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carA-1 G-protein-coupled receptor [ Dictyostelium discoideum AX4 ]

Gene ID: 8618967, updated on 18-Sep-2024

Summary

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Official Symbol
carA-1
Official Full Name
G-protein-coupled receptor
Primary source
dictyBase:DDB_G0273397
Locus tag
DDB_G0273397
See related
AmoebaDB:DDB_G0273397; VEuPathDB:DDB_G0273397
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Dictyostelium discoideum AX4 (strain: AX4)
Lineage
Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales; Dictyosteliaceae; Dictyostelium
Old locus tag
DDBDRAFT_0168197; DDBDRAFT_0185024; DDB_0168197; DDB_0185024
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Genomic context

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Location:
chromosome: 2
Exon count:
2
Sequence:
Chromosome: 2; NC_007088.5 (2964374..2965695, complement)

Chromosome 2 - NC_007088.5Genomic Context describing neighboring genes Neighboring gene hypothetical protein Neighboring gene MEK1 interacting protein 1 Neighboring gene ARK family protein kinase Neighboring gene hypothetical protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_007088.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Constitutively active G protein-coupled receptor mutants block dictyostelium development. Zhang M, et al. Mol Biol Cell, 2005 Feb. PMID 15574880, Free PMC Article
  2. Overexpression of the cAMP receptor 1 in growing Dictyostelium cells. Johnson RL, et al. Biochemistry, 1991 Jul 16. PMID 1648967
  3. Gene targeting of the aggregation stage cAMP receptor cAR1 in Dictyostelium. Sun TJ, et al. Genes Dev, 1991 Apr. PMID 1849108
  4. Localization of cyclic-AMP receptors with acidosomes in Dictyostelium discoideum. Padh H, et al. FEBS Lett, 1995 Jul 17. PMID 7628637
  5. Random mutagenesis of the cAMP chemoattractant receptor, cAR1, of Dictyostelium. Mutant classes that cause discrete shifts in agonist affinity and lock the receptor in a novel activational intermediate. Kim JY, et al. J Biol Chem, 1997 Jan 24. PMID 8999903

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by dictyBase

Function Evidence Code Pubs
enables G protein-coupled chemoattractant receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables GTPase regulator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables adenylate cyclase activator activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables cAMP binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables cAMP binding IEA
Inferred from Electronic Annotation
more info
  
enables cAMP binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables cAMP receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables cAMP receptor activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables pathogen-derived receptor ligand activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase activator activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in ERK1 and ERK2 cascade IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in G protein-coupled purinergic nucleotide receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in adaptation of signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in adenylate cyclase-activating G protein-coupled cAMP receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in adenylate cyclase-activating G protein-coupled cAMP receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in adenylate cyclase-activating G protein-coupled cAMP receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in aggregation involved in sorocarp development IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in aggregation involved in sorocarp development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cGMP-mediated signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell surface receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in cell surface receptor signaling pathway via STAT IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in chemotaxis IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in chemotaxis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in desensitization of G protein-coupled receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in oscillatory cAMP signaling IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within regulation of phagocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to UV-C IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to catechin IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to curcumin IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to differentiation-inducing factor 1 HDA PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cell leading edge IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cell surface IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in early endosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane TAS
Traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
G-protein-coupled receptor
Names
cAMP receptor 1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_007088.5 Reference assembly

    Range
    2964374..2965695 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_639511.1 → XP_644603.1  G-protein-coupled receptor [Dictyostelium discoideum AX4]

    See identical proteins and their annotated locations for XP_644603.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P13773, Q557I7
    Conserved Domains (2) summary
    pfam05462
    Location:4 → 308
    Dicty_CAR; Slime mold cyclic AMP receptor
    cl21561
    Location:24 → 178
    7tm_4; Olfactory receptor
Nucleotide Protein
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