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EIF3B eukaryotic translation initiation factor 3 subunit B [ Homo sapiens (human) ]

Gene ID: 8662, updated on 3-Apr-2024

Summary

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Official Symbol
EIF3Bprovided by HGNC
Official Full Name
eukaryotic translation initiation factor 3 subunit Bprovided by HGNC
Primary source
HGNC:HGNC:3280
See related
Ensembl:ENSG00000106263 MIM:603917; AllianceGenome:HGNC:3280
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PRT1; EIF3S9; EIF3-ETA; EIF3-P110; EIF3-P116
Summary
Enables RNA binding activity. Contributes to translation initiation factor activity. Involved in several processes, including IRES-dependent viral translational initiation; translational initiation; and viral translational termination-reinitiation. Located in extracellular exosome. Part of eukaryotic translation initiation factor 3 complex. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis (RPKM 39.5), bone marrow (RPKM 32.1) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
7p22.3
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (2354086..2380745)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (2467574..2494152)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (2393721..2420380)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:2297547-2298326 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:2298327-2299106 Neighboring gene microRNA 6836 Neighboring gene sorting nexin 8 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:2309692-2310302 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:2310912-2311521 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:2311522-2312130 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25518 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25519 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25520 Neighboring gene inner mitochondrial membrane peptidase subunit 1 pseudogene 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25521 Neighboring gene OCT4-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:2340879-2341379 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:2341882-2342382 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25522 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:2349114-2349623 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:2349624-2350134 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:2350135-2350643 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25524 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25523 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25525 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25526 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17865 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:2354180-2354680 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:2354681-2355181 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:2393253-2393808 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17867 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17868 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17869 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:2416395-2416894 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:2418983-2419483 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:2429085-2429981 Neighboring gene kinesin family member 19B, pseudogene Neighboring gene NGRN pseudogene 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Eukaryotic translation initiation factor 3 subunit B could serve as a potential prognostic predictor for breast cancer. Song S, et al. Bioengineered, 2022 Feb. PMID 35040374, Free PMC Article
  2. EIF3B Associates with Exacerbated Clinical Features, Poor Treatment Response and Survival in Adult Philadelphia Chromosome Negative Acute Lymphoblastic Leukemia Patients. Zhu F, et al. Technol Cancer Res Treat, 2021 Jan-Dec. PMID 34617851, Free PMC Article
  3. Eukaryotic translation initiation factor 3 subunit b is a novel oncogenic factor in prostate cancer. Xiang P, et al. Mamm Genome, 2020 Aug. PMID 32556998
  4. Downregulation of eukaryotic translation initiation factor 3b inhibited proliferation and metastasis of gastric cancer. Ma F, et al. Cell Death Dis, 2019 Aug 19. PMID 31423012, Free PMC Article
  5. Eukaryotic translation initiation factor 3B is overexpressed and correlates with deteriorated tumor features and unfavorable survival profiles in cervical cancer patients. Zhu P, et al. Cancer Biomark, 2019. PMID 31322539

