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VAMP8 vesicle associated membrane protein 8 [ Homo sapiens (human) ]

Gene ID: 8673, updated on 5-Mar-2024

Summary

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Official Symbol
VAMP8provided by HGNC
Official Full Name
vesicle associated membrane protein 8provided by HGNC
Primary source
HGNC:HGNC:12647
See related
Ensembl:ENSG00000118640 MIM:603177; AllianceGenome:HGNC:12647
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EDB; VAMP-8
Summary
This gene encodes an integral membrane protein that belongs to the synaptobrevin/vesicle-associated membrane protein subfamily of soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs). The encoded protein is involved in the fusion of synaptic vesicles with the presynaptic membrane.[provided by RefSeq, Jun 2010]
Expression
Ubiquitous expression in colon (RPKM 79.3), placenta (RPKM 77.9) and 24 other tissues See more
Orthologs
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Genomic context

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See VAMP8 in Genome Data Viewer
Location:
2p11.2
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (85577586..85582031)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (85579646..85584091)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (85804709..85809154)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene methionine adenosyltransferase 2A Neighboring gene gamma-glutamyl carboxylase Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16130 Neighboring gene NANOG hESC enhancer GRCh37_chr2:85793997-85794515 Neighboring gene RNA, 7SL, cytoplasmic 126, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16131 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16132 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16133 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:85806777-85807430 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:85807431-85808085 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:85808086-85808739 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:85811231-85812186 Neighboring gene vesicle associated membrane protein 5 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:85819815-85820316 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:85820317-85820816 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11704 Neighboring gene ring finger protein 181

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. VAMP8 suppresses the metastasis via DDX5/β-catenin signal pathway in osteosarcoma. Yang S, et al. Cancer Biol Ther, 2023 Dec 31. PMID 37405957, Free PMC Article
  2. Oxidative Stress Impairs Autophagy via Inhibition of Lysosomal Transport of VAMP8. Ohnishi Y, et al. Biol Pharm Bull, 2022. PMID 36328496
  3. Prefused lysosomes cluster on autophagosomes regulated by VAMP8. Chen Q, et al. Cell Death Dis, 2021 Oct 13. PMID 34645799, Free PMC Article
  4. No association of VAMP8 gene polymorphisms with glioma in a Chinese Han population. Zhou P, et al. Int J Clin Exp Pathol, 2015. PMID 26191281, Free PMC Article
  5. VAMP8-dependent fusion of recycling endosomes with the plasma membrane facilitates T lymphocyte cytotoxicity. Marshall MR, et al. J Cell Biol, 2015 Jul 6. PMID 26124288, Free PMC Article

See all (110) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The STX17-SNAP47-VAMP7/VAMP8 complex is the default SNARE complex mediating autophagosome-lysosome fusion.
    Title: The STX17-SNAP47-VAMP7/VAMP8 complex is the default SNARE complex mediating autophagosome-lysosome fusion.
  2. VAMP8 suppresses the metastasis via DDX5/beta-catenin signal pathway in osteosarcoma.
    Title: VAMP8 suppresses the metastasis via DDX5/β-catenin signal pathway in osteosarcoma.
  3. Oxidative Stress Impairs Autophagy via Inhibition of Lysosomal Transport of VAMP8.
    Title: Oxidative Stress Impairs Autophagy via Inhibition of Lysosomal Transport of VAMP8.
  4. Prefused lysosomes cluster on autophagosomes regulated by VAMP8.
    Title: Prefused lysosomes cluster on autophagosomes regulated by VAMP8.
  5. Stimulating TRPM7 suppresses cancer cell proliferation and metastasis by inhibiting autophagy.
    Title: Stimulating TRPM7 suppresses cancer cell proliferation and metastasis by inhibiting autophagy.
  6. mTOR-mediated phosphorylation of VAMP8 and SCFD1 regulates autophagosome maturation.
    Title: mTOR-mediated phosphorylation of VAMP8 and SCFD1 regulates autophagosome maturation.
  7. Organelle tethering, pore formation and SNARE compensation in the late endocytic pathway.
    Title: Organelle tethering, pore formation and SNARE compensation in the late endocytic pathway.
  8. Association of KLK3, VAMP8 and MDM4 Genetic Variants within microRNA Binding Sites with Prostate Cancer: Evidence from Serbian Population.
    Title: Association of KLK3, VAMP8 and MDM4 Genetic Variants within microRNA Binding Sites with Prostate Cancer: Evidence from Serbian Population.
  9. Decoding three distinct states of the Syntaxin17 SNARE motif in mediating autophagosome-lysosome fusion.
    Title: Decoding three distinct states of the Syntaxin17 SNARE motif in mediating autophagosome-lysosome fusion.
  10. data show that defects in adaptor protein complex 3-dependent maturation of Weibel-Palade bodies impairs exocytosis by affecting the recruitment of VAMP8.
    Title: Defective AP-3-dependent VAMP8 trafficking impairs Weibel-Palade body exocytosis in Hermansky-Pudlak Syndrome type 2 blood outgrowth endothelial cells.
Submit: New GeneRIF Correction See all GeneRIFs (36)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Seven prostate cancer susceptibility loci identified by a multi-stage genome-wide association study.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables SNAP receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables chloride channel inhibitor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables syntaxin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in SNARE complex assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in autophagosome maturation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in autophagosome membrane docking IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in defense response to virus IEA
Inferred from Electronic Annotation
more info
  
NOT involved_in eosinophil degranulation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mucus secretion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mucus secretion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of secretion by cell IDA
Inferred from Direct Assay
more info
 PubMed 
NOT involved_in neutrophil degranulation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of histamine secretion by mast cell IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of protein localization to plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within symbiont entry into host cell IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in vesicle fusion IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of SNARE complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of SNARE complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in azurophil granule membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in azurophil granule membrane TAS
Traceable Author Statement
more info
  
located_in clathrin-coated endocytic vesicle membrane TAS
Traceable Author Statement
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in early endosome TAS
Traceable Author Statement
more info
 PubMed 
located_in early endosome membrane IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular exosome HDA PubMed 
located_in late endosome membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in lysosomal membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in mucin granule IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mucin granule IDA
Inferred from Direct Assay
more info
 PubMed 
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in phagocytic vesicle membrane TAS
Traceable Author Statement
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
  
located_in recycling endosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in recycling endosome membrane TAS
Traceable Author Statement
more info
  
located_in secretory granule membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in secretory granule membrane TAS
Traceable Author Statement
more info
  
located_in specific granule membrane TAS
Traceable Author Statement
more info
  
located_in tertiary granule membrane TAS
Traceable Author Statement
more info
  
located_in vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in zymogen granule membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
vesicle-associated membrane protein 8
Names
vesicle-associated membrane protein 8 (endobrevin)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_022887.1 RefSeqGene

    Range
    5096..9541
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_003761.5 → NP_003752.2  vesicle-associated membrane protein 8

    See identical proteins and their annotated locations for NP_003752.2

    Status: REVIEWED

    Source sequence(s)
    BC001634, BM702226, BX092149
    Consensus CDS
    CCDS1979.1
    UniProtKB/Swiss-Prot
    O60625, Q53SP9, Q6IB09, Q9BV40
    Related
    ENSP00000263864.5, ENST00000263864.10
    Conserved Domains (1) summary
    cd15868
    Location:10 → 77
    R-SNARE_VAMP8; SNARE motif of VAMP8

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    85577586..85582031
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017005170.2 → XP_016860659.1  vesicle-associated membrane protein 8 isoform X1

    UniProtKB/TrEMBL
    B8ZZT4
    Related
    ENSP00000387094.1, ENST00000409760.1
    Conserved Domains (1) summary
    cl22856
    Location:10 → 55
    SNARE; SNARE motif

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    85579646..85584091
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054344328.1 → XP_054200303.1  vesicle-associated membrane protein 8 isoform X1

    UniProtKB/TrEMBL
    B8ZZT4
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9BV40.1 GenPept UniProtKB/Swiss-Prot:Q9BV40

Gene LinkOut

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