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CBLB Cbl proto-oncogene B [ Homo sapiens (human) ]

Gene ID: 868, updated on 3-Apr-2024

Summary

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Official Symbol
CBLBprovided by HGNC
Official Full Name
Cbl proto-oncogene Bprovided by HGNC
Primary source
HGNC:HGNC:1542
See related
Ensembl:ENSG00000114423 MIM:604491; AllianceGenome:HGNC:1542
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Cbl-b; RNF56; ADMIO3; Nbla00127
Summary
This gene encodes an E3 ubiquitin-protein ligase which promotes proteosome-mediated protein degradation by transferring ubiquitin from an E2 ubiquitin-conjugating enzyme to a substrate. The encoded protein is involved in the regulation of immune response by limiting T-cell receptor, B-cell receptor, and high affinity immunoglobulin epsilon receptor activation. Studies in mouse suggest that this gene is involved in antifungal host defense and that its inhibition leads to increased fungal killing. Manipulation of this gene may be beneficial in implementing immunotherapies for a variety of conditions, including cancer, autoimmune diseases, allergies, and infections. [provided by RefSeq, Sep 2017]
Expression
Ubiquitous expression in lymph node (RPKM 6.7), gall bladder (RPKM 4.7) and 25 other tissues See more
Orthologs
mouse all
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Genomic context

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See CBLB in Genome Data Viewer
Location:
3q13.11
Exon count:
32
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (105655461..105869449, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (108373636..108587751, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (105374305..105588245, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105374023 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr3:104875813-104876646 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:105015351-105015980 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20192 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:105072122-105072940 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14580 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14581 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20195 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:105087774-105088274 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:105088275-105088775 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr3:105120863-105122062 Neighboring gene uncharacterized LOC124906263 Neighboring gene activated leukocyte cell adhesion molecule Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:105222974-105223504 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:105223505-105224035 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr3:105438452-105439651 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14582 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20196 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20197 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20198 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14583 Neighboring gene uncharacterized LOC105374024 Neighboring gene uncharacterized LOC124909403

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. CBLB Deficiency in Human CD4(+) T Cells Results in Resistance to T Regulatory Suppression through Multiple Mechanisms. Song J, et al. J Immunol, 2022 Oct 1. PMID 36165179
  2. CBLB ablation with CRISPR/Cas9 enhances cytotoxicity of human placental stem cell-derived NK cells for cancer immunotherapy. Guo X, et al. J Immunother Cancer, 2021 Mar. PMID 33741730, Free PMC Article
  3. Cbl-b Is Upregulated and Plays a Negative Role in Activated Human NK Cells. Lu T, et al. J Immunol, 2021 Feb 15. PMID 33419766, Free PMC Article
  4. The effect of Casitas b-lineage lymphoma b on regulating T follicular helper in lupus nephritis. Wu J, et al. Eur Rev Med Pharmacol Sci, 2020 Apr. PMID 32373983
  5. Regulation of immune responses by E3 ubiquitin ligase Cbl-b. Tang R, et al. Cell Immunol, 2019 Jun. PMID 30442330, Free PMC Article