See all (218) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. EIF3B stabilizes PTGS2 expression by counteracting MDM2-mediated ubiquitination to promote the development and progression of malignant melanoma.
    Title: EIF3B stabilizes PTGS2 expression by counteracting MDM2-mediated ubiquitination to promote the development and progression of malignant melanoma.
  2. Eukaryotic translation initiation factor 3 subunit B could serve as a potential prognostic predictor for breast cancer.
    Title: Eukaryotic translation initiation factor 3 subunit B could serve as a potential prognostic predictor for breast cancer.
  3. EIF3B Associates with Exacerbated Clinical Features, Poor Treatment Response and Survival in Adult Philadelphia Chromosome Negative Acute Lymphoblastic Leukemia Patients.
    Title: EIF3B Associates with Exacerbated Clinical Features, Poor Treatment Response and Survival in Adult Philadelphia Chromosome Negative Acute Lymphoblastic Leukemia Patients.
  4. Eukaryotic translation initiation factor 3 subunit b is a novel oncogenic factor in prostate cancer.
    Title: Eukaryotic translation initiation factor 3 subunit b is a novel oncogenic factor in prostate cancer.
  5. Downregulation of eukaryotic translation initiation factor 3b inhibited proliferation and metastasis of gastric cancer.
    Title: Downregulation of eukaryotic translation initiation factor 3b inhibited proliferation and metastasis of gastric cancer.
  6. High EIF3B expression is associated with cervical cancer.
    Title: Eukaryotic translation initiation factor 3B is overexpressed and correlates with deteriorated tumor features and unfavorable survival profiles in cervical cancer patients.
  7. Inhibition of EIF3B gene expression significantly inhibit the proliferation of ovarian cancer cells and increase the apoptosis of ovarian cancer cells.
    Title: Effects of EIF3B gene downregulation on apoptosis and proliferation of human ovarian cancer SKOV3 and HO-8910 cells.
  8. EIF3B overexpression correlates with advanced disease conditions and poor prognosis, and it promotes cells proliferation while inhibits cells apoptosis in NSCLC.
    Title: EIF3B correlates with advanced disease stages and poor prognosis, and it promotes proliferation and inhibits apoptosis in non-small cell lung cancer.
  9. Study demonstrated that EIF3B expression was up-regulated in esophageal squamous cell carcinoma cells and negatively correlated with the prognosis of patients.
    Title: Eukaryotic translation initiation factor 3B accelerates the progression of esophageal squamous cell carcinoma by activating β-catenin signaling pathway.
  10. The human eIF3b and octameric eIF3a subunits serve as the nucleation core around which other subunits assemble in an ordered way into two interconnected modules: the yeast-like core and the octamer.
    Title: Human eIF3b and eIF3a serve as the nucleation core for the assembly of eIF3 into two interconnected modules: the yeast-like core and the octamer.
Submit: New GeneRIF Correction See all GeneRIFs (18)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Pol gag-pol HIV-1 Pol is identified to have a physical interaction with eukaryotic translation initiation factor 3, subunit B (EIF3B) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
Pr55(Gag) gag HIV-1 Gag co-localizes with eIF3b in the cellullar cytoplasmic compartment PubMed
retropepsin gag-pol HIV-1 PR is identified to have a physical interaction with eukaryotic translation initiation factor 3, subunit B (EIF3B) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC104664, MGC131875

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables molecular adaptor activity TAS
Traceable Author Statement
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
contributes_to translation initiation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to translation initiation factor activity IC
Inferred by Curator
more info
 PubMed 
contributes_to translation initiation factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables translation initiation factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables translation initiation factor binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in IRES-dependent viral translational initiation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in formation of cytoplasmic translation initiation complex NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of translational initiation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in translational initiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in translational initiation IC
Inferred by Curator
more info
 PubMed 
involved_in translational initiation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in viral translational termination-reinitiation IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasmic stress granule IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
  
part_of eukaryotic 43S preinitiation complex IEA
Inferred from Electronic Annotation
more info
  
part_of eukaryotic 48S preinitiation complex IEA
Inferred from Electronic Annotation
more info
  
part_of eukaryotic translation initiation factor 3 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of eukaryotic translation initiation factor 3 complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of eukaryotic translation initiation factor 3 complex IPI
Inferred from Physical Interaction
more info
 PubMed 
part_of eukaryotic translation initiation factor 3 complex, eIF3m IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular exosome HDA PubMed 
located_in synapse IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
eukaryotic translation initiation factor 3 subunit B
Names
eukaryotic translation initiation factor 3 subunit 9
eukaryotic translation initiation factor 3, subunit 9 (eta, 116kD)
eukaryotic translation initiation factor 3, subunit 9 eta, 116kDa
protein synthesis 1
prt1 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001037283.2 → NP_001032360.1  eukaryotic translation initiation factor 3 subunit B isoform 1

    See identical proteins and their annotated locations for NP_001032360.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) represents the longest transcript. Variants 1, 2 and 3 encode the same isoform (1).
    Source sequence(s)
    AC004971, BQ045103, U78525
    Consensus CDS
    CCDS5332.1
    UniProtKB/Swiss-Prot
    A4D208, P55884, Q2NL77, Q9UMF9
    UniProtKB/TrEMBL
    B4DV79
    Related
    ENSP00000354125.4, ENST00000360876.9
    Conserved Domains (4) summary
    COG5354
    Location:305 → 805
    COG5354; Uncharacterized protein, contains Trp-Asp (WD) repeat [General function prediction only]
    PRK07764
    Location:4 → 161
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    sd00039
    Location:376 → 423
    7WD40; WD40 repeat [structural motif]
    cd12278
    Location:184 → 264
    RRM_eIF3B; RNA recognition motif (RRM) found in eukaryotic translation initiation factor 3 subunit B (eIF-3B) and similar proteins

