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corA WD-40 repeat-containing protein [ Dictyostelium discoideum AX4 ]

Gene ID: 8616153, updated on 18-Sep-2024

Summary

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Official Symbol
corA
Official Full Name
WD-40 repeat-containing protein
Primary source
dictyBase:DDB_G0267382
Locus tag
DDB_G0267382
See related
AmoebaDB:DDB_G0267382; VEuPathDB:DDB_G0267382
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Dictyostelium discoideum AX4 (strain: AX4)
Lineage
Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales; Dictyosteliaceae; Dictyostelium
Old locus tag
DDBDRAFT_0189579; DDBDRAFT_0191115; DDB_0189579; DDB_0191115
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Genomic context

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Location:
chromosome: 1
Exon count:
1
Sequence:
Chromosome: 1; NC_007087.3 (943374..944711, complement)

Chromosome 1 - NC_007087.3Genomic Context describing neighboring genes Neighboring gene hypothetical protein Neighboring gene hypothetical protein Neighboring gene hypothetical protein Neighboring gene tRNA-Ser Neighboring gene hypothetical protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_007087.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Coronin, an actin binding protein of Dictyostelium discoideum localized to cell surface projections, has sequence similarities to G protein beta subunits. de Hostos EL, et al. EMBO J, 1991 Dec. PMID 1661669, Free PMC Article
  2. Dictyostelium mutants lacking the cytoskeletal protein coronin are defective in cytokinesis and cell motility. de Hostos EL, et al. J Cell Biol, 1993 Jan. PMID 8380174, Free PMC Article
  3. Coronin involved in phagocytosis: dynamics of particle-induced relocalization visualized by a green fluorescent protein Tag. Maniak M, et al. Cell, 1995 Dec 15. PMID 8521515
  4. Architectural dynamics and gene replacement of coronin suggest its role in cytokinesis. Fukui Y, et al. Cell Motil Cytoskeleton, 1999. PMID 10098934
  5. Initiation of multicellular differentiation in Dictyostelium discoideum is regulated by coronin A. Vinet AF, et al. Mol Biol Cell, 2014 Mar. PMID 24403600, Free PMC Article

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Interactome and F-Actin Interaction Analysis of Dictyostelium discoideum Coronin A.
    Title: Interactome and F-Actin Interaction Analysis of Dictyostelium discoideum Coronin A.
  2. coronin through its affinity for GDP-Rac regulates the availability of GTP-Rac for activation of downstream effectors
    Title: A Cdc42- and Rac-interactive binding (CRIB) domain mediates functions of coronin.
  3. acts in actin disassembly in actin cytoskeleton
    Title: Redundant and unique roles of coronin proteins in Dictyostelium.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by dictyBase

Function Evidence Code Pubs
enables actin binding IEA
Inferred from Electronic Annotation
more info
  
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables actin filament binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within actin cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within actin filament depolymerization IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in actin filament organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in actin filament organization IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within aggregation involved in sorocarp development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cell motility IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within defense response to bacterium IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within endocytosis TAS
Traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within hyperosmotic response IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within intranuclear rod assembly IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within mitotic cleavage furrow formation IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within mitotic cytokinesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within mitotic cytokinesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within oscillatory cAMP signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in phagocytosis IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in phagocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of myosin II filament disassembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to bacterium HEP PubMed 
involved_in response to curcumin IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within response to other organism TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
is_active_in actin cytoskeleton IDA
Inferred from Direct Assay
more info
 PubMed 
located_in anterior cell cortex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell cortex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell pole IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell projection IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell surface IEA
Inferred from Electronic Annotation
more info
  
located_in cell tip IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cleavage furrow IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cortical cytoskeleton IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular matrix HDA PubMed 
located_in intranuclear rod IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitotic spindle polar microtubule IDA
Inferred from Direct Assay
more info
 PubMed 
located_in pathogen-containing vacuole HDA PubMed 
located_in pathogen-containing vacuole IDA
Inferred from Direct Assay
more info
 PubMed 
located_in phagocytic cup IDA
Inferred from Direct Assay
more info
 PubMed 
located_in phagocytic vesicle HDA PubMed 
is_active_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane bounded cell projection IDA
Inferred from Direct Assay
more info
 PubMed 
located_in posterior cell cortex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in vesicle IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
WD-40 repeat-containing protein
Names
actin binding protein

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_007087.3 Reference assembly

    Range
    943374..944711 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_642251.1 → XP_647343.1  actin binding protein [Dictyostelium discoideum AX4]

    See identical proteins and their annotated locations for XP_647343.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P27133, Q55G40
    Conserved Domains (4) summary
    pfam08953
    Location:6 → 63
    DUF1899; Domain of unknown function (DUF1899)
    pfam16300
    Location:339 → 381
    WD40_4; Type of WD40 repeat
    sd00039
    Location:83 → 127
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:77 → 296
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
Nucleotide Protein
Heading Accession and Version

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