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RNASET2 ribonuclease T2 [ Homo sapiens (human) ]

Gene ID: 8635, updated on 5-Mar-2024

Summary

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Official Symbol
RNASET2provided by HGNC
Official Full Name
ribonuclease T2provided by HGNC
Primary source
HGNC:HGNC:21686
See related
Ensembl:ENSG00000026297 MIM:612944; AllianceGenome:HGNC:21686
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RNASE6PL; bA514O12.3
Summary
This ribonuclease gene is a novel member of the Rh/T2/S-glycoprotein class of extracellular ribonucleases. It is a single copy gene that maps to 6q27, a region associated with human malignancies and chromosomal rearrangement. [provided by RefSeq, Jul 2008]
Expression
Broad expression in spleen (RPKM 93.0), colon (RPKM 39.0) and 24 other tissues See more
Orthologs
mouse all
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Genomic context

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Location:
6q27
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (166922113..166956550, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (168304858..168339306, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (167335601..167370038, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124901461 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:167315271-167315770 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:167316941-167317622 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:167317623-167318303 Neighboring gene RPS6KA2 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25440 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:167354383-167354883 Neighboring gene protein GVQW1-like Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:167363029-167363714 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25441 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:167364403-167365088 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17784 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17785 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17786 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25443 Neighboring gene CRISPRi-validated cis-regulatory element chr6.5886 Neighboring gene uncharacterized LOC105378120 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25444 Neighboring gene microRNA 3939

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Diagnostic and therapeutic potential of RNASET2 in Crohn's disease: Disease-risk polymorphism modulates allelic-imbalance in expression and circulating protein levels and recombinant-RNASET2 attenuates pro-inflammatory cytokine secretion. Biener-Ramanujan E, et al. Front Immunol, 2022. PMID 36466822, Free PMC Article
  2. A potential role of human RNASET2 overexpression in the pathogenesis of Graves' disease. Gallo D, et al. Endocrine, 2023 Jan. PMID 36180758
  3. Human RNASET2: A Highly Pleiotropic and Evolutionary Conserved Tumor Suppressor Gene Involved in the Control of Ovarian Cancer Pathogenesis. Bruno A, et al. Int J Mol Sci, 2022 Aug 13. PMID 36012339, Free PMC Article
  4. Hypoxia Enhances the Expression of RNASET2 in Human Monocyte-Derived Dendritic Cells: Role of PI3K/AKT Pathway. Monaci S, et al. Int J Mol Sci, 2021 Jul 15. PMID 34299186, Free PMC Article
  5. Zebrafish disease model of human RNASET2-deficient cystic leukoencephalopathy displays abnormalities in early microglia. Weber T, et al. Biol Open, 2020 May 7. PMID 32295832, Free PMC Article

See all (69) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Systematic analysis of RNASET2 gene as a potential prognostic and immunological biomarker in clear cell renal cell carcinoma.
    Title: Systematic analysis of RNASET2 gene as a potential prognostic and immunological biomarker in clear cell renal cell carcinoma.
  2. HIF2alpha-induced upregulation of RNASET2 promotes triglyceride synthesis and enhances cell migration in clear cell renal cell carcinoma.
    Title: HIF2α-induced upregulation of RNASET2 promotes triglyceride synthesis and enhances cell migration in clear cell renal cell carcinoma.
  3. A potential role of human RNASET2 overexpression in the pathogenesis of Graves' disease.
    Title: A potential role of human RNASET2 overexpression in the pathogenesis of Graves' disease.
  4. Diagnostic and therapeutic potential of RNASET2 in Crohn's disease: Disease-risk polymorphism modulates allelic-imbalance in expression and circulating protein levels and recombinant-RNASET2 attenuates pro-inflammatory cytokine secretion.
    Title: Diagnostic and therapeutic potential of RNASET2 in Crohn's disease: Disease-risk polymorphism modulates allelic-imbalance in expression and circulating protein levels and recombinant-RNASET2 attenuates pro-inflammatory cytokine secretion.
  5. Myelin oligodendrocyte glycoprotein-associated disease is associated with BANK1, RNASET2 and TNIP1 polymorphisms.
    Title: Myelin oligodendrocyte glycoprotein-associated disease is associated with BANK1, RNASET2 and TNIP1 polymorphisms.
  6. Human RNASET2: A Highly Pleiotropic and Evolutionary Conserved Tumor Suppressor Gene Involved in the Control of Ovarian Cancer Pathogenesis.
    Title: Human RNASET2: A Highly Pleiotropic and Evolutionary Conserved Tumor Suppressor Gene Involved in the Control of Ovarian Cancer Pathogenesis.
  7. FBXO6-mediated RNASET2 ubiquitination and degradation governs the development of ovarian cancer.
    Title: FBXO6-mediated RNASET2 ubiquitination and degradation governs the development of ovarian cancer.
  8. Zebrafish disease model of human RNASET2-deficient cystic leukoencephalopathy displays abnormalities in early microglia.
    Title: Zebrafish disease model of human RNASET2-deficient cystic leukoencephalopathy displays abnormalities in early microglia.
  9. Hypoxia Enhances the Expression of RNASET2 in Human Monocyte-Derived Dendritic Cells: Role of PI3K/AKT Pathway.
    Title: Hypoxia Enhances the Expression of RNASET2 in Human Monocyte-Derived Dendritic Cells: Role of PI3K/AKT Pathway.
  10. Immune Sensing of Synthetic, Bacterial, and Protozoan RNA by Toll-like Receptor 8 Requires Coordinated Processing by RNase T2 and RNase 2.
    Title: Immune Sensing of Synthetic, Bacterial, and Protozoan RNA by Toll-like Receptor 8 Requires Coordinated Processing by RNase T2 and RNase 2.
Submit: New GeneRIF Correction See all GeneRIFs (43)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Cystic leukoencephalopathy without megalencephaly
MedGen: C2751843 OMIM: 612951 GeneReviews: Not available
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EBI GWAS Catalog

Description
A genome-wide association study identifies two new risk loci for Graves' disease.
EBI GWAS Catalog
Genome-wide association study for vitiligo identifies susceptibility loci at 6q27 and the MHC.
EBI GWAS Catalog
Genome-wide association study of Crohn's disease in Koreans revealed three new susceptibility loci and common attributes of genetic susceptibility across ethnic populations.
EBI GWAS Catalog
Genome-wide association study of endometrial cancer in E2C2.
EBI GWAS Catalog
Genome-wide association study of primary dentition pit-and-fissure and smooth surface caries.
EBI GWAS Catalog
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ42372

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA endonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA nuclease activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ribonuclease T2 activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in RNA catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in RNA catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in azurophil granule lumen TAS
Traceable Author Statement
more info
  
located_in endoplasmic reticulum lumen IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular exosome HDA PubMed 
is_active_in extracellular region IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular region TAS
Traceable Author Statement
more info
  
located_in extracellular space HDA PubMed 
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 
located_in lysosomal lumen IEA
Inferred from Electronic Annotation
more info
  
located_in lysosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrial intermembrane space IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ribonuclease T2
Names
ribonuclease 6
NP_003721.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016280.2 RefSeqGene

    Range
    5040..39477
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_003730.6 → NP_003721.2  ribonuclease T2 precursor

    See identical proteins and their annotated locations for NP_003721.2

    Status: REVIEWED

    Source sequence(s)
    AL133458, AL159163
    Consensus CDS
    CCDS5295.1
    UniProtKB/Swiss-Prot
    B2RDA7, E1P5C3, O00584, Q5T8Q0, Q8TCU2, Q9BZ46, Q9BZ47
    UniProtKB/TrEMBL
    D6RHI9
    Related
    ENSP00000426455.2, ENST00000508775.6
    Conserved Domains (1) summary
    cd01061
    Location:34 → 227
    RNase_T2_euk; Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    166922113..166956550 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    168304858..168339306 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_017795.1: Suppressed sequence

    Description
    NM_017795.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.

  2. NM_018726.1: Suppressed sequence

    Description
    NM_018726.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O00584.2 GenPept UniProtKB/Swiss-Prot:O00584

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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