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YRF1-2 Y' element ATP-dependent helicase protein 1 copy 2 [ Saccharomyces cerevisiae S288C ]

Gene ID: 856940, updated on 29-Jun-2024

Summary

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Gene symbol
YRF1-2
Gene description
Y' element ATP-dependent helicase protein 1 copy 2
Primary source
FungiDB:YER190W
Locus tag
YER190W
See related
SGD:S000000992; AllianceGenome:SGD:S000000992; VEuPathDB:YER190W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
YRF1
Summary
Enables DNA helicase activity. Involved in telomere maintenance via recombination. Predicted to be located in nucleus. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See YRF1-2 in Genome Data Viewer
Location:
chromosome: V
Exon count:
1
Sequence:
Chromosome: V; NC_001137.3 (571480..576525)

Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001137.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genome-wide array-CGH analysis reveals YRF1 gene copy number variation that modulates genetic stability in distillery yeasts. Deregowska A, et al. Oncotarget, 2015 Oct 13. PMID 26384347, Free PMC Article
  2. A genetic screen for yeast genes induced by sustained osmotic stress. Runner VM, et al. Yeast, 2003 Jul 30. PMID 12868060
  3. Specific transcriptional responses induced by 8-methoxypsoralen and UVA in yeast. Dardalhon M, et al. FEMS Yeast Res, 2007 Sep. PMID 17608707, Free PMC Article
  4. Y'-Help1, a DNA helicase encoded by the yeast subtelomeric Y' element, is induced in survivors defective for telomerase. Yamada M, et al. J Biol Chem, 1998 Dec 11. PMID 9837911
  5. The heme a synthase Cox15 associates with cytochrome c oxidase assembly intermediates during Cox1 maturation. Bareth B, et al. Mol Cell Biol, 2013 Oct. PMID 23979592, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA helicase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables helicase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA duplex unwinding IEA
Inferred from Electronic Annotation
more info
  
involved_in telomere maintenance via recombination IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IC
Inferred by Curator
more info
 PubMed 

General protein information

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Preferred Names
Y' element ATP-dependent helicase protein 1 copy 2
NP_011117.3
  • Helicase encoded by the Y' element of subtelomeric regions; highly expressed in the mutants lacking the telomerase component TLC1; potentially phosphorylated by Cdc28p; induced by treatment with 8-methoxypsoralen and UVA irradiation

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001137.3 Reference assembly

    Range
    571480..576525
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179080.3 → NP_011117.3  TPA: Y' element ATP-dependent helicase protein 1 copy 2 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011117.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D3DM99, P40105
    UniProtKB/TrEMBL
    A0A8H8UM54
    Conserved Domains (1) summary
    COG0513
    Location:622 → 1138
    SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P40105.2

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