Q86X85, Q9UN52
    UniProtKB/TrEMBL
    Q59H05
    Related
    ENSP00000285238.8, ENST00000285238.13
    Conserved Domains (1) summary
    cl26602
    Location:7 → 1526
    SunT; ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    50634881..50692253
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    51502046..51559449
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_020037.1: Suppressed sequence

    Description
    NM_020037.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.

  2. NM_020038.1: Suppressed sequence

    Description
    NM_020038.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O15438.3 GenPept UniProtKB/Swiss-Prot:O15438

Gene LinkOut

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