  2. NM_001362791.2 → NP_001349720.1  eukaryotic translation initiation factor 3 subunit B isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 3' UTR compared to variant 2. Variants 1, 2 and 3 encode the same isoform (1).
    Source sequence(s)
    AC004971, BC009986, U78525
    Consensus CDS
    CCDS5332.1
    UniProtKB/Swiss-Prot
    A4D208, P55884, Q2NL77, Q9UMF9
    UniProtKB/TrEMBL
    B4DV79
    Conserved Domains (4) summary
    COG5354
    Location:305 → 805
    COG5354; Uncharacterized protein, contains Trp-Asp (WD) repeat [General function prediction only]
    PRK07764
    Location:4 → 161
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    sd00039
    Location:376 → 423
    7WD40; WD40 repeat [structural motif]
    cd12278
    Location:184 → 264
    RRM_eIF3B; RNA recognition motif (RRM) found in eukaryotic translation initiation factor 3 subunit B (eIF-3B) and similar proteins

  3. NM_001362792.2 → NP_001349721.1  eukaryotic translation initiation factor 3 subunit B isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC004840, AC004971, BQ045103, DA781713
    UniProtKB/TrEMBL
    Q96G38
    Conserved Domains (2) summary
    COG5354
    Location:33 → 533
    COG5354; Uncharacterized protein, contains Trp-Asp (WD) repeat [General function prediction only]
    sd00039
    Location:104 → 151
    7WD40; WD40 repeat [structural motif]

  4. NM_001362793.2 → NP_001349722.1  eukaryotic translation initiation factor 3 subunit B isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC004840, AC004971, BQ045103, DA781713
    UniProtKB/TrEMBL
    Q96G38
    Conserved Domains (2) summary
    COG5354
    Location:33 → 533
    COG5354; Uncharacterized protein, contains Trp-Asp (WD) repeat [General function prediction only]
    sd00039
    Location:104 → 151
    7WD40; WD40 repeat [structural motif]

  5. NM_003751.4 → NP_003742.2  eukaryotic translation initiation factor 3 subunit B isoform 1

    See identical proteins and their annotated locations for NP_003742.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) differs in the 3' UTR compared to variant 2. Variants 1, 2 and 3 encode the same isoform (1).
    Source sequence(s)
    AC004971, BQ015102, U78525
    Consensus CDS
    CCDS5332.1
    UniProtKB/Swiss-Prot
    A4D208, P55884, Q2NL77, Q9UMF9
    UniProtKB/TrEMBL
    B4DV79
    Related
    ENSP00000380206.2, ENST00000397011.2
    Conserved Domains (4) summary
    COG5354
    Location:305 → 805
    COG5354; Uncharacterized protein, contains Trp-Asp (WD) repeat [General function prediction only]
    PRK07764
    Location:4 → 161
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    sd00039
    Location:376 → 423
    7WD40; WD40 repeat [structural motif]
    cd12278
    Location:184 → 264
    RRM_eIF3B; RNA recognition motif (RRM) found in eukaryotic translation initiation factor 3 subunit B (eIF-3B) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    2354086..2380745
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011515599.2 → XP_011513901.1  eukaryotic translation initiation factor 3 subunit B isoform X1

    See identical proteins and their annotated locations for XP_011513901.1

    UniProtKB/Swiss-Prot
    A4D208, P55884, Q2NL77, Q9UMF9
    UniProtKB/TrEMBL
    B4DV79
    Conserved Domains (4) summary
    COG5354
    Location:305 → 805
    COG5354; Uncharacterized protein, contains Trp-Asp (WD) repeat [General function prediction only]
    PRK07764
    Location:4 → 161
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    sd00039
    Location:376 → 423
    7WD40; WD40 repeat [structural motif]
    cd12278
    Location:184 → 264
    RRM_eIF3B; RNA recognition motif (RRM) found in eukaryotic translation initiation factor 3 subunit B (eIF-3B) and similar proteins

  2. XM_047421000.1 → XP_047276956.1  eukaryotic translation initiation factor 3 subunit B isoform X2

    UniProtKB/TrEMBL
    A4D210

  3. XM_047421001.1 → XP_047276957.1  eukaryotic translation initiation factor 3 subunit B isoform X3

  4. XM_017012753.2 → XP_016868242.1  eukaryotic translation initiation factor 3 subunit B isoform X4

    UniProtKB/TrEMBL
    Q86UM1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    2467574..2494152
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054359283.1 → XP_054215258.1  eukaryotic translation initiation factor 3 subunit B isoform X3

  2. XM_054359282.1 → XP_054215257.1  eukaryotic translation initiation factor 3 subunit B isoform X2

  3. XM_054359281.1 → XP_054215256.1  eukaryotic translation initiation factor 3 subunit B isoform X1

  4. XM_054359284.1 → XP_054215259.1  eukaryotic translation initiation factor 3 subunit B isoform X4

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_182712.1: Suppressed sequence

    Description
    NM_182712.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P55884.3 GenPept UniProtKB/Swiss-Prot:P55884

Gene LinkOut

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