U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

CanA-14F Calcineurin A at 14F [ Drosophila melanogaster (fruit fly) ]

Gene ID: 8674098, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
CanA-14Fprovided by FlyBase
Official Full Name
Calcineurin A at 14Fprovided by FlyBase
Primary source
FLYBASE:FBgn0267912
Locus tag
Dmel_CG9819
See related
AllianceGenome:FB:FBgn0267912
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CaN; canA-14F; CaNA-14F; CanA14F; CG9819; CnnA14D; CnnA14D(I); D27; DmCanA-14F; Dmel\CG9819; MRE12; PP2B; PpD27
Summary
Enables calmodulin-dependent protein phosphatase activity. Involved in sleep. Predicted to be part of calcineurin complex. Predicted to be active in cytoplasm. Is expressed in adult brain; adult optic lobe; and retina. Human ortholog(s) of this gene implicated in aortic valve stenosis; developmental and epileptic encephalopathy 91; and schizophrenia. Orthologous to several human genes including PPP3CB (protein phosphatase 3 catalytic subunit beta). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See CanA-14F in Genome Data Viewer
Location:
14E3-14F1; 1-54 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (16560684..16587172, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (16454717..16481205, complement)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Actin-related protein 2 Neighboring gene Protein phosphatase 2B at 14D Neighboring gene uncharacterized protein Neighboring gene Structural maintenance of chromosomes 3

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Reduced Cardiac Calcineurin Expression Mimics Long-Term Hypoxia-Induced Heart Defects in Drosophila. Zarndt R, et al. Circ Cardiovasc Genet, 2017 Oct. PMID 28986453, Free PMC Article
  2. Activation of Ca(2+) phosphatase Calcineurin regulates Parkin translocation to mitochondria and mitophagy in flies. Marchesan E, et al. Cell Death Differ, 2024 Feb. PMID 38238520, Free PMC Article
  3. The calcineurin regulator sra plays an essential role in female meiosis in Drosophila. Takeo S, et al. Curr Biol, 2006 Jul 25. PMID 16860743
  4. Calcineurin and its regulator sra/DSCR1 are essential for sleep in Drosophila. Nakai Y, et al. J Neurosci, 2011 Sep 7. PMID 21900555, Free PMC Article
  5. Pan-neuronal knockdown of calcineurin reduces sleep in the fruit fly, Drosophila melanogaster. Tomita J, et al. J Neurosci, 2011 Sep 14. PMID 21917797, Free PMC Article

See all (69) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. results indicate a role for Cn and calcium-dependent signal transduction in sleep and memory regulation.
    Title: Pan-neuronal knockdown of calcineurin reduces sleep in the fruit fly, Drosophila melanogaster.
Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables calmodulin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calmodulin-dependent protein phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calmodulin-dependent protein phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables calmodulin-dependent protein phosphatase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein serine/threonine phosphatase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in calcineurin-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in calcineurin-mediated signaling IEA
Inferred from Electronic Annotation
more info
  
involved_in sleep IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of calcineurin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
calcineurin A at 14F
Names
CG9819-PA
CG9819-PB
CG9819-PC
CG9819-PD
CanA-14F-PA
CanA-14F-PB
CanA-14F-PC
CanA-14F-PD
calcineurin
mRNA-like ncRNA in embryogenesis 12
protein phosphatase D27
protein phosphatase from PCR fragment D27
NP_001245717.1
NP_001259622.1
NP_727985.2
NP_727986.2

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    16560684..16587172 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001258788.2 → NP_001245717.1  calcineurin A at 14F, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001245717.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q27573, Q86NL0, Q9VXF1
    UniProtKB/TrEMBL
    M9NEL1
    Conserved Domains (2) summary
    smart00156
    Location:132 → 403
    PP2Ac; Protein phosphatase 2A homologues, catalytic domain
    cd07416
    Location:115 → 419
    MPP_PP2B; PP2B, metallophosphatase domain

  2. NM_167524.3 → NP_727986.2  calcineurin A at 14F, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_727986.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q27573, Q86NL0, Q9VXF1
    UniProtKB/TrEMBL
    M9NEL1
    Conserved Domains (2) summary
    smart00156
    Location:132 → 403
    PP2Ac; Protein phosphatase 2A homologues, catalytic domain
    cd07416
    Location:115 → 419
    MPP_PP2B; PP2B, metallophosphatase domain

  3. NM_001272693.2 → NP_001259622.1  calcineurin A at 14F, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259622.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q27573, Q86NL0, Q9VXF1
    UniProtKB/TrEMBL
    M9NEL1
    Conserved Domains (2) summary
    smart00156
    Location:132 → 403
    PP2Ac; Protein phosphatase 2A homologues, catalytic domain
    cd07416
    Location:115 → 419
    MPP_PP2B; PP2B, metallophosphatase domain

  4. NM_167523.3 → NP_727985.2  calcineurin A at 14F, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_727985.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q27573, Q86NL0, Q9VXF1
    UniProtKB/TrEMBL
    M9NEL1
    Conserved Domains (2) summary
    smart00156
    Location:132 → 403
    PP2Ac; Protein phosphatase 2A homologues, catalytic domain
    cd07416
    Location:115 → 419
    MPP_PP2B; PP2B, metallophosphatase domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9NEL1 M9NEL1
Q26249 Q26249
Q9VXF1.4 Q9VXF1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous