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cadA calcium-dependent cell adhesion molecule-1 [ Dictyostelium discoideum AX4 ]

Gene ID: 8625286, updated on 18-Sep-2024

Summary

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Official Symbol
cadA
Official Full Name
calcium-dependent cell adhesion molecule-1
Primary source
dictyBase:DDB_G0285793
Locus tag
DDB_G0285793
See related
AmoebaDB:DDB_G0285793; VEuPathDB:DDB_G0285793
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Dictyostelium discoideum AX4 (strain: AX4)
Lineage
Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales; Dictyosteliaceae; Dictyostelium
Old locus tag
DDBDRAFT_0186681; DDBDRAFT_0191175; DDB_0186681; DDB_0191175
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Genomic context

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Location:
chromosome: 4
Exon count:
3
Sequence:
Chromosome: 4; NC_007090.3 (3656149..3656978)

Chromosome 4 - NC_007090.3Genomic Context describing neighboring genes Neighboring gene hypothetical protein Neighboring gene deoxyhypusine synthase Neighboring gene tRNA-Tyr Neighboring gene hypothetical protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_007090.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Social amoebae establish a protective interface with their bacterial associates by lectin agglutination. Farinholt T, et al. Sci Adv, 2019 Jul. PMID 31355329, Free PMC Article
  2. Characterization of the cell adhesion molecule gp24 in Dictyostelium discoideum. Mediation of cell-cell adhesion via a Ca(2+)-dependent mechanism. Brar SK, et al. J Biol Chem, 1993 Nov 25. PMID 8227052
  3. Molecular cloning and characterization of DdCAD-1, a Ca2+-dependent cell-cell adhesion molecule, in Dictyostelium discoideum. Wong EF, et al. J Biol Chem, 1996 Jul 5. PMID 8663243
  4. The cell adhesion molecule DdCAD-1 regulates morphogenesis through differential spatiotemporal expression in Dictyostelium discoideum. Sriskanthadevan S, et al. Development, 2011 Jun. PMID 21561987
  5. Cell adhesion molecule DdCAD-1 is imported into contractile vacuoles by membrane invagination in a Ca2+- and conformation-dependent manner. Sriskanthadevan S, et al. J Biol Chem, 2009 Dec 25. PMID 19875452, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. DdCAD-1 phosphorylation via the RasG signalling pathway affects Dictyostelium cell adhesion.
    Title: An activated Ras protein alters cell adhesion by dephosphorylating Dictyostelium DdCAD-1.
  2. CAD-1 has a major role in homophilic binding, and in tethering a protein to the cell membrane.
    Title: Solution structures of the adhesion molecule DdCAD-1 reveal new insights into Ca(2+)-dependent cell-cell adhesion.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by dictyBase

Function Evidence Code Pubs
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables calmodulin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calmodulin binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within aggregation involved in sorocarp development TAS
Traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within biological process involved in interaction with symbiont IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell adhesion IEA
Inferred from Electronic Annotation
more info
  
involved_in cell-cell adhesion IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within defense response to Gram-negative bacterium IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of gene expression IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to curcumin IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within sorocarp development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within sorocarp morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cell cortex TAS
Traceable Author Statement
more info
 PubMed 
is_active_in cell-cell junction IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cell-cell junction IDA
Inferred from Direct Assay
more info
 PubMed 
located_in contractile vacuole IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endocytic vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in external side of plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular matrix IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in extracellular region IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in filopodium IDA
Inferred from Direct Assay
more info
 PubMed 
located_in lamellipodium IDA
Inferred from Direct Assay
more info
 PubMed 
located_in lipid droplet HDA PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in phagocytic vesicle HDA PubMed 
is_active_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in ruffle IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
calcium-dependent cell adhesion molecule-1
Names
glycoprotein gp24

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_007090.3 Reference assembly

    Range
    3656149..3656978
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_632956.1 → XP_638048.1  calcium-dependent cell adhesion molecule-1 [Dictyostelium discoideum AX4]

    See identical proteins and their annotated locations for XP_638048.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P54657, Q23855, Q54MQ4
    Conserved Domains (2) summary
    pfam08964
    Location:4 → 93
    Crystall_3; Beta/Gamma crystallin
    pfam14564
    Location:100 → 209
    Membrane_bind; Membrane binding
Nucleotide Protein
Heading Accession and Version

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