See all (192) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. [Circular RNA Cbl proto-oncogene B (circCBLB) inhibits proliferation, promotes apoptosis, and increases anti-inflammatory cytokine levels of fibroblast-like synoviocytes in rheumatoid arthritis].
    Title: [Circular RNA Cbl proto-oncogene B (circCBLB) inhibits proliferation, promotes apoptosis, and increases anti-inflammatory cytokine levels of fibroblast-like synoviocytes in rheumatoid arthritis].
  2. Cbl and Cbl-b independently regulate EGFR through distinct receptor interaction modes.
    Title: Cbl and Cbl-b independently regulate EGFR through distinct receptor interaction modes.
  3. Immune dysregulation caused by homozygous mutations in CBLB.
    Title: Immune dysregulation caused by homozygous mutations in CBLB.
  4. CBLB Deficiency in Human CD4(+) T Cells Results in Resistance to T Regulatory Suppression through Multiple Mechanisms.
    Title: CBLB Deficiency in Human CD4(+) T Cells Results in Resistance to T Regulatory Suppression through Multiple Mechanisms.
  5. miR-27b-3p Attenuates Muscle Atrophy by Targeting Cbl-b in Skeletal Muscles.
    Title: miR-27b-3p Attenuates Muscle Atrophy by Targeting Cbl-b in Skeletal Muscles.
  6. CBLB ablation with CRISPR/Cas9 enhances cytotoxicity of human placental stem cell-derived NK cells for cancer immunotherapy.
    Title: CBLB ablation with CRISPR/Cas9 enhances cytotoxicity of human placental stem cell-derived NK cells for cancer immunotherapy.
  7. Deletion of Cbl-b inhibits CD8(+) T-cell exhaustion and promotes CAR T-cell function.
    Title: Deletion of Cbl-b inhibits CD8(+) T-cell exhaustion and promotes CAR T-cell function.
  8. Cbl-b Is Upregulated and Plays a Negative Role in Activated Human NK Cells.
    Title: Cbl-b Is Upregulated and Plays a Negative Role in Activated Human NK Cells.
  9. The effect of Casitas b-lineage lymphoma b on regulating T follicular helper in lupus nephritis.
    Title: The effect of Casitas b-lineage lymphoma b on regulating T follicular helper in lupus nephritis.
  10. Cbl-b is essential for establishing the threshold for T cell activation and regulating peripheral T cell tolerance through various mechanisms. (Review)
    Title: Regulation of immune responses by E3 ubiquitin ligase Cbl-b.
Submit: New GeneRIF Correction See all GeneRIFs (68)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Autoimmune disease, multisystem, infantile-onset, 3
MedGen: C5830600 OMIM: 620430 GeneReviews: Not available
not available

EBI GWAS Catalog

Description
Variants within the immunoregulatory CBLB gene are associated with multiple sclerosis.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 downregulates the expression of Cbl proto-oncogene B, E3 ubiquitin protein ligase (CBLB) in human B cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ36865, FLJ41152, DKFZp779A0729, DKFZp779F1443, DKFZp686J10223

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables SH3 domain binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphotyrosine residue binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables receptor tyrosine kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables zinc ion binding TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in CD4-positive, alpha-beta T cell proliferation IEA
Inferred from Electronic Annotation
more info
  
involved_in NLS-bearing protein import into nucleus TAS
Traceable Author Statement
more info
 PubMed 
involved_in T cell anergy IEA
Inferred from Electronic Annotation
more info
  
involved_in T cell receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of CD4-positive, alpha-beta T cell proliferation IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of T cell receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of epidermal growth factor-activated receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of T cell anergy IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of protein catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in protein catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of platelet-derived growth factor receptor-alpha signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
  
is_active_in membrane raft IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
E3 ubiquitin-protein ligase CBL-B
Names
Cas-Br-M (murine) ecotropic retroviral transforming sequence b
Cbl proto-oncogene B, E3 ubiquitin protein ligase
Cbl proto-oncogene, E3 ubiquitin protein ligase B
RING finger protein 56
RING-type E3 ubiquitin transferase CBL-B
SH3-binding protein CBL-B
casitas B-lineage lymphoma proto-oncogene b
signal transduction protein CBL-B
NP_001308715.1
NP_001308717.1
NP_001308718.1
NP_001308719.1
NP_001308720.1
NP_001308722.1
NP_001308723.1
NP_001308724.1
NP_001308725.1
NP_001308726.1
NP_001308727.1
NP_001308728.1
NP_001308735.1
NP_001308736.1
NP_001308737.1
NP_001308740.1
NP_001308742.1
NP_001308745.1
NP_001308749.1
NP_001308751.1
NP_733762.2
XP_011511559.1
XP_011511561.2
XP_016862884.1
XP_016862885.1
XP_016862886.1
XP_016862887.1
XP_016862889.1
XP_047305068.1
XP_047305069.1
XP_047305070.1
XP_047305071.1
XP_047305072.1
XP_047305073.1
XP_047305074.1
XP_054204200.1
XP_054204201.1
XP_054204202.1
XP_054204203.1
XP_054204204.1
XP_054204205.1
XP_054204206.1
XP_054204207.1
XP_054204208.1
XP_054204209.1
XP_054204210.1
XP_054204211.1
XP_054204212.1
XP_054204213.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_055547.1 RefSeqGene

    Range
    5541..219092
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_1179

mRNA and Protein(s)

  1. NM_001321786.1 → NP_001308715.1  E3 ubiquitin-protein ligase CBL-B isoform a

    Status: REVIEWED

    Source sequence(s)
    AC016138, AC112485, AC126185
    UniProtKB/TrEMBL
    B8K284
    Conserved Domains (5) summary
    cd09920
    Location:276 → 372
    SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
    cd00162
    Location:401 → 443
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cd14392
    Location:959 → 999
    UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
    pfam02262
    Location:72 → 195
    Cbl_N; CBL proto-oncogene N-terminal domain 1
    pfam02761
    Location:199 → 282
    Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain

  2. NM_001321788.2 → NP_001308717.1  E3 ubiquitin-protein ligase CBL-B isoform b

    Status: REVIEWED

    Description
    Transcript Variant: Variants 2 and 3 encode the same isoform (b).
    Source sequence(s)
    AC016138, AC112485, AC126185
    Consensus CDS
    CCDS2948.1
    UniProtKB/Swiss-Prot
    A8K9S7, B7WNM4, Q13191, Q13192, Q13193, Q3LIC0, Q63Z43, Q8IVC5
    UniProtKB/TrEMBL
    B8K284
    Conserved Domains (5) summary
    cd09920
    Location:248 → 344
    SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
    cd14392
    Location:931 → 971
    UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
    cd16709
    Location:354 → 419
    RING-HC_Cbl-b; RING finger, HC subclass, found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
    pfam02262
    Location:44 → 165
    Cbl_N; CBL proto-oncogene N-terminal domain 1
    pfam02761
    Location:171 → 254
    Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain

  3. NM_001321789.1 → NP_001308718.1  E3 ubiquitin-protein ligase CBL-B isoform c

    Status: REVIEWED

    Source sequence(s)
    AC016138, AC112485, AC126185
    UniProtKB/TrEMBL
    B8K284
    Conserved Domains (5) summary
    cd09920
    Location:276 → 372
    SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
    cd00162
    Location:401 → 443
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cd14392
    Location:910 → 950
    UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
    pfam02262
    Location:72 → 195
    Cbl_N; CBL proto-oncogene N-terminal domain 1
    pfam02761
    Location:199 → 282
    Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain

  4. NM_001321790.2 → NP_001308719.1  E3 ubiquitin-protein ligase CBL-B isoform d

    Status: REVIEWED

    Source sequence(s)
    AC016138, AI221219, AK302533, AK316276
    UniProtKB/TrEMBL
    B4DYP3
    Conserved Domains (5) summary
    cd09920
    Location:270 → 366
    SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
    cd14392
    Location:909 → 949
    UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
    cd16709
    Location:376 → 441
    RING-HC_Cbl-b; RING finger, HC subclass, found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
    pfam02262
    Location:66 → 187
    Cbl_N; CBL proto-oncogene N-terminal domain 1
    pfam02761
    Location:193 → 276
    Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain

  5. NM_001321791.2 → NP_001308720.1  E3 ubiquitin-protein ligase CBL-B isoform e

    Status: REVIEWED

    Description
    Transcript Variant: Variants 6 and 7 encode the same isoform (e).
    Source sequence(s)
    AC016138, AC112485, AC126185
    UniProtKB/TrEMBL
    B4DYP3
    Conserved Domains (5) summary
    cd09920
    Location:248 → 344
    SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
    cd14392
    Location:887 → 927
    UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
    cd16709
    Location:354 → 419
    RING-HC_Cbl-b; RING finger, HC subclass, found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
    pfam02262
    Location:44 → 165
    Cbl_N; CBL proto-oncogene N-terminal domain 1
    pfam02761
    Location:171 → 254
    Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain

  6. NM_001321793.2 → NP_001308722.1  E3 ubiquitin-protein ligase CBL-B isoform e

    Status: REVIEWED

    Description
    Transcript Variant: Variants 6 and 7 encode the same isoform (e).
    Source sequence(s)
    AC016138, AC112485, AC126185
    UniProtKB/TrEMBL
    B4DYP3
    Conserved Domains (5) summary
    cd09920
    Location:248 → 344
    SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
    cd14392
    Location:887 → 927
    UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
    cd16709
    Location:354 → 419
    RING-HC_Cbl-b; RING finger, HC subclass, found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
    pfam02262
    Location:44 → 165
    Cbl_N; CBL proto-oncogene N-terminal domain 1
    pfam02761
    Location:171 → 254
    Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain

  7. NM_001321794.2 → NP_001308723.1  E3 ubiquitin-protein ligase CBL-B isoform f

    Status: REVIEWED

    Description
    Transcript Variant: Variants 8 and 9 encode the same isoform (f), which is the same length as isoform g but differs in the amino acid sequence.
    Source sequence(s)
    AC016138, AC112485, AC126185
    UniProtKB/TrEMBL
    B8K284
    Conserved Domains (5) summary
    cd09920
    Location:248 → 344
    SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
    cd14392
    Location:882 → 922
    UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
    cd16709
    Location:354 → 419
    RING-HC_Cbl-b; RING finger, HC subclass, found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
    pfam02262
    Location:44 → 165
    Cbl_N; CBL proto-oncogene N-terminal domain 1
    pfam02761
    Location:171 → 254
    Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain

  8. NM_001321795.2 → NP_001308724.1  E3 ubiquitin-protein ligase CBL-B isoform f

    Status: REVIEWED

    Description
    Transcript Variant: Variants 8 and 9 encode the same isoform (f), which is the same length as isoform g but differs in the amino acid sequence.
    Source sequence(s)
    AC016138, AC112485, AC126185
    UniProtKB/TrEMBL
    B8K284
    Conserved Domains (5) summary
    cd09920
    Location:248 → 344
    SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
    cd14392
    Location:882 → 922
    UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
    cd16709
    Location:354 → 419
    RING-HC_Cbl-b; RING finger, HC subclass, found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
    pfam02262
    Location:44 → 165
    Cbl_N; CBL proto-oncogene N-terminal domain 1
    pfam02761
    Location:171 → 254
    Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain

  9. NM_001321796.2 → NP_001308725.1  E3 ubiquitin-protein ligase CBL-B isoform g

    Status: REVIEWED

    Description
    Transcript Variant: Isoform g is the same length as isoform f but differs in the amino acid sequence.
    Source sequence(s)
    AC016138, AC112485
    UniProtKB/TrEMBL
    B8K284
    Conserved Domains (5) summary
    cd09920
    Location:199 → 295
    SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
    cd00162
    Location:324 → 366
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cd14392
    Location:882 → 922
    UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
    pfam02262
    Location:44 → 140
    Cbl_N; CBL proto-oncogene N-terminal domain 1
    pfam02761
    Location:123 → 205
    Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain

  10. NM_001321797.2 → NP_001308726.1  E3 ubiquitin-protein ligase CBL-B isoform h

    Status: REVIEWED

    Description
    Transcript Variant: Variants 11 and 12 encode the same isoform (h), which is the same length as isoform i but differs in the amino acid sequence.
    Source sequence(s)
    AC016138, AC112485, AC126185
    UniProtKB/TrEMBL
    B4DYP3
    Conserved Domains (5) summary
    cd09920
    Location:248 → 344
    SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
    cd14392
    Location:838 → 878
    UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
    cd16709
    Location:354 → 419
    RING-HC_Cbl-b; RING finger, HC subclass, found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
    pfam02262
    Location:44 → 164
    Cbl_N; CBL proto-oncogene N-terminal domain 1
    pfam02761
    Location:171 → 254
    Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain

  11. NM_001321798.2 → NP_001308727.1  E3 ubiquitin-protein ligase CBL-B isoform h

    Status: REVIEWED

    Description
    Transcript Variant: Variants 11 and 12 encode the same isoform (h), which is the same length as isoform i but differs in the amino acid sequence.
    Source sequence(s)
    AC016138, AC112485, AC126185
    UniProtKB/TrEMBL
    B4DYP3
    Conserved Domains (5) summary
    cd09920
    Location:248 → 344
    SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
    cd14392
    Location:838 → 878
    UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
    cd16709
    Location:354 → 419
    RING-HC_Cbl-b; RING finger, HC subclass, found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
    pfam02262
    Location:44 → 164
    Cbl_N; CBL proto-oncogene N-terminal domain 1
    pfam02761
    Location:171 → 254
    Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain

  12. NM_001321799.2 → NP_001308728.1  E3 ubiquitin-protein ligase CBL-B isoform i

    Status: REVIEWED

    Description
    Transcript Variant: Isoform i is the same length as isoform h but differs in the amino acid sequence.
    Source sequence(s)
    AC016138, AC112485
    UniProtKB/TrEMBL
    B4DYP3
    Conserved Domains (5) summary
    cd09920
    Location:199 → 295
    SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
    cd00162
    Location:324 → 366
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cd14392
    Location:838 → 878
    UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
    pfam02262
    Location:44 → 140
    Cbl_N; CBL proto-oncogene N-terminal domain 1
    pfam02761
    Location:123 → 205
    Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain

  13. NM_001321806.2 → NP_001308735.1  E3 ubiquitin-protein ligase CBL-B isoform j

    Status: REVIEWED

    Description
    Transcript Variant: Variants 14 and 15 encode the same isoform (j).
    Source sequence(s)
    AC016138, AC112485, AC126185
    Conserved Domains (3) summary
    cd09920
    Location:1 → 84
    SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
    cd00162
    Location:113 → 155
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cd14392
    Location:671 → 711
    UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins

  14. NM_001321807.2 → NP_001308736.1  E3 ubiquitin-protein ligase CBL-B isoform j

    Status: REVIEWED

    Description
    Transcript Variant: Variants 14 and 15 encode the same isoform (j).
    Source sequence(s)
    AC016138, AC112485, AC126185
    Conserved Domains (3) summary
    cd09920
    Location:1 → 84
    SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
    cd00162
    Location:113 → 155
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cd14392
    Location:671 → 711
    UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins

  15. NM_001321808.2 → NP_001308737.1  E3 ubiquitin-protein ligase CBL-B isoform k

    Status: REVIEWED

    Source sequence(s)
    AC016138, AC112485, AC126185
    Conserved Domains (3) summary
    cd09920
    Location:1 → 84
    SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
    cd00162
    Location:113 → 155
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cd14392
    Location:627 → 667
    UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins

  16. NM_001321811.2 → NP_001308740.1  E3 ubiquitin-protein ligase CBL-B isoform l

    Status: REVIEWED

    Description
    Transcript Variant: Variants 17 and 18 encode the same isoform (l).
    Source sequence(s)
    AC016138, AC112485, AC126185
    Conserved Domains (3) summary
    cd09920
    Location:1 → 84
    SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
    cd00162
    Location:113 → 155
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cd14392
    Location:622 → 662
    UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins

  17. NM_001321813.1 → NP_001308742.1  E3 ubiquitin-protein ligase CBL-B isoform l

    Status: REVIEWED

    Description
    Transcript Variant: Variants 17 and 18 encode the same isoform (l).
    Source sequence(s)
    AC016138, AC112485, AC126185
    Conserved Domains (3) summary
    cd09920
    Location:1 → 84
    SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
    cd00162
    Location:113 → 155
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cd14392
    Location:622 → 662
    UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins

  18. NM_001321816.2 → NP_001308745.1  E3 ubiquitin-protein ligase CBL-B isoform m

    Status: REVIEWED

    Source sequence(s)
    AC016138, AC112485, AC126185
    Conserved Domains (3) summary
    cd09920
    Location:1 → 84
    SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
    cd00162
    Location:113 → 155
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cd14392
    Location:578 → 618
    UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins

  19. NM_001321820.2 → NP_001308749.1  E3 ubiquitin-protein ligase CBL-B isoform n

    Status: REVIEWED

    Source sequence(s)
    AC016138, AC112485, AC126185
    Conserved Domains (1) summary
    cd14392
    Location:491 → 531
    UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins

  20. NM_001321822.2 → NP_001308751.1  E3 ubiquitin-protein ligase CBL-B isoform o

    Status: REVIEWED

    Source sequence(s)
    AC016138, AC112485, AC126185
    Conserved Domains (1) summary
    cd14392
    Location:488 → 528
    UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins

  21. NM_170662.5 → NP_733762.2  E3 ubiquitin-protein ligase CBL-B isoform b

    See identical proteins and their annotated locations for NP_733762.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and initiates translation from a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) is shorter at the N-terminus, compared to isoform a. Both variants 2 and 3 encode isoform b.
    Source sequence(s)
    AC016138, AI221219, AK094184, BC032851, BC065915, U26710
    Consensus CDS
    CCDS2948.1
    UniProtKB/Swiss-Prot
    A8K9S7, B7WNM4, Q13191, Q13192, Q13193, Q3LIC0, Q63Z43, Q8IVC5
    UniProtKB/TrEMBL
    B8K284
    Related
    ENSP00000377598.4, ENST00000394030.8
    Conserved Domains (5) summary
    cd09920
    Location:248 → 344
    SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
    cd14392
    Location:931 → 971
    UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
    cd16709
    Location:354 → 419
    RING-HC_Cbl-b; RING finger, HC subclass, found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
    pfam02262
    Location:44 → 165
    Cbl_N; CBL proto-oncogene N-terminal domain 1
    pfam02761
    Location:171 → 254
    Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain

RNA

  1. NR_135806.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC016138, AC112485, AC126185

  2. NR_135807.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC016138, AC112485, AC126185

  3. NR_135808.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC016138, AC112485, AC126185

  4. NR_135809.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC016138, AC112485, AC126185

  5. NR_135810.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC016138, AC112485, AC126185

  6. NR_135811.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC016138, AC112485, AC126185
    Related
    ENST00000645759.1

  7. NR_135812.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC016138, AC112485, AC126185

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    105655461..105869449 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011513257.2 → XP_011511559.1  E3 ubiquitin-protein ligase CBL-B isoform X2

    See identical proteins and their annotated locations for XP_011511559.1

    UniProtKB/Swiss-Prot
    A8K9S7, B7WNM4, Q13191, Q13192, Q13193, Q3LIC0, Q63Z43, Q8IVC5
    UniProtKB/TrEMBL
    B8K284
    Conserved Domains (5) summary
    cd09920
    Location:248 → 344
    SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
    cd14392
    Location:931 → 971
    UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
    cd16709
    Location:354 → 419
    RING-HC_Cbl-b; RING finger, HC subclass, found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
    pfam02262
    Location:44 → 165
    Cbl_N; CBL proto-oncogene N-terminal domain 1
    pfam02761
    Location:171 → 254
    Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain

  2. XM_017007398.2 → XP_016862887.1  E3 ubiquitin-protein ligase CBL-B isoform X5

    UniProtKB/TrEMBL
    B8K284

  3. XM_017007395.2 → XP_016862884.1  E3 ubiquitin-protein ligase CBL-B isoform X1

    UniProtKB/TrEMBL
    B8K284

  4. XM_047449112.1 → XP_047305068.1  E3 ubiquitin-protein ligase CBL-B isoform X2

    UniProtKB/Swiss-Prot
    A8K9S7, B7WNM4, Q13191, Q13192, Q13193, Q3LIC0, Q63Z43, Q8IVC5

  5. XM_017007400.2 → XP_016862889.1  E3 ubiquitin-protein ligase CBL-B isoform X6

    UniProtKB/TrEMBL
    B4DYP3

  6. XM_017007397.2 → XP_016862886.1  E3 ubiquitin-protein ligase CBL-B isoform X4

    UniProtKB/TrEMBL
    B8K284

  7. XM_017007396.2 → XP_016862885.1  E3 ubiquitin-protein ligase CBL-B isoform X3

    UniProtKB/TrEMBL
    B4DYP3

  8. XM_047449116.1 → XP_047305072.1  E3 ubiquitin-protein ligase CBL-B isoform X10

  9. XM_047449115.1 → XP_047305071.1  E3 ubiquitin-protein ligase CBL-B isoform X10

  10. XM_047449118.1 → XP_047305074.1  E3 ubiquitin-protein ligase CBL-B isoform X12

  11. XM_047449117.1 → XP_047305073.1  E3 ubiquitin-protein ligase CBL-B isoform X11

    Related
    ENSP00000384816.1, ENST00000403724.5

  12. XM_047449114.1 → XP_047305070.1  E3 ubiquitin-protein ligase CBL-B isoform X8

    Related
    ENSP00000496761.1, ENST00000646825.1

  13. XM_047449113.1 → XP_047305069.1  E3 ubiquitin-protein ligase CBL-B isoform X7

    Related
    ENSP00000494383.1, ENST00000645425.1

  14. XM_011513259.4 → XP_011511561.2  E3 ubiquitin-protein ligase CBL-B isoform X9

    UniProtKB/TrEMBL
    A0A2R8Y8D8

RNA

  1. XR_007095761.1 RNA Sequence

  2. XR_007095762.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    108373636..108587751 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054348226.1 → XP_054204201.1  E3 ubiquitin-protein ligase CBL-B isoform X2

    UniProtKB/Swiss-Prot
    A8K9S7, B7WNM4, Q13191, Q13192, Q13193, Q3LIC0, Q63Z43, Q8IVC5

  2. XM_054348230.1 → XP_054204205.1  E3 ubiquitin-protein ligase CBL-B isoform X5

  3. XM_054348225.1 → XP_054204200.1  E3 ubiquitin-protein ligase CBL-B isoform X1

  4. XM_054348227.1 → XP_054204202.1  E3 ubiquitin-protein ligase CBL-B isoform X2

    UniProtKB/Swiss-Prot
    A8K9S7, B7WNM4, Q13191, Q13192, Q13193, Q3LIC0, Q63Z43, Q8IVC5

  5. XM_054348231.1 → XP_054204206.1  E3 ubiquitin-protein ligase CBL-B isoform X6

  6. XM_054348229.1 → XP_054204204.1  E3 ubiquitin-protein ligase CBL-B isoform X4

  7. XM_054348228.1 → XP_054204203.1  E3 ubiquitin-protein ligase CBL-B isoform X3

  8. XM_054348236.1 → XP_054204211.1  E3 ubiquitin-protein ligase CBL-B isoform X10

  9. XM_054348235.1 → XP_054204210.1  E3 ubiquitin-protein ligase CBL-B isoform X10

  10. XM_054348238.1 → XP_054204213.1  E3 ubiquitin-protein ligase CBL-B isoform X12

  11. XM_054348237.1 → XP_054204212.1  E3 ubiquitin-protein ligase CBL-B isoform X11

  12. XM_054348233.1 → XP_054204208.1  E3 ubiquitin-protein ligase CBL-B isoform X8

  13. XM_054348232.1 → XP_054204207.1  E3 ubiquitin-protein ligase CBL-B isoform X7

  14. XM_054348234.1 → XP_054204209.1  E3 ubiquitin-protein ligase CBL-B isoform X9

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_004351.1: Suppressed sequence

    Description
    NM_004351.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q13191.2 GenPept UniProtKB/Swiss-Prot:Q13191

Gene LinkOut